Anti-inflammatory/regulatory cytokine microenvironment mediated by IL-4 and IL-10 coordinates the immune response in hemophilia A patients infected chronically with Hepatitis C virus
In the past decades patients with hemophilia were infected commonly by hepatitis C virus (HCV) and a significant number of patients are infected chronically. Focusing on the role of the immune system for controlling and or maintaining HCV infection, the leukocyte and cytokine profiles of peripheral...
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| Veröffentlicht in: | Journal of medical virology 2013-06, Vol.85 (6), p.1009-1018 |
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| creator | Pimentel, João Paulo Chaves, Daniel Gonçalves Araújo, Ana Ruth Silva de Araújo, Erbênia Maria Martins da Silva Fraporti, Liziara Neves, Walter Luiz Lima Tarragô, Andrea Monteiro Torres, Katia Luz Gentz, Solange Henschke Lima Teixeira-Carvalho, Andréa Martins-Filho, Olindo Assis Malheiro, Adriana |
| description | In the past decades patients with hemophilia were infected commonly by hepatitis C virus (HCV) and a significant number of patients are infected chronically. Focusing on the role of the immune system for controlling and or maintaining HCV infection, the leukocyte and cytokine profiles of peripheral blood from hemophilia A patients and other patients with and without HCV infection were studied. The results demonstrated that hemophilia A is characterized by a general state of circulating leukocytes activation along with an overall increase in the frequency of IL‐6 and IL‐10 with decrease of IL‐8 and IL‐12. HCV infection of patients with hemophilia A does not influence further the activation state of circulating leukocytes but is accompanied by lower levels of alanine transaminase (ALT) and a prominent anti‐inflammatory/regulatory serum cytokine pattern, mediated by IL‐4 and IL‐10. Additionally, the results demonstrated that hemophilia A patients infected with HCV displaying No/Low antibody response to C33c and C22 have significant lower viral load and higher serum levels of IL‐12 and IL‐4. This finding suggests that the differential RIBA reactivity to C33c/C22 HCV core proteins may have a putative value as a prognostic biomarker for the infection in hemophilia A patients. J. Med. Virol. 85: 1009–1018, 2013. © 2013 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmv.23554 |
| format | Article |
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Focusing on the role of the immune system for controlling and or maintaining HCV infection, the leukocyte and cytokine profiles of peripheral blood from hemophilia A patients and other patients with and without HCV infection were studied. The results demonstrated that hemophilia A is characterized by a general state of circulating leukocytes activation along with an overall increase in the frequency of IL‐6 and IL‐10 with decrease of IL‐8 and IL‐12. HCV infection of patients with hemophilia A does not influence further the activation state of circulating leukocytes but is accompanied by lower levels of alanine transaminase (ALT) and a prominent anti‐inflammatory/regulatory serum cytokine pattern, mediated by IL‐4 and IL‐10. Additionally, the results demonstrated that hemophilia A patients infected with HCV displaying No/Low antibody response to C33c and C22 have significant lower viral load and higher serum levels of IL‐12 and IL‐4. This finding suggests that the differential RIBA reactivity to C33c/C22 HCV core proteins may have a putative value as a prognostic biomarker for the infection in hemophilia A patients. J. Med. Virol. 85: 1009–1018, 2013. © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.23554</identifier><identifier>PMID: 23591975</identifier><identifier>CODEN: JMVIDB</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Alanine transaminase ; Antibodies, Viral - blood ; Antibodies, Viral - immunology ; Biological and medical sciences ; Biomarkers ; Cellular Microenvironment - immunology ; Cytokines ; Female ; Fundamental and applied biological sciences. Psychology ; HCV ; Hemophilia ; hemophilia A ; Hemophilia A - blood ; Hemophilia A - complications ; Hemophilia A - diagnosis ; Hemophilia A - immunology ; Hepacivirus - immunology ; Hepatitis ; Hepatitis C virus ; Hepatitis