Effects of bilateral lesion of the locus coeruleus and of neonatal administration of 6-hydroxydopamine on the concentration of individual proteins in rat brain
The role that norepinephrine plays in regulating the concentration of different proteins in the parietal cortex, hippocampus and cerebellum was assessed by investigating the effects of either a bilateral lesion of the locus coeruleus or neonatal administration of 6-hydroxydopamine. Two weeks after l...
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| Veröffentlicht in: | Brain research 1986-03, Vol.367 (1), p.31-38 |
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| creator | Heydorn, William E. Nguyen, Khanh Q. Joseph Creed, G. Kostrzewa, Richard M. Jacobowitz, David M. |
| description | The role that norepinephrine plays in regulating the concentration of different proteins in the parietal cortex, hippocampus and cerebellum was assessed by investigating the effects of either a bilateral lesion of the locus coeruleus or neonatal administration of 6-hydroxydopamine. Two weeks after lesioning the locus coeruleus, the concentration of two different proteins was elevated in the hippocampus; a third protein was reduced in concentration in this brain area as a result of the lesion. Three proteins were affected in concentration in the cerebellum after the locus coeruleus lesion — two were elevated in concentration and one was reduced in concentration. No proteins were altered in concentration in the parietal cortex as a result of the lesion. Seventy days after neonatal treatment with 6-hydroxydopamine, a total of 6 proteins were found to be changed. Four of these (one in the hippocampus and 3 in the parietal cortex) were reduced in concentration while two proteins (both in the cerebellum) were elevated in concentration after neonatal treatment with the catecholamine neurotoxin. There was little overlap between those proteins affected in concentration by the bilateral lesion of the locus coeruleus and those changed by neonatal treatment with 6-hydroxydopamine. These results suggest that the concentration of a number of different proteins may, under normal physiological conditions, be regulated in vivo by norepinephrine in the brain. |
| doi_str_mv | 10.1016/0006-8993(86)91575-1 |
| format | Article |
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Two weeks after lesioning the locus coeruleus, the concentration of two different proteins was elevated in the hippocampus; a third protein was reduced in concentration in this brain area as a result of the lesion. Three proteins were affected in concentration in the cerebellum after the locus coeruleus lesion — two were elevated in concentration and one was reduced in concentration. No proteins were altered in concentration in the parietal cortex as a result of the lesion. Seventy days after neonatal treatment with 6-hydroxydopamine, a total of 6 proteins were found to be changed. Four of these (one in the hippocampus and 3 in the parietal cortex) were reduced in concentration while two proteins (both in the cerebellum) were elevated in concentration after neonatal treatment with the catecholamine neurotoxin. There was little overlap between those proteins affected in concentration by the bilateral lesion of the locus coeruleus and those changed by neonatal treatment with 6-hydroxydopamine. These results suggest that the concentration of a number of different proteins may, under normal physiological conditions, be regulated in vivo by norepinephrine in the brain.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(86)91575-1</identifier><identifier>PMID: 3084037</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Animals, Newborn ; Biological and medical sciences ; Brain Chemistry - drug effects ; Central nervous system ; central nervous system protein ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Cerebellum - analysis ; Fundamental and applied biological sciences. Psychology ; Hippocampus - analysis ; Hydroxydopamines - pharmacology ; Locus Coeruleus - physiology ; locus coeruleus lesion ; Male ; neonatal 6-hydroxydopamine ; Nerve Tissue Proteins - analysis ; norepinephrine ; Norepinephrine - physiology ; Oxidopamine ; Parietal Lobe - analysis ; Rats ; Rats, Inbred Strains ; scanning densitometry ; two-dimensional gel electrophoresis ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1986-03, Vol.367 (1), p.31-38</ispartof><rights>1986 Elsevier Science Publishers B.V. (Biomedical Division)</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-c7683a5e97a397cbbb341b9135231a07eb5e7c477163d3be031e98357865d4103</citedby><cites>FETCH-LOGICAL-c417t-c7683a5e97a397cbbb341b9135231a07eb5e7c477163d3be031e98357865d4103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(86)91575-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8735085$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3084037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heydorn, William E.