Association between human papillomavirus infection and cytological abnormalities during early follow-up of invasive cervical cancer
Considering the limitations of cytology for detection of residual cervical cancer after radiotherapy, the aim of this study was to evaluate the frequency and viral load of high‐risk HPV in cervical and vaginal samples during the early follow‐up of patients treated for invasive cervical cancer and co...
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| Veröffentlicht in: | Journal of medical virology 2012-07, Vol.84 (7), p.1115-1119 |
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| creator | de Azevedo, Ana Emília Borges Carneiro, Fabiana Pirani Neto, Florêncio Figueiredo Cavalcante Bocca, Anamélia Lorenzetti Teixeira, Lorenna Sena de Queiroz Maurício Filho, Marco Antônio Freitas de Padua Nakashima, Juliano de Abreu, Wenzel Castro Muniz-Junqueira, Maria Imaculada de Magalhães, Albino Verçosa |
| description | Considering the limitations of cytology for detection of residual cervical cancer after radiotherapy, the aim of this study was to evaluate the frequency and viral load of high‐risk HPV in cervical and vaginal samples during the early follow‐up of patients treated for invasive cervical cancer and correlate the results with cytological examination. Conventional cytology and hybrid capture test were performed on cervical and vaginal samples of 52 women with invasive cervical carcinoma 3 months after therapy. High‐risk HPV was detected in 46.1% of the samples and the median and the range of the ratio relative light unit (RLU)/cutoff (CO) (estimated viral load) in positive samples was 1.71 (1–2120.03). No significant difference was observed in viral frequency and in median of the ratio RLU/CO between samples of patients at different stages (I–III) and between cervical samples, from patients treated by exclusive radiotherapy with or without chemotherapy, and vaginal samples, from patients who underwent to hysterectomy and radiotherapy with or without chemotherapy. Cytological abnormalities were more frequent significantly in samples with HPV than in samples without HPV. The viral load was also higher significantly in samples with cytological abnormalities when compared with the samples without cytological abnormalities. In conclusion, HPV detection methods may be useful during the early follow‐up as a complement to conventional cytology for the diagnosis of residual cervical cancer after radiotherapy. J. Med. Virol. 84: 1115–1119, 2012. © 2012 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmv.23303 |
| format | Article |
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Conventional cytology and hybrid capture test were performed on cervical and vaginal samples of 52 women with invasive cervical carcinoma 3 months after therapy. High‐risk HPV was detected in 46.1% of the samples and the median and the range of the ratio relative light unit (RLU)/cutoff (CO) (estimated viral load) in positive samples was 1.71 (1–2120.03). No significant difference was observed in viral frequency and in median of the ratio RLU/CO between samples of patients at different stages (I–III) and between cervical samples, from patients treated by exclusive radiotherapy with or without chemotherapy, and vaginal samples, from patients who underwent to hysterectomy and radiotherapy with or without chemotherapy. Cytological abnormalities were more frequent significantly in samples with HPV than in samples without HPV. The viral load was also higher significantly in samples with cytological abnormalities when compared with the samples without cytological abnormalities. In conclusion, HPV detection methods may be useful during the early follow‐up as a complement to conventional cytology for the diagnosis of residual cervical cancer after radiotherapy. J. Med. Virol. 84: 1115–1119, 2012. © 2012 Wiley Periodicals, Inc.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.23303</identifier><identifier>PMID: 22585730</identifier><identifier>CODEN: JMVIDB</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; Carcinoma - pathology ; Carcinoma - therapy ; Carcinoma - virology ; Cellular biology ; Cervical cancer ; cervical cytology ; Cervix Uteri - cytology ; Cervix Uteri - virology ; Cytological Techniques ; Drug Therapy - methods ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Genotype ; HPV ; Human papillomavirus ; Human viral diseases ; Humans ; hybrid capture ; Infectious diseases ; Medical diagnosis ; Medical sciences ; Microbiology ; Miscellaneous ; Papillomaviridae - classification ; Papillomaviridae - isolation & purification ; Papillomavirus Infections - complications ; Papillomavirus Infections - pathology ; Papillomavirus Infections - therapy ; radiotherapy ; Radiotherapy - methods ; Treatment Outcome ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - therapy ; Uterine Cervical Neoplasms - virology ; Vagina - cytology ; Vagina - virology ; Vaginal Smears ; Viral diseases ; Viral Load ; Virology ; Virology - methods</subject><ispartof>Journal of medical virology, 2012-07, Vol.84 (7), p.1115-1119</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4543-52827147d3b89d20250267412c08db57e92e75e3e157def99932726ece0551b23</citedby><cites>FETCH-LOGICAL-c4543-52827147d3b89d20250267412c08db57e92e75e3e157def99932726ece0551b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.23303$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.23303$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45552,45553</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25913197$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22585730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Azevedo, Ana Emília Borges</creatorcontrib><creatorcontrib>Carneiro, Fabiana Pirani</creatorcontrib><creatorcontrib>Neto, Florêncio Figueiredo Cavalcante</creatorcontrib><creatorcontrib>Bocca, Anamélia Lorenzetti</creatorcontrib><creatorcontrib>Teixeira, Lorenna Sena</creatorcontrib><creatorcontrib>de Queiroz Maurício Filho, Marco Antônio Freitas</creatorcontrib><creatorcontrib>de Padua Nakashima, Juliano</creatorcontrib><creatorcontrib>de Abreu, Wenzel Castro</creatorcontrib><creatorcontrib>Muniz-Junqueira, Maria Imaculada</creatorcontrib><creatorcontrib>de Magalhães, Albino Verçosa</creatorcontrib><title>Association between human papillomavirus infection and cytological abnormalities during early follow-up of invasive cervical cancer</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>Considering the limitations of cytology for detection of residual cervical cancer after radiotherapy, the aim of this study was to evaluate the frequency and viral load of high‐risk HPV in cervical and vaginal samples during the early follow‐up of patients treated for invasive cervical cancer and correlate the results with cytological examination. Conventional cytology and hybrid capture test were performed on cervical and vaginal samples of 52 women with invasive cervical carcinoma 3 months after therapy. High‐risk HPV was detected in 46.1% of the samples and the median and the range of the ratio relative light unit (RLU)/cutoff (CO) (estimated viral load) in positive samples was 1.71 (1–2120.03). No significant difference was observed in viral frequency and in median of the ratio RLU/CO between samples of patients at different stages (I–III) and between cervical samples, from patients treated by exclusive radiotherapy with or without chemotherapy, and vaginal samples, from patients who underwent to hysterectomy and radiotherapy with or without chemotherapy. Cytological abnormalities were more frequent significantly in samples with HPV than in samples without HPV. The viral load was also higher significantly in samples with cytological abnormalities when compared with the samples without cytological abnormalities. In conclusion, HPV detection methods may be useful during the early follow‐up as a complement to conventional cytology for the diagnosis of residual cervical cancer after radiotherapy. J. Med. Virol. 84: 1115–1119, 2012. © 2012 Wiley Periodicals, Inc.</description><subject>Biological and medical sciences</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - therapy</subject><subject>Carcinoma - virology</subject><subject>Cellular biology</subject><subject>Cervical cancer</subject><subject>cervical cytology</subject><subject>Cervix Uteri - cytology</subject><subject>Cervix Uteri - virology</subject><subject>Cytological Techniques</subject><subject>Drug Therapy - methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotype</subject><subject>HPV</subject><subject>Human papillomavirus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>hybrid capture</subject><subject>Infectious diseases</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Papillomaviridae - classification</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - pathology</subject><subject>Papillomavirus Infections - therapy</subject><subject>radiotherapy</subject><subject>Radiotherapy - methods</subject><subject>Treatment Outcome</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - therapy</subject><subject>Uterine Cervical Neoplasms - virology</subject><subject>Vagina - cytology</subject><subject>Vagina - virology</subject><subject>Vaginal Smears</subject><subject>Viral diseases</subject><subject>Viral Load</subject><subject>Virology</subject><subject>Virology - methods</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P0zAQhi0EYkvhwB9AlhASHLLrzzg-7hYoHwtc-DhajjNZXJK42ElLz_xxTNtdJCTEaXx45hnPvAg9pOSUEsLOVv3mlHFO-C00o0SXhSaK3kYzQkVZlCWVJ-heSitCSKUZu4tOGJOVVJzM0M_zlILzdvRhwDWMW4ABf516O-C1XfuuC73d-Dgl7IcW3B6zQ4PdbgxduPLOdtjWQ4i97fzoIeFmin64wmBjt8NtyIZtMa1xaLNhY5PfAHYQN_tOZ4f8vo_utLZL8OBY5-jTyxcfF6-Kyw_L14vzy8IJKXghWcUUFarhdaUbRpgkrFSCMkeqppYKNAMlgQOVqoFWa82ZYiU4IFLSmvE5enrwrmP4PkEaTe-Tg66zA4QpGSoE50ppQf-PEsp1_gIjGX38F7oKUxzyIlnIK6pEmescPTtQLoaUIrRmHX1v4y6rzO8QTQ7R7EPM7KOjcap7aG7I69Qy8OQI2JTP2MZ8Rp_-cFJTTrXK3NmB2_oOdv-eaN68-3w9ujh0-DTCj5sOG7-ZUnElzZf3SyMWz8XbJb0wgv8C-wnCKg</recordid><startdate>201207</startdate><enddate>201207</enddate><creator>de Azevedo, Ana Emília Borges</creator><creator>Carneiro, Fabiana Pirani</creator><creator>Neto, Florêncio Figueiredo Cavalcante</creator><creator>Bocca, Anamélia Lorenzetti</creator><creator>Teixeira, Lorenna Sena</creator><creator>de Queiroz Maurício Filho, Marco Antônio Freitas</creator><creator>de Padua Nakashima, Juliano</creator><creator>de Abreu, Wenzel Castro</creator><creator>Muniz-Junqueira, Maria Imaculada</creator><creator>de Magalhães, Albino Verçosa</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201207</creationdate><title>Association between human papillomavirus infection and cytological abnormalities