C, Chronic - blood ; Hepatitis C, Chronic - complications ; Hepatitis C, Chronic - diagnosis ; Hepatitis C, Chronic - immunology ; Human viral diseases ; Humans ; Immunity, Innate ; Immunology ; Infectious diseases ; Interleukin-10 - blood ; Interleukin-10 - immunology ; Interleukin-12 - blood ; Interleukin-12 - immunology ; Interleukin-4 - blood ; Interleukin-4 - immunology ; Interleukin-6 - blood ; Interleukin-6 - immunology ; leukocyte activation ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Proteins ; RIBA ; Viral Core Proteins - immunology ; Viral diseases ; Viral Load ; Virology</subject><ispartof>Journal of medical virology, 2013-06, Vol.85 (6), p.1009-1018</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3694-5d51e23673bb427ab93eb27959f1ae55c7a0fa3532d71fb3bf73660c9a6935ef3</citedby><cites>FETCH-LOGICAL-c3694-5d51e23673bb427ab93eb27959f1ae55c7a0fa3532d71fb3bf73660c9a6935ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.23554$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.23554$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27286688$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23591975$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pimentel, João Paulo</creatorcontrib><creatorcontrib>Chaves, Daniel Gonçalves</creatorcontrib><creatorcontrib>Araújo, Ana Ruth Silva</creatorcontrib><creatorcontrib>de Araújo, Erbênia Maria Martins</creatorcontrib><creatorcontrib>da Silva Fraporti, Liziara</creatorcontrib><creatorcontrib>Neves, Walter Luiz Lima</creatorcontrib><creatorcontrib>Tarragô, Andrea Monteiro</creatorcontrib><creatorcontrib>Torres, Katia Luz</creatorcontrib><creatorcontrib>Gentz, Solange Henschke Lima</creatorcontrib><creatorcontrib>Teixeira-Carvalho, Andréa</creatorcontrib><creatorcontrib>Martins-Filho, Olindo Assis</creatorcontrib><creatorcontrib>Malheiro, Adriana</creatorcontrib><title>Anti-inflammatory/regulatory cytokine microenvironment mediated by IL-4 and IL-10 coordinates the immune response in hemophilia A patients infected chronically with Hepatitis C virus</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>In the past decades patients with hemophilia were infected commonly by hepatitis C virus (HCV) and a significant number of patients are infected chronically. Focusing on the role of the immune system for controlling and or maintaining HCV infection, the leukocyte and cytokine profiles of peripheral blood from hemophilia A patients and other patients with and without HCV infection were studied. The results demonstrated that hemophilia A is characterized by a general state of circulating leukocytes activation along with an overall increase in the frequency of IL‐6 and IL‐10 with decrease of IL‐8 and IL‐12. HCV infection of patients with hemophilia A does not influence further the activation state of circulating leukocytes but is accompanied by lower levels of alanine transaminase (ALT) and a prominent anti‐inflammatory/regulatory serum cytokine pattern, mediated by IL‐4 and IL‐10. Additionally, the results demonstrated that hemophilia A patients infected with HCV displaying No/Low antibody response to C33c and C22 have significant lower viral load and higher serum levels of IL‐12 and IL‐4. This finding suggests that the differential RIBA reactivity to C33c/C22 HCV core proteins may have a putative value as a prognostic biomarker for the infection in hemophilia A patients. J. Med. Virol. 85: 1009–1018, 2013. © 2013 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Alanine transaminase</subject><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - immunology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Cellular Microenvironment - immunology</subject><subject>Cytokines</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HCV</subject><subject>Hemophilia</subject><subject>hemophilia A</subject><subject>Hemophilia A - blood</subject><subject>Hemophilia A - complications</subject><subject>Hemophilia A - diagnosis</subject><subject>Hemophilia A - immunology</subject><subject>Hepacivirus - immunology</subject><subject>Hepatitis</subject><subject>Hepatitis C virus</subject><subject>Hepatitis C, Chronic - blood</subject><subject>Hepatitis C, Chronic - complications</subject><subject>Hepatitis C, Chronic - diagnosis</subject><subject>Hepatitis C, Chronic - immunology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Immunology</subject><subject>Infectious diseases</subject><subject>Interleukin-10 - blood</subject><subject>Interleukin-10 - immunology</subject><subject>Interleukin-12 - blood</subject><subject>Interleukin-12 - immunology</subject><subject>Interleukin-4 - blood</subject><subject>Interleukin-4 - immunology</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - immunology</subject><subject>leukocyte activation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Proteins</subject><subject>RIBA</subject><subject>Viral Core Proteins - immunology</subject><subject>Viral diseases</subject><subject>Viral Load</subject><subject>Virology</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUhiMEokNhwQsgSwgJFun4EtvxchhBLxqKkLgsLSdxGE9je7CdlrwYz4enMy0SEmLlY53v_OfyF8VzBE8QhHi-sdcnmFBaPShmCApWCsjRw2IGUcVKxhA9Kp7EuIEQ1gLjx8VRhgUSnM6KXwuXTGlcPyhrVfJhmgf9fRxuQ9BOyV8Zp4E1bfDaXZvgndUuAas7o5LuQDOB81VZAeW6XYAgaL0PnXE5G0Faa2CsHbNE0HHrXcx_B9ba-u3aDEaBBdiqZLJkzIletzvNdp3bmFYNwwRuTFqDM72DkolgCfIMY3xaPOrVEPWzw3tcfHn_7vPyrFx9PD1fLlZlS5ioStpRpDFhnDRNhblqBNEN5oKKHilNacsV7BWhBHcc9Q1pek4Yg61QTBCqe3JcvN7rboP_MeqYpDWx1cOgnPZjlKiqCOFIYPF_lOCaVhWuWUZf_oVu_BhcXiQLkhpxxgTN1Js9lU8fY9C93AZjVZgkgnLnu8y-y1vfM_vioDg22Zp78s7oDLw6ACrmw_ZBudbEPxzPc7G6ztx8z92YQU__7igvPny9a13uK0xM-ud9hQpXMt-dU_nt8lSKiqOLT5cr-Zb8Boof1Xk</recordid><startdate>201306</startdate><enddate>201306</enddate><creator>Pimentel, João Paulo</creator><creator>Chaves, Daniel Gonçalves</creator><creator>Araújo, Ana Ruth Silva</creator><creator>de Araújo, Erbênia Maria Martins</creator><creator>da Silva Fraporti, Liziara</creator><creator>Neves, Walter Luiz Lima</creator><creator>Tarragô, Andrea Monteiro</creator><creator>Torres, Katia Luz</creator><creator>Gentz, Solange Henschke Lima</creator><creator>Teixeira-Carvalho, Andréa</creator><creator>Martins-Filho, Olindo Assis</creator><creator>Malheiro, Adriana</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7T5</scope></search><sort><creationdate>201306</creationdate><title>Anti-inflammatory/regulatory cytokine microenvironment mediated by IL-4 and IL-10 coordinates the immune response in hemophilia A patients infected chronically with Hepatitis C virus</title><author>Pimentel, João Paulo ; Chaves, Daniel Gonçalves ; Araújo, Ana Ruth Silva ; de Araújo, Erbênia Maria Martins ; da Silva Fraporti, Liziara ; Neves, Walter Luiz Lima ; Tarragô, Andrea Monteiro ; Torres, Katia Luz ; Gentz, Solange Henschke Lima ; Teixeira-Carvalho, Andréa ; Martins-Filho, Olindo Assis ; Malheiro, Adriana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3694-5d51e23673bb427ab93eb27959f1ae55c7a0fa3532d71fb3bf73660c9a6935ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Alanine transaminase</topic><topic>Antibodies, Viral - blood</topic><topic>Antibodies, Viral - immunology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Cellular Microenvironment - immunology</topic><topic>Cytokines</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HCV</topic><topic>Hemophilia</topic><topic>hemophilia A</topic><topic>Hemophilia A - blood</topic><topic>Hemophilia A - complications</topic><topic>Hemophilia A - diagnosis</topic><topic>Hemophilia A - immunology</topic><topic>Hepacivirus - immunology</topic><topic>Hepatitis</topic><topic>Hepatitis C virus</topic><topic>Hepatitis C, Chronic - blood</topic><topic>Hepatitis C, Chronic - complications</topic><topic>Hepatitis C, Chronic - diagnosis</topic><topic>Hepatitis C, Chronic - immunology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>Immunology</topic><topic>Infectious diseases</topic><topic>Interleukin-10 - blood</topic><topic>Interleukin-10 - immunology</topic><topic>Interleukin-12 - blood</topic><topic>Interleukin-12 - immunology</topic><topic>Interleukin-4 - blood</topic><topic>Interleukin-4 - immunology</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-6 - immunology</topic><topic>leukocyte activation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Proteins</topic><topic>RIBA</topic><topic>Viral Core Proteins - immunology</topic><topic>Viral diseases</topic><topic>Viral Load</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pimentel, João Paulo</creatorcontrib><creatorcontrib>Chaves, Daniel Gonçalves</creatorcontrib><creatorcontrib>Araújo, Ana