</creatorcontrib><creatorcontrib>Nguyen, Khanh Q.</creatorcontrib><creatorcontrib>Joseph Creed, G.</creatorcontrib><creatorcontrib>Kostrzewa, Richard M.</creatorcontrib><creatorcontrib>Jacobowitz, David M.</creatorcontrib><title>Effects of bilateral lesion of the locus coeruleus and of neonatal administration of 6-hydroxydopamine on the concentration of individual proteins in rat brain</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The role that norepinephrine plays in regulating the concentration of different proteins in the parietal cortex, hippocampus and cerebellum was assessed by investigating the effects of either a bilateral lesion of the locus coeruleus or neonatal administration of 6-hydroxydopamine. Two weeks after lesioning the locus coeruleus, the concentration of two different proteins was elevated in the hippocampus; a third protein was reduced in concentration in this brain area as a result of the lesion. Three proteins were affected in concentration in the cerebellum after the locus coeruleus lesion — two were elevated in concentration and one was reduced in concentration. No proteins were altered in concentration in the parietal cortex as a result of the lesion. Seventy days after neonatal treatment with 6-hydroxydopamine, a total of 6 proteins were found to be changed. Four of these (one in the hippocampus and 3 in the parietal cortex) were reduced in concentration while two proteins (both in the cerebellum) were elevated in concentration after neonatal treatment with the catecholamine neurotoxin. There was little overlap between those proteins affected in concentration by the bilateral lesion of the locus coeruleus and those changed by neonatal treatment with 6-hydroxydopamine. These results suggest that the concentration of a number of different proteins may, under normal physiological conditions, be regulated in vivo by norepinephrine in the brain.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Brain Chemistry - drug effects</subject><subject>Central nervous system</subject><subject>central nervous system protein</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Cerebellum - analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus - analysis</subject><subject>Hydroxydopamines - pharmacology</subject><subject>Locus Coeruleus - physiology</subject><subject>locus coeruleus lesion</subject><subject>Male</subject><subject>neonatal 6-hydroxydopamine</subject><subject>Nerve Tissue Proteins - analysis</subject><subject>norepinephrine</subject><subject>Norepinephrine - physiology</subject><subject>Oxidopamine</subject><subject>Parietal Lobe - analysis</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>scanning densitometry</subject><subject>two-dimensional gel electrophoresis</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9uFSEUxonR1NvqG2gyC2N0MRUuMDAbE9O01qRJN7om_DmTYrhwBabxPk1fVcY7uXHlCjjf75wcvg-hNwRfEkyGTxjjoZfjSD_I4eNIuOA9eYY2RIptP2wZfo42J-QlOi_lZ3tSOuIzdEaxZJiKDXq6niawtXRp6owPukLWoQtQfIpLrT5AF5KdS2cT5DlAu-noFilCiro2Wrudj77UrOvaNfQPB5fT74NLe91E6Fp9GWVTtBD_IX10_tG7uY3Z51TBx9JqXQM6k7WPr9CLSYcCr9fzAv24uf5-ddvf3X_9dvXlrreMiNpbMUiqOYxC01FYYwxlxIyE8i0lGgswHIRlQpCBOmoAUwKjpFzIgTtGML1A749z2xa_ZihV7XyxEIJu35yLIoxRyvACsiNocyolw6T22e90PiiC1ZKLWkxXi-lKDupvLoq0trfr_NnswJ2a1iCa_m7VdbE6TFlH68sJk4JyLHnDPh8xaF48esiqWA_NU-dzi1G55P-_xx_klqu3</recordid><startdate>19860305</startdate><enddate>19860305</enddate><creator>Heydorn, William E.</creator><creator>Nguyen, Khanh Q.</creator><creator>Joseph Creed, G.</creator><creator>Kostrzewa, Richard M.</creator><creator>Jacobowitz, David M.