Assessment of Therapeutic Potential of Amantadine in Methamphetamine Induced Neurotoxicity

Methamphetamine epidemic has a broad impact on world’s health care system. Its abusive potential and neurotoxic effects remain a challenge for the anti-addiction therapies. In addition to oxidative stress, mitochondrial dysfunction and apoptosis, excitotoxicity is also involved in methamphetamine in...

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Veröffentlicht in:	Neurochemical research 2013-10, Vol.38 (10), p.2084-2094
Hauptverfasser:	Thrash-Williams, Bessy, Ahuja, Manuj, Karuppagounder, Senthilkumar S., Uthayathas, Subramaniam, Suppiramaniam, Vishnu, Dhanasekaran, Muralikrishnan
Format:	Artikel
Sprache:	eng
Schlagworte:	Akinesia Amantadine - therapeutic use Animals Behavior, Animal - drug effects Biochemistry Biomedical and Life Sciences Biomedicine Catalepsy - chemically induced Cell Biology Dopamine - metabolism Male Methamphetamine - poisoning Mice Mice, Inbred C57BL Mitochondrial Diseases - chemically induced Neostriatum - drug effects Neostriatum - metabolism Neurochemistry Neurology Neurosciences Neurotoxicity Syndromes - drug therapy Original Paper Reactive Oxygen Species - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Serotonin - metabolism Superoxide Dismutase - metabolism
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