Partition Coefficients between Human Blood or Adipose Tissue and Air for Aromatic Solvents
Objectives The partitioning of lipophilic toxicants into blood and into adipose tissue plays an important role in the physiological distribution and toxicology of these substances. The partition coefficients between blood and air and adipose tissue and air were determined for widely used aromatic so...
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| Veröffentlicht in: | Scandinavian Journal of Work, Environment ＆ Health Environment ＆ Health, 1996-04, Vol.22 (2), p.112-118+vi |
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| container_end_page | 118+vi |
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| container_title | Scandinavian Journal of Work, Environment ＆ Health |
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| creator | Pierce, Crispin H Dills, Russell L Silvey, Guy W Kalman, David A |
| description | Objectives The partitioning of lipophilic toxicants into blood and into adipose tissue plays an important role in the physiological distribution and toxicology of these substances. The partition coefficients between blood and air and adipose tissue and air were determined for widely used aromatic solvents in an in vitro test system using human tissue samples. Methods Samples of whole venous blood (N = 35) were drawn from 10 subjects. In addition, samples of perirenal and epididymal adipose tissue were obtained from F344 rats, along with subcutaneous, omental, or inguinal adipose tissue from 43 patients who had undergone surgery. Portions of each tissue were injected into vials for equilibration with atmospheres containing deuterated and nondