Validation of the German version of the extended ALS functional rating scale as a patient-reported outcome measure
The revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) is a well-established rating instrument to assess the functional status of ALS patients. A recent innovation was the addition of three further items designed to improve its sensitivity at lower levels of physical function (...
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| Veröffentlicht in: | Journal of neurology 2013-09, Vol.260 (9), p.2242-2255 |
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| creator | Abdulla, Susanne Vielhaber, Stefan Körner, Sonja Machts, Judith Heinze, Hans-Jochen Dengler, Reinhard Petri, Susanne |
| description | The revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) is a well-established rating instrument to assess the functional status of ALS patients. A recent innovation was the addition of three further items designed to improve its sensitivity at lower levels of physical function (ALSFRS-Extension, ALSFRS-EX). Neither the ALSFRS-R nor the ALSFRS-EX has been validated in German yet. The aim of the present study was the validation of the German version of a self-administered form of the ALSFRS-EX. Seventy-six patients participated in the study. Psychometric analysis included reliability assessment and factorial analysis. To evaluate convergent validity, correlations between ALSFRS-EX items and the MRC score, spasticity, tongue movement, pulmonary function, ALSAQ-40 and Borg dyspnoea scales (upright and supine) were performed. Internal consistency as measured by Cronbach’s alpha (total scale 0.868, subscales 0.690–0.938) and corrected item to total correlations (all above 0.50) was high. Test–retest reliability assessed by Spearman’s rho (0.882–0.972) and Cohen’s Kappa (0.63–0.92) was also high. Principal component analysis with varimax rotation yielded a four-factor solution accounting for approximately 79 % of the variance. Clinical parameters were strongly correlated with respective items and subscores of the ALSFRS-EX (muscle strength 0.568–0.833
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| doi_str_mv | 10.1007/s00415-013-6955-6 |
| format | Article |
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p
< 0.01; spasticity −0.236 to −0.376
p
< 0.05; tongue movement 0.437–0.818
p
< 0.01; pulmonary function 0.485–0.577
p
< 0.01). ALSAQ-40 and Borg score correlated highly with the corresponding ALSFRS-EX items. The German self-report version of the ALSFRS-EX possesses very good psychometric properties similar to the original scale including high internal consistency and test–retest reliability as well as excellent convergent validity.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-013-6955-6</identifier><identifier>PMID: 23736973</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Activities of Daily Living ; Adult ; Aged ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - complications ; Clinical outcomes ; Disease ; Female ; Humans ; Language ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurology ; Neuroradiology ; Neurosciences ; Original Communication ; Outcome and Process Assessment (Health Care) - methods ; Patients ; Quantitative psychology ; Reproducibility of Results ; Self Report ; Severity of Illness Index ; Spasticity ; Validity ; Young Adult</subject><ispartof>Journal of neurology, 2013-09, Vol.260 (9), p.2242-2255</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-545b6f2f4fda003ed824febcca4f9d85427394eb9c448e3f5a07ea62c9cde86f3</citedby><cites>FETCH-LOGICAL-c405t-545b6f2f4fda003ed824febcca4f9d85427394eb9c448e3f5a07ea62c9cde86f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-013-6955-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-013-6955-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23736973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdulla, Susanne</creatorcontrib><creatorcontrib>Vielhaber, Stefan</creatorcontrib><creatorcontrib>Körner, Sonja</creatorcontrib><creatorcontrib>Machts, Judith</creatorcontrib><creatorcontrib>Heinze, Hans-Jochen</creatorcontrib><creatorcontrib>Dengler, Reinhard</creatorcontrib><creatorcontrib>Petri, Susanne</creatorcontrib><title>Validation of the German version of the extended ALS functional rating scale as a patient-reported outcome measure</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>The revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) is a well-established rating instrument to assess the functional status of ALS patients. A recent innovation was the addition of three further items designed to improve its sensitivity at lower levels of physical function (ALSFRS-Extension, ALSFRS-EX). Neither the ALSFRS-R nor the ALSFRS-EX has been validated in German yet. The aim of the present study was the validation of the German version of a self-administered form of the ALSFRS-EX. Seventy-six patients participated in the study. Psychometric analysis included reliability assessment and factorial analysis. To evaluate convergent validity, correlations between ALSFRS-EX items and the MRC score, spasticity, tongue movement, pulmonary function, ALSAQ-40 and Borg dyspnoea scales (upright and supine) were performed. Internal consistency as measured by Cronbach’s alpha (total scale 0.868, subscales 0.690–0.938) and corrected item to total correlations (all above 0.50) was high. Test–retest reliability assessed by Spearman’s rho (0.882–0.972) and Cohen’s Kappa (0.63–0.92) was also high. Principal component analysis with varimax rotation yielded a four-factor solution accounting for approximately 79 % of the variance. Clinical parameters were strongly correlated with respective items and subscores of the ALSFRS-EX (muscle strength 0.568–0.833
