Association of Endothelin-converting Enzyme-1b C-338A Polymorphism with Increased Risk of Ischemic Stroke in Chinese Han Population
Endothelin-converting enzyme-1b (ECE-1b) C-338A is a polymorphism located in ECE-1 gene promoter, which has been reported to correlate with the risk of carotid atherosclerosis. We conducted a hospital-based case–control study of 309 patients with ischemic stroke and 309 controls matched on age and g...
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| Veröffentlicht in: | Journal of molecular neuroscience 2013-10, Vol.51 (2), p.485-492 |
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| creator | Li, Rui Cui, Min Zhao, Jin Yu, Mingming Ying, Zegang Zhou, Shiming Zhou, Huadong |
| description | Endothelin-converting enzyme-1b (ECE-1b) C-338A is a polymorphism located in ECE-1 gene promoter, which has been reported to correlate with the risk of carotid atherosclerosis. We conducted a hospital-based case–control study of 309 patients with ischemic stroke and 309 controls matched on age and gender. The frequencies of ECE-1b-338 CC, CA, and AA genotypes in cases (45.0, 40.4, and 14.6 %) were significantly different from those of controls (53.1, 39.1, and 7.8 %,
χ
2
= 8.519,
P
= 0.014), respectively. Compared with C carriers, A alleles showed correlation with a 42 % increased risk of ischemic stroke (adjusted odds ratio (OR) = 1.42, 95 % CI = 1.11–1.81). After adjustment for potential risk factors, the AA genotype still kept positive correlation with ischemic stroke (OR = 1.78; 95 % CI = 1.06–3.54). In stratified analyses, the significant association of the A allele with ischemic stroke was observed in female subjects (adjusted OR = 1.64, 95 % CI = 1.17–2.89) and the subjects with age ≥64 years old (adjusted OR = 2.09, 95 % CI = 1.38–3.23). The present study suggested that the C-338A polymorphism of the ECE-1b gene was associated with an increased risk of ischemic stroke in the Chinese Han population. |
| doi_str_mv | 10.1007/s12031-013-0100-y |
| format | Article |
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χ
2
= 8.519,
P
= 0.014), respectively. Compared with C carriers, A alleles showed correlation with a 42 % increased risk of ischemic stroke (adjusted odds ratio (OR) = 1.42, 95 % CI = 1.11–1.81). After adjustment for potential risk factors, the AA genotype still kept positive correlation with ischemic stroke (OR = 1.78; 95 % CI = 1.06–3.54). In stratified analyses, the significant association of the A allele with ischemic stroke was observed in female subjects (adjusted OR = 1.64, 95 % CI = 1.17–2.89) and the subjects with age ≥64 years old (adjusted OR = 2.09, 95 % CI = 1.38–3.23). The present study suggested that the C-338A polymorphism of the ECE-1b gene was associated with an increased risk of ischemic stroke in the Chinese Han population.</description><identifier>ISSN: 0895-8696</identifier><identifier>EISSN: 1559-1166</identifier><identifier>DOI: 10.1007/s12031-013-0100-y</identifier><identifier>PMID: 24026618</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Age Factors ; Aged ; Alleles ; Antihypertensives ; Aspartic Acid Endopeptidases - genetics ; Atherosclerosis ; Biomedical and Life Sciences ; Biomedicine ; Blood pressure ; Brain Ischemia - diagnosis ; Brain Ischemia - genetics ; Cardiovascular disease ; Case-Control Studies ; Cell Biology ; China ; Cholesterol ; Diabetes ; Endothelin-Converting Enzymes ; Enzymes ; Female ; Genetic Predisposition to Disease ; Glucose ; Heterozygote ; High density lipoprotein ; Hospitals ; Humans ; Hypertension ; Ischemia ; Magnetic resonance imaging ; Male ; Metalloendopeptidases - genetics ; Middle Aged ; Neurochemistry ; Neurology ; Neurosciences ; Polymorphism ; Polymorphism, Single Nucleotide ; Proteomics ; Risk factors ; Sex Factors ; Smoking ; Smooth muscle ; Stroke ; Stroke - diagnosis ; Stroke - genetics</subject><ispartof>Journal of molecular neuroscience, 2013-10, Vol.51 (2), p.485-492</ispartof><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-ad672c68fd7148268fbe1f2f42d5533e41250813fe0934ee88a23cfb298c3ab3</citedby><cites>FETCH-LOGICAL-c405t-ad672c68fd7148268fbe1f2f42d5533e41250813fe0934ee88a23cfb298c3ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12031-013-0100-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12031-013-0100-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24026618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Rui</creatorcontrib><creatorcontrib>Cui, Min</creatorcontrib><creatorcontrib>Zhao, Jin</creatorcontrib><creatorcontrib>Yu, Mingming</creatorcontrib><creatorcontrib>Ying, Zegang</creatorcontrib><creatorcontrib>Zhou, Shiming</creatorcontrib><creatorcontrib>Zhou, Huadong</creatorcontrib><title>Association