Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C‐C motif) ligand 5 (Ccl5)

ABSTRACT Chemokines play crucial roles in the recruitment of specific hematopoietic cell types, and some of them have been suggested to be involved in the regulation of bone remodeling. Because we have previously observed that chemokine (C‐C motif) ligand 2 (Ccl2) and Ccl5 are direct target genes of...

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Veröffentlicht in:	Journal of bone and mineral research 2013-10, Vol.28 (10), p.2070-2080
Hauptverfasser:	Wintges, Kristofer, Beil, F Timo, Albers, Joachim, Jeschke, Anke, Schweizer, Michaela, Claass, Benjamin, Tiegs, Gisa, Amling, Michael, Schinke, Thorsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - metabolism Bone Marrow Cells - pathology Bone Remodeling CCL5 Cell Differentiation Cell Separation Cells, Cultured Chemokine CCL2 - deficiency Chemokine CCL2 - metabolism Chemokine CCL5 - deficiency Chemokine CCL5 - metabolism CHEMOKINES Culture Media, Conditioned - pharmacology Hematopoiesis Interleukin-18 - pharmacology Macrophages - metabolism Mice Mice, Inbred C57BL OSTEAL MACROPHAGES Osteoclasts - metabolism Osteogenesis OSTEOIMMUNOLOGY Spine - metabolism Spine - pathology Stem Cells - metabolism Tibia - metabolism Tibia - pathology
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