Diphenyl Diselenide Prevents Cortico-cerebral Mitochondrial Dysfunction and Oxidative Stress Induced by Hypercholesterolemia in LDL Receptor Knockout Mice

Recent studies have indicated a causal link between high dietary cholesterol intake and brain oxidative stress. In particular, we have previously shown a positive correlation between elevated plasma cholesterol levels, cortico-cerebral oxidative stress and mitochondrial dysfunction in low density li...

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Veröffentlicht in:	Neurochemical research 2013-10, Vol.38 (10), p.2028-2036
Hauptverfasser:	de Oliveira, Jade, Moreira, Eduardo Luiz Gasnhar, Mancini, Gianni, Hort, Mariana Appel, Latini, Alexandra, Ribeiro-do-Valle, Rosa Maria, Farina, Marcelo, da Rocha, João Batista Teixeira, de Bem, Andreza Fabro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Benzene Derivatives - therapeutic use Biochemistry Biomedical and Life Sciences Biomedicine Brain - drug effects Cell Biology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cholesterol - blood Cholesterol, Dietary - administration & dosage Electron Transport Complex I - metabolism Electron Transport Complex II - metabolism Glutathione - metabolism Glutathione Peroxidase - metabolism Hypercholesterolemia - physiopathology Male Mice Mice, Knockout Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Diseases - prevention & control Neurochemistry Neurology Neuroprotective Agents - therapeutic use Neurosciences Organoselenium Compounds - therapeutic use Original Paper Oxidative Stress - drug effects Receptors, LDL - deficiency
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