during early follow-up of invasive cervical cancer</title><author>de Azevedo, Ana Emília Borges ; Carneiro, Fabiana Pirani ; Neto, Florêncio Figueiredo Cavalcante ; Bocca, Anamélia Lorenzetti ; Teixeira, Lorenna Sena ; de Queiroz Maurício Filho, Marco Antônio Freitas ; de Padua Nakashima, Juliano ; de Abreu, Wenzel Castro ; Muniz-Junqueira, Maria Imaculada ; de Magalhães, Albino Verçosa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4543-52827147d3b89d20250267412c08db57e92e75e3e157def99932726ece0551b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biological and medical sciences</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - therapy</topic><topic>Carcinoma - virology</topic><topic>Cellular biology</topic><topic>Cervical cancer</topic><topic>cervical cytology</topic><topic>Cervix Uteri - cytology</topic><topic>Cervix Uteri - virology</topic><topic>Cytological Techniques</topic><topic>Drug Therapy - methods</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotype</topic><topic>HPV</topic><topic>Human papillomavirus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>hybrid capture</topic><topic>Infectious diseases</topic><topic>Medical diagnosis</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Papillomaviridae - classification</topic><topic>Papillomaviridae - isolation & purification</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - pathology</topic><topic>Papillomavirus Infections - therapy</topic><topic>radiotherapy</topic><topic>Radiotherapy - methods</topic><topic>Treatment Outcome</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - therapy</topic><topic>Uterine Cervical Neoplasms - virology</topic><topic>Vagina - cytology</topic><topic>Vagina - virology</topic><topic>Vaginal Smears</topic><topic>Viral diseases</topic><topic>Viral Load</topic><topic>Virology</topic><topic>Virology - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Azevedo, Ana Emília Borges</creatorcontrib><creatorcontrib>Carneiro, Fabiana Pirani</creatorcontrib><creatorcontrib>Neto, Florêncio Figueiredo Cavalcante</creatorcontrib><creatorcontrib>Bocca, Anamélia Lorenzetti</creatorcontrib><creatorcontrib>Teixeira, Lorenna Sena</creatorcontrib><creatorcontrib>de Queiroz Maurício Filho, Marco Antônio Freitas</creatorcontrib><creatorcontrib>de Padua Nakashima, Juliano</creatorcontrib><creatorcontrib>de Abreu, Wenzel Castro</creatorcontrib><creatorcontrib>Muniz-Junqueira, Maria Imaculada</creatorcontrib><creatorcontrib>de Magalhães, Albino Verçosa</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Azevedo, Ana Emília Borges</au><au>Carneiro, Fabiana Pirani</au><au>Neto, Florêncio Figueiredo Cavalcante</au><au>Bocca, Anamélia Lorenzetti</au><au>Teixeira, Lorenna Sena</au><au>de Queiroz Maurício Filho, Marco Antônio Freitas</au><au>de Padua Nakashima, Juliano</au><au>de Abreu, Wenzel Castro</au><au>Muniz-Junqueira, Maria Imaculada</au><au>de Magalhães, Albino Verçosa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between human papillomavirus infection and cytological abnormalities during early follow-up of invasive cervical cancer</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. 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No significant difference was observed in viral frequency and in median of the ratio RLU/CO between samples of patients at different stages (I–III) and between cervical samples, from patients treated by exclusive radiotherapy with or without chemotherapy, and vaginal samples, from patients who underwent to hysterectomy and radiotherapy with or without chemotherapy. Cytological abnormalities were more frequent significantly in samples with HPV than in samples without HPV. The viral load was also higher significantly in samples with cytological abnormalities when compared with the samples without cytological abnormalities. In conclusion, HPV detection methods may be useful during the early follow‐up as a complement to conventional cytology for the diagnosis of residual cervical cancer after radiotherapy. J. Med. Virol. 84: 1115–1119, 2012. © 2012 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22585730</pmid><doi>10.1002/jmv.23303</doi><tpages>5</tpages></addata></record> |
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| subjects | Biological and medical sciences Carcinoma - pathology Carcinoma - therapy Carcinoma - virology Cellular biology Cervical cancer cervical cytology Cervix Uteri - cytology Cervix Uteri - virology Cytological Techniques Drug Therapy - methods Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Genotype HPV Human papillomavirus Human viral diseases Humans hybrid capture Infectious diseases Medical diagnosis Medical sciences Microbiology Miscellaneous Papillomaviridae - classification Papillomaviridae - isolation & purification Papillomavirus Infections - complications Papillomavirus Infections - pathology Papillomavirus Infections - therapy radiotherapy Radiotherapy - methods Treatment Outcome Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - therapy Uterine Cervical Neoplasms - virology Vagina - cytology Vagina - virology Vaginal Smears Viral diseases Viral Load Virology Virology - methods |
| title | Association between human papillomavirus infection and cytological abnormalities during early follow-up of invasive cervical cancer |
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