Warming effect on miriplatin-lipiodol suspension for potential use as a chemotherapeutic agent for transarterial chemoembolization of hepatocellular carcinoma: In vitro study
Aim To elucidate whether warming may reduce the viscosity of miriplatin–lipiodol suspension (MPT/LPD) and also the injection pressure through microcatheters, for potential use as a chemotherapeutic agent of transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). Methods Viscosity...
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| Veröffentlicht in: | Hepatology research 2013-10, Vol.43 (10), p.1100-1104 |
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| container_title | Hepatology research |
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| creator | Kora, Shin-ichi Urakawa, Hiroshi Mitsufuji, Toshimichi Osame, Akinobu Higashihara, Hideyuki Ohki, Toshihiro Yoshimitsu, Kengo |
| description | Aim
To elucidate whether warming may reduce the viscosity of miriplatin–lipiodol suspension (MPT/LPD) and also the injection pressure through microcatheters, for potential use as a chemotherapeutic agent of transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).
Methods
Viscosity of MPT/LPD prepared at on‐label dose was measured in vitro at 25°C, 30°C, 40°C, 50°C and 60°C using capillary tube method. Reproducibility of viscosity change was also tested. Injection pressure through two different commercially available microcatheters was measured using a rheometer. Data sampling was performed at least twice for each measurement.
Results
Viscosity of MPT/LPD was significantly reduced as the temperature was elevated (R2 = 0.9586, P |
| doi_str_mv | 10.1111/hepr.12050 |
| format | Article |
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To elucidate whether warming may reduce the viscosity of miriplatin–lipiodol suspension (MPT/LPD) and also the injection pressure through microcatheters, for potential use as a chemotherapeutic agent of transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).
Methods
Viscosity of MPT/LPD prepared at on‐label dose was measured in vitro at 25°C, 30°C, 40°C, 50°C and 60°C using capillary tube method. Reproducibility of viscosity change was also tested. Injection pressure through two different commercially available microcatheters was measured using a rheometer. Data sampling was performed at least twice for each measurement.
Results
Viscosity of MPT/LPD was significantly reduced as the temperature was elevated (R2 = 0.9586, P < 0.0001, Pearson's correlation); at 40°C, it was almost half of that at room temperature (25°C). Repeated warming and cooling down of MPT/LPD revealed good reproducibility of viscosity change. Injection pressure through either microcatheter showed significant reduction when MPT/LPD was warmed (P < 0.05, Spearman's rank correlation coefficient).
Conclusion
The viscosity and injection pressure through microcatheters of MPT/LPD was confirmed to reduce significantly as the temperature is elevated. MPT/LPD warmed to 40°C has half viscosity as that at room temperature and is considered suitable for clinical use. Warming MPT/LPD may have potential to facilitate the procedure of TACE for HCC.</description><identifier>ISSN: 1386-6346</identifier><identifier>EISSN: 1872-034X</identifier><identifier>DOI: 10.1111/hepr.12050</identifier><identifier>PMID: 23347354</identifier><language>eng</language><publisher>Netherlands: Blackwell Publishing Ltd</publisher><subject>chemoembolization ; hepatocellular carcinoma ; miriplatin ; warming</subject><ispartof>Hepatology research, 2013-10, Vol.43 (10), p.1100-1104</ispartof><rights>2012 The Japan Society of Hepatology</rights><rights>2012 The Japan Society of Hepatology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4570-bbe5df3758b3ed2fd31f9e4c0051127bc8ce8d8bce9bf7a8236eaa42a3c8d9b93</citedby><cites>FETCH-LOGICAL-c4570-bbe5df3758b3ed2fd31f9e4c0051127bc8ce8d8bce9bf7a8236eaa42a3c8d9b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhepr.12050$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhepr.12050$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23347354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kora, Shin-ichi</creatorcontrib><creatorcontrib>Urakawa, Hiroshi</creatorcontrib><creatorcontrib>Mitsufuji, Toshimichi</creatorcontrib><creatorcontrib>Osame, Akinobu</creatorcontrib><creatorcontrib>Higashihara, Hideyuki</creatorcontrib><creatorcontrib>Ohki, Toshihiro</creatorcontrib><creatorcontrib>Yoshimitsu, Kengo</creatorcontrib><title>Warming effect on miriplatin-lipiodol suspension for potential use as a chemotherapeutic agent for transarterial chemoembolization of hepatocellular carcinoma: In vitro study</title><title>Hepatology research</title><addtitle>Hepatol Res</addtitle><description>Aim
To elucidate whether warming may reduce the viscosity of miriplatin–lipiodol suspension (MPT/LPD) and also the injection pressure through microcatheters, for potential use as a chemotherapeutic agent of transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).
Methods
Viscosity of MPT/LPD prepared at on‐label dose was measured in vitro at 25°C, 30°C, 40°C, 50°C and 60°C using capillary tube method. Reproducibility of viscosity change was also tested. Injection pressure through two different commercially available microcatheters was measured using a rheometer. Data sampling was performed at least twice for each measurement.
Results
Viscosity of MPT/LPD was significantly reduced as the temperature was elevated (R2 = 0.9586, P < 0.0001, Pearson's correlation); at 40°C, it was almost half of that at room temperature (25°C). Repeated warming and cooling down of MPT/LPD revealed good reproducibility of viscosity change. Injection pressure through either microcatheter showed significant reduction when MPT/LPD was warmed (P < 0.05, Spearman's rank correlation coefficient).