Ruth Silva</creatorcontrib><creatorcontrib>de Araújo, Erbênia Maria Martins</creatorcontrib><creatorcontrib>da Silva Fraporti, Liziara</creatorcontrib><creatorcontrib>Neves, Walter Luiz Lima</creatorcontrib><creatorcontrib>Tarragô, Andrea Monteiro</creatorcontrib><creatorcontrib>Torres, Katia Luz</creatorcontrib><creatorcontrib>Gentz, Solange Henschke Lima</creatorcontrib><creatorcontrib>Teixeira-Carvalho, Andréa</creatorcontrib><creatorcontrib>Martins-Filho, Olindo Assis</creatorcontrib><creatorcontrib>Malheiro, Adriana</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pimentel, João Paulo</au><au>Chaves, Daniel Gonçalves</au><au>Araújo, Ana Ruth Silva</au><au>de Araújo, Erbênia Maria Martins</au><au>da Silva Fraporti, Liziara</au><au>Neves, Walter Luiz Lima</au><au>Tarragô, Andrea Monteiro</au><au>Torres, Katia Luz</au><au>Gentz, Solange Henschke Lima</au><au>Teixeira-Carvalho, Andréa</au><au>Martins-Filho, Olindo Assis</au><au>Malheiro, Adriana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory/regulatory cytokine microenvironment mediated by IL-4 and IL-10 coordinates the immune response in hemophilia A patients infected chronically with Hepatitis C virus</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>2013-06</date><risdate>2013</risdate><volume>85</volume><issue>6</issue><spage>1009</spage><epage>1018</epage><pages>1009-1018</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><coden>JMVIDB</coden><abstract>In the past decades patients with hemophilia were infected commonly by hepatitis C virus (HCV) and a significant number of patients are infected chronically. Focusing on the role of the immune system for controlling and or maintaining HCV infection, the leukocyte and cytokine profiles of peripheral blood from hemophilia A patients and other patients with and without HCV infection were studied. The results demonstrated that hemophilia A is characterized by a general state of circulating leukocytes activation along with an overall increase in the frequency of IL‐6 and IL‐10 with decrease of IL‐8 and IL‐12. HCV infection of patients with hemophilia A does not influence further the activation state of circulating leukocytes but is accompanied by lower levels of alanine transaminase (ALT) and a prominent anti‐inflammatory/regulatory serum cytokine pattern, mediated by IL‐4 and IL‐10. Additionally, the results demonstrated that hemophilia A patients infected with HCV displaying No/Low antibody response to C33c and C22 have significant lower viral load and higher serum levels of IL‐12 and IL‐4. This finding suggests that the differential RIBA reactivity to C33c/C22 HCV core proteins may have a putative value as a prognostic biomarker for the infection in hemophilia A patients. J. Med. Virol. 85: 1009–1018, 2013. © 2013 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>23591975</pmid><doi>10.1002/jmv.23554</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of medical virology, 2013-06, Vol.85 (6), p.1009-1018 |
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| subjects | Adult Alanine transaminase Antibodies, Viral - blood Antibodies, Viral - immunology Biological and medical sciences Biomarkers Cellular Microenvironment - immunology Cytokines Female Fundamental and applied biological sciences. Psychology HCV Hemophilia hemophilia A Hemophilia A - blood Hemophilia A - complications Hemophilia A - diagnosis Hemophilia A - immunology Hepacivirus - immunology Hepatitis Hepatitis C virus Hepatitis C, Chronic - blood Hepatitis C, Chronic - complications Hepatitis C, Chronic - diagnosis Hepatitis C, Chronic - immunology Human viral diseases Humans Immunity, Innate Immunology Infectious diseases Interleukin-10 - blood Interleukin-10 - immunology Interleukin-12 - blood Interleukin-12 - immunology Interleukin-4 - blood Interleukin-4 - immunology Interleukin-6 - blood Interleukin-6 - immunology leukocyte activation Male Medical sciences Microbiology Middle Aged Miscellaneous Proteins RIBA Viral Core Proteins - immunology Viral diseases Viral Load Virology |
| title | Anti-inflammatory/regulatory cytokine microenvironment mediated by IL-4 and IL-10 coordinates the immune response in hemophilia A patients infected chronically with Hepatitis C virus |
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