p
< 0.01; spasticity −0.236 to −0.376
p
< 0.05; tongue movement 0.437–0.818
p
< 0.01; pulmonary function 0.485–0.577
p
< 0.01). ALSAQ-40 and Borg score correlated highly with the corresponding ALSFRS-EX items. The German self-report version of the ALSFRS-EX possesses very good psychometric properties similar to the original scale including high internal consistency and test–retest reliability as well as excellent convergent validity.</description><subject>Activities of Daily Living</subject><subject>Adult</subject><subject>Aged</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - complications</subject><subject>Clinical outcomes</subject><subject>Disease</subject><subject>Female</subject><subject>Humans</subject><subject>Language</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Communication</subject><subject>Outcome and Process Assessment (Health Care) - methods</subject><subject>Patients</subject><subject>Quantitative psychology</subject><subject>Reproducibility of Results</subject><subject>Self Report</subject><subject>Severity of Illness Index</subject><subject>Spasticity</subject><subject>Validity</subject><subject>Young Adult</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkcFqFTEUhoNY7LX6AG4k4MZN7MnkJDNZlqJVuOCi6jbkZk7qLTOTazIj-vZmvFWKIHQVOOf7_8D5GHsh4Y0EaM8LAEotQCphrNbCPGIbiaoRErV9zDagEIRWGk_Z01JuAaCriyfstFGtMrZVG5a_-GHf-3mfJp4in78Sv6I8-ol_p1zuTenHTFNPPb_YXvO4TGGN-IHnmp1ueAl-IO4L9_xQJzTNItMh5bkm0jKHNBIfyZcl0zN2Ev1Q6Pnde8Y-v3v76fK92H68-nB5sRUBQc9Co96Z2ESMvQdQ1HcNRtqF4DHavtPYtMoi7WxA7EhF7aElb5pgQ0-dieqMvT72HnL6tlCZ3bgvgYbBT5SW4iSiUi1aYx-AqvV0xq7oq3_Q27TkeonflALTKgmVkkcq5FRKpugOeT_6_NNJcKs7d3Tnqju3unOmZl7eNS-7kfq_iT-yKtAcgVJX0w3le1__t_UX5JOkuA</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Abdulla, Susanne</creator><creator>Vielhaber, Stefan</creator><creator>Körner, Sonja</creator><creator>Machts, Judith</creator><creator>Heinze, Hans-Jochen</creator><creator>Dengler, Reinhard</creator><creator>Petri, Susanne</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130901</creationdate><title>Validation of the German version of the extended ALS functional rating scale as a patient-reported outcome measure</title><author>Abdulla, Susanne ; 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A recent innovation was the addition of three further items designed to improve its sensitivity at lower levels of physical function (ALSFRS-Extension, ALSFRS-EX). Neither the ALSFRS-R nor the ALSFRS-EX has been validated in German yet. The aim of the present study was the validation of the German version of a self-administered form of the ALSFRS-EX. Seventy-six patients participated in the study. Psychometric analysis included reliability assessment and factorial analysis. To evaluate convergent validity, correlations between ALSFRS-EX items and the MRC score, spasticity, tongue movement, pulmonary function, ALSAQ-40 and Borg dyspnoea scales (upright and supine) were performed. Internal consistency as measured by Cronbach’s alpha (total scale 0.868, subscales 0.690–0.938) and corrected item to total correlations (all above 0.50) was high. Test–retest reliability assessed by Spearman’s rho (0.882–0.972) and Cohen’s Kappa (0.63–0.92) was also high. Principal component analysis with varimax rotation yielded a four-factor solution accounting for approximately 79 % of the variance. Clinical parameters were strongly correlated with respective items and subscores of the ALSFRS-EX (muscle strength 0.568–0.833
p
< 0.01; spasticity −0.236 to −0.376
p
< 0.05; tongue movement 0.437–0.818
p
< 0.01; pulmonary function 0.485–0.577
p
< 0.01). ALSAQ-40 and Borg score correlated highly with the corresponding ALSFRS-EX items. The German self-report version of the ALSFRS-EX possesses very good psychometric properties similar to the original scale including high internal consistency and test–retest reliability as well as excellent convergent validity.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23736973</pmid><doi>10.1007/s00415-013-6955-6</doi><tpages>14</tpages></addata></record> |
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| subjects | Activities of Daily Living Adult Aged Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - complications Clinical outcomes Disease Female Humans Language Male Medicine Medicine & Public Health Middle Aged Neurology Neuroradiology Neurosciences Original Communication Outcome and Process Assessment (Health Care) - methods Patients Quantitative psychology Reproducibility of Results Self Report Severity of Illness Index Spasticity Validity Young Adult |
| title | Validation of the German version of the extended ALS functional rating scale as a patient-reported outcome measure |
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