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19860305</creationdate><title>Effects of bilateral lesion of the locus coeruleus and of neonatal administration of 6-hydroxydopamine on the concentration of individual proteins in rat brain</title><author>Heydorn, William E. ; Nguyen, Khanh Q. ; Joseph Creed, G. ; Kostrzewa, Richard M. ; Jacobowitz, David M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-c7683a5e97a397cbbb341b9135231a07eb5e7c477163d3be031e98357865d4103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Brain Chemistry - drug effects</topic><topic>Central nervous system</topic><topic>central nervous system protein</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Cerebellum - analysis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus - analysis</topic><topic>Hydroxydopamines - pharmacology</topic><topic>Locus Coeruleus - physiology</topic><topic>locus coeruleus lesion</topic><topic>Male</topic><topic>neonatal 6-hydroxydopamine</topic><topic>Nerve Tissue Proteins - analysis</topic><topic>norepinephrine</topic><topic>Norepinephrine - physiology</topic><topic>Oxidopamine</topic><topic>Parietal Lobe - analysis</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>scanning densitometry</topic><topic>two-dimensional gel electrophoresis</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heydorn, William E.</creatorcontrib><creatorcontrib>Nguyen, Khanh Q.</creatorcontrib><creatorcontrib>Joseph Creed, G.</creatorcontrib><creatorcontrib>Kostrzewa, Richard M.</creatorcontrib><creatorcontrib>Jacobowitz, David M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heydorn, William E.</au><au>Nguyen, Khanh Q.</au><au>Joseph Creed, G.</au><au>Kostrzewa, Richard M.</au><au>Jacobowitz, David M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of bilateral lesion of the locus coeruleus and of neonatal administration of 6-hydroxydopamine on the concentration of individual proteins in rat brain</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1986-03-05</date><risdate>1986</risdate><volume>367</volume><issue>1</issue><spage>31</spage><epage>38</epage><pages>31-38</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The role that norepinephrine plays in regulating the concentration of different proteins in the parietal cortex, hippocampus and cerebellum was assessed by investigating the effects of either a bilateral lesion of the locus coeruleus or neonatal administration of 6-hydroxydopamine. Two weeks after lesioning the locus coeruleus, the concentration of two different proteins was elevated in the hippocampus; a third protein was reduced in concentration in this brain area as a result of the lesion. Three proteins were affected in concentration in the cerebellum after the locus coeruleus lesion — two were elevated in concentration and one was reduced in concentration. No proteins were altered in concentration in the parietal cortex as a result of the lesion. Seventy days after neonatal treatment with 6-hydroxydopamine, a total of 6 proteins were found to be changed. Four of these (one in the hippocampus and 3 in the parietal cortex) were reduced in concentration while two proteins (both in the cerebellum) were elevated in concentration after neonatal treatment with the catecholamine neurotoxin. There was little overlap between those proteins affected in concentration by the bilateral lesion of the locus coeruleus and those changed by neonatal treatment with 6-hydroxydopamine. These results suggest that the concentration of a number of different proteins may, under normal physiological conditions, be regulated in vivo by norepinephrine in the brain.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>3084037</pmid><doi>10.1016/0006-8993(86)91575-1</doi><tpages>8</tpages></addata></record> |
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| ispartof | Brain research, 1986-03, Vol.367 (1), p.31-38 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Animals, Newborn Biological and medical sciences Brain Chemistry - drug effects Central nervous system central nervous system protein Central neurotransmission. Neuromudulation. Pathways and receptors Cerebellum - analysis Fundamental and applied biological sciences. Psychology Hippocampus - analysis Hydroxydopamines - pharmacology Locus Coeruleus - physiology locus coeruleus lesion Male neonatal 6-hydroxydopamine Nerve Tissue Proteins - analysis norepinephrine Norepinephrine - physiology Oxidopamine Parietal Lobe - analysis Rats Rats, Inbred Strains scanning densitometry two-dimensional gel electrophoresis Vertebrates: nervous system and sense organs |
| title | Effects of bilateral lesion of the locus coeruleus and of neonatal administration of 6-hydroxydopamine on the concentration of individual proteins in rat brain |
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