Conclusion
The viscosity and injection pressure through microcatheters of MPT/LPD was confirmed to reduce significantly as the temperature is elevated. MPT/LPD warmed to 40°C has half viscosity as that at room temperature and is considered suitable for clinical use. Warming MPT/LPD may have potential to facilitate the procedure of TACE for HCC.</description><subject>chemoembolization</subject><subject>hepatocellular carcinoma</subject><subject>miriplatin</subject><subject>warming</subject><issn>1386-6346</issn><issn>1872-034X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kd1u1DAQhSMEoj9wwwMgXyKktHbsJF7uoOqfVNEKgRZxY02ccdfgxMF2gOWheMZ6d9teYlmypfnOGY9PUbxi9IjldbzCKRyxitb0SbHPZFuVlIuvT_Ody6ZsuGj2ioMYv1PKWlqJ58VexbloeS32i39LCIMdbwkagzoRP5LBBjs5SHYsnZ2s770jcY4TjtHmsvGBTD7hmCw4MkckEAkQvcLBpxUGmHBOVhO4zciWTgHGCCFh2Ci2IA6dd_ZvbpIdvSF5BEheo3Ozg0A0BG1HP8A7cjmSXzYFT2Ka-_WL4pkBF_Hl_XlYfDk7_XxyUV5dn1-evL8qtahbWnYd1r3hbS07jn1les7MAoWmtGasajstNcpedhoXnWlBVrxBAFEB17JfdAt-WLzZ-U7B_5wxJjXYuHkejOjnqJgQnMu8ZUbf7lAdfIwBjZqCHSCsFaNqk4_a5KO2-WT49b3v3A3YP6IPgWSA7YDf1uH6P1bq4vTm04NpudPYmPDPowbCD9W0-RPU8uO5-kCXnH_jjar5HaxYsJQ</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Kora, Shin-ichi</creator><creator>Urakawa, Hiroshi</creator><creator>Mitsufuji, Toshimichi</creator><creator>Osame, Akinobu</creator><creator>Higashihara, Hideyuki</creator><creator>Ohki, Toshihiro</creator><creator>Yoshimitsu, Kengo</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201310</creationdate><title>Warming effect on miriplatin-lipiodol suspension for potential use as a chemotherapeutic agent for transarterial chemoembolization of hepatocellular carcinoma: In vitro study</title><author>Kora, Shin-ichi ; Urakawa, Hiroshi ; Mitsufuji, Toshimichi ; Osame, Akinobu ; Higashihara, Hideyuki ; Ohki, Toshihiro ; Yoshimitsu, Kengo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4570-bbe5df3758b3ed2fd31f9e4c0051127bc8ce8d8bce9bf7a8236eaa42a3c8d9b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>chemoembolization</topic><topic>hepatocellular carcinoma</topic><topic>miriplatin</topic><topic>warming</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kora, Shin-ichi</creatorcontrib><creatorcontrib>Urakawa, Hiroshi</creatorcontrib><creatorcontrib>Mitsufuji, Toshimichi</creatorcontrib><creatorcontrib>Osame, Akinobu</creatorcontrib><creatorcontrib>Higashihara, Hideyuki</creatorcontrib><creatorcontrib>Ohki, Toshihiro</creatorcontrib><creatorcontrib>Yoshimitsu, Kengo</creatorcontrib><collection>Istex</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kora, Shin-ichi</au><au>Urakawa, Hiroshi</au><au>Mitsufuji, Toshimichi</au><au>Osame, Akinobu</au><au>Higashihara, Hideyuki</au><au>Ohki, Toshihiro</au><au>Yoshimitsu, Kengo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Warming effect on miriplatin-lipiodol suspension for potential use as a chemotherapeutic agent for transarterial chemoembolization of hepatocellular carcinoma: In vitro study</atitle><jtitle>Hepatology research</jtitle><addtitle>Hepatol Res</addtitle><date>2013-10</date><risdate>2013</risdate><volume>43</volume><issue>10</issue><spage>1100</spage><epage>1104</epage><pages>1100-1104</pages><issn>1386-6346</issn><eissn>1872-034X</eissn><abstract>Aim
To elucidate whether warming may reduce the viscosity of miriplatin–lipiodol suspension (MPT/LPD) and also the injection pressure through microcatheters, for potential use as a chemotherapeutic agent of transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).
Methods
Viscosity of MPT/LPD prepared at on‐label dose was measured in vitro at 25°C, 30°C, 40°C, 50°C and 60°C using capillary tube method. Reproducibility of viscosity change was also tested. Injection pressure through two different commercially available microcatheters was measured using a rheometer. Data sampling was performed at least twice for each measurement.
Results
Viscosity of MPT/LPD was significantly reduced as the temperature was elevated (R2 = 0.9586, P < 0.0001, Pearson's correlation); at 40°C, it was almost half of that at room temperature (25°C). Repeated warming and cooling down of MPT/LPD revealed good reproducibility of viscosity change. Injection pressure through either microcatheter showed significant reduction when MPT/LPD was warmed (P < 0.05, Spearman's rank correlation coefficient).
Conclusion
The viscosity and injection pressure through microcatheters of MPT/LPD was confirmed to reduce significantly as the temperature is elevated. MPT/LPD warmed to 40°C has half viscosity as that at room temperature and is considered suitable for clinical use. Warming MPT/LPD may have potential to facilitate the procedure of TACE for HCC.</abstract><cop>Netherlands</cop><pub>Blackwell Publishing Ltd</pub><pmid>23347354</pmid><doi>10.1111/hepr.12050</doi><tpages>5</tpages></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | chemoembolization hepatocellular carcinoma miriplatin warming |
| title | Warming effect on miriplatin-lipiodol suspension for potential use as a chemotherapeutic agent for transarterial chemoembolization of hepatocellular carcinoma: In vitro study |
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