of Endothelin-converting Enzyme-1b C-338A Polymorphism with Increased Risk of Ischemic Stroke in Chinese Han Population</title><title>Journal of molecular neuroscience</title><addtitle>J Mol Neurosci</addtitle><addtitle>J Mol Neurosci</addtitle><description>Endothelin-converting enzyme-1b (ECE-1b) C-338A is a polymorphism located in ECE-1 gene promoter, which has been reported to correlate with the risk of carotid atherosclerosis. We conducted a hospital-based case–control study of 309 patients with ischemic stroke and 309 controls matched on age and gender. The frequencies of ECE-1b-338 CC, CA, and AA genotypes in cases (45.0, 40.4, and 14.6 %) were significantly different from those of controls (53.1, 39.1, and 7.8 %,
χ
2
= 8.519,
P
= 0.014), respectively. Compared with C carriers, A alleles showed correlation with a 42 % increased risk of ischemic stroke (adjusted odds ratio (OR) = 1.42, 95 % CI = 1.11–1.81). After adjustment for potential risk factors, the AA genotype still kept positive correlation with ischemic stroke (OR = 1.78; 95 % CI = 1.06–3.54). In stratified analyses, the significant association of the A allele with ischemic stroke was observed in female subjects (adjusted OR = 1.64, 95 % CI = 1.17–2.89) and the subjects with age ≥64 years old (adjusted OR = 2.09, 95 % CI = 1.38–3.23). The present study suggested that the C-338A polymorphism of the ECE-1b gene was associated with an increased risk of ischemic stroke in the Chinese Han population.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Alleles</subject><subject>Antihypertensives</subject><subject>Aspartic Acid Endopeptidases - genetics</subject><subject>Atherosclerosis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood pressure</subject><subject>Brain Ischemia - diagnosis</subject><subject>Brain Ischemia - genetics</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Cell Biology</subject><subject>China</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Endothelin-Converting Enzymes</subject><subject>Enzymes</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Glucose</subject><subject>Heterozygote</subject><subject>High density lipoprotein</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Ischemia</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Metalloendopeptidases - genetics</subject><subject>Middle Aged</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Proteomics</subject><subject>Risk factors</subject><subject>Sex Factors</subject><subject>Smoking</subject><subject>Smooth muscle</subject><subject>Stroke</subject><subject>Stroke - diagnosis</subject><subject>Stroke - genetics</subject><issn>0895-8696</issn><issn>1559-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkVFr1TAUx4M43HX6AXyRgC--xOUkaZs-Xi7TXRg4dO-lTU_XbG1yTVqlvvrFTb1TZCD4EE7I-Z3_IfwIeQX8HXBenEcQXALjINPhnC1PyAayrGQAef6UbLguM6bzMj8lz2O841yAAv2MnArFRZ6D3pAf2xi9sfVkvaO-oxeu9VOPg3XMePcVw2TdbXr9vozIoKE7JqXe0ms_LKMPh97GkX6zU0_3zgSsI7b0k433a9Q-mh5Ha-jnKfh7pNbRXW8dRqSXtUsRh3n4tfcFOenqIeLLh3pGbt5f3Owu2dXHD_vd9ooZxbOJ1W1eCJPrri1AaZEuDUInOiXaLJMSFYiMa5Ad8lIqRK1rIU3XiFIbWTfyjLw9xh6C_zJjnKrRRoPDUDv0c6xAKSkLwbn6D1RmWmmAIqFvHqF3fg4u_WOlVJYLWa4UHCkTfIwBu-oQ7FiHpQJerS6ro8squaxWl9WSZl4_JM_NiO2fid_yEiCOQEwtd4vhr9X_TP0J092pDg</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Li, Rui</creator><creator>Cui, Min</creator><creator>Zhao, Jin</creator><creator>Yu, Mingming</creator><creator>Ying, Zegang</creator><creator>Zhou, Shiming</creator><creator>Zhou, Huadong</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20131001</creationdate><title>Association of Endothelin-converting Enzyme-1b C-338A Polymorphism with Increased Risk of Ischemic Stroke in Chinese Han Population</title><author>Li, Rui ; Cui, Min ; Zhao, Jin ; Yu, Mingming ; Ying, Zegang ; Zhou, Shiming ; Zhou, Huadong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-ad672c68fd7148268fbe1f2f42d5533e41250813fe0934ee88a23cfb298c3ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Alleles</topic><topic>Antihypertensives</topic><topic>Aspartic Acid Endopeptidases - genetics</topic><topic>Atherosclerosis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood pressure</topic><topic>Brain Ischemia - diagnosis</topic><topic>Brain Ischemia - genetics</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Cell Biology</topic><topic>China</topic><topic>Cholesterol</topic><topic>Diabetes</topic><topic>Endothelin-Converting Enzymes</topic><topic>Enzymes</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Glucose</topic><topic>Heterozygote</topic><topic>High density lipoprotein</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Ischemia</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Metalloendopeptidases - genetics</topic><topic>Middle Aged</topic><topic>Neurochemistry</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Proteomics</topic><topic>Risk factors</topic><topic>Sex Factors</topic><topic>Smoking</topic><topic>Smooth muscle</topic><topic>Stroke</topic><topic>Stroke - diagnosis</topic><topic>Stroke - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Rui</creatorcontrib><creatorcontrib>Cui, Min</creatorcontrib><creatorcontrib>Zhao, Jin</creatorcontrib><creatorcontrib>Yu, Mingming</creatorcontrib><creatorcontrib>Ying, Zegang</creatorcontrib><creatorcontrib>Zhou, Shiming</creatorcontrib><creatorcontrib>Zhou, Huadong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Rui</au><au>Cui, Min</au><au>Zhao, Jin</au><au>Yu, Mingming</au><au>Ying, Zegang</au><au>Zhou, Shiming</au><au>Zhou, Huadong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Endothelin-converting Enzyme-1b C-338A Polymorphism with Increased Risk of Ischemic Stroke in Chinese Han Population</atitle><jtitle>Journal of molecular neuroscience</jtitle><stitle>J Mol Neurosci</stitle><addtitle>J Mol Neurosci</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>51</volume><issue>2</issue><spage>485</spage><epage>492</epage><pages>485-492</pages><issn>0895-8696</issn><eissn>1559-1166</eissn><abstract>Endothelin-converting enzyme-1b (ECE-1b) C-338A is a polymorphism located in ECE-1 gene promoter, which has been reported to correlate with the risk of carotid atherosclerosis. We conducted a hospital-based case–control study of 309 patients with ischemic stroke and 309 controls matched on age and gender. The frequencies of ECE-1b-338 CC, CA, and AA genotypes in cases (45.0, 40.4, and 14.6 %) were significantly different from those of controls (53.1, 39.1, and 7.8 %,
χ
2
= 8.519,
P
= 0.014), respectively. Compared with C carriers, A alleles showed correlation with a 42 % increased risk of ischemic stroke (adjusted odds ratio (OR) = 1.42, 95 % CI = 1.11–1.81). After adjustment for potential risk factors, the AA genotype still kept positive correlation with ischemic stroke (OR = 1.78; 95 % CI = 1.06–3.54). In stratified analyses, the significant association of the A allele with ischemic stroke was observed in female subjects (adjusted OR = 1.64, 95 % CI = 1.17–2.89) and the subjects with age ≥64 years old (adjusted OR = 2.09, 95 % CI = 1.38–3.23). The present study suggested that the C-338A polymorphism of the ECE-1b gene was associated with an increased risk of ischemic stroke in the Chinese Han population.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24026618</pmid><doi>10.1007/s12031-013-0100-y</doi><tpages>8</tpages></addata></record> |
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| subjects | Age Factors Aged Alleles Antihypertensives Aspartic Acid Endopeptidases - genetics Atherosclerosis Biomedical and Life Sciences Biomedicine Blood pressure Brain Ischemia - diagnosis Brain Ischemia - genetics Cardiovascular disease Case-Control Studies Cell Biology China Cholesterol Diabetes Endothelin-Converting Enzymes Enzymes Female Genetic Predisposition to Disease Glucose Heterozygote High density lipoprotein Hospitals Humans Hypertension Ischemia Magnetic resonance imaging Male Metalloendopeptidases - genetics Middle Aged Neurochemistry Neurology Neurosciences Polymorphism Polymorphism, Single Nucleotide Proteomics Risk factors Sex Factors Smoking Smooth muscle Stroke Stroke - diagnosis Stroke - genetics |
| title | Association of Endothelin-converting Enzyme-1b C-338A Polymorphism with Increased Risk of Ischemic Stroke in Chinese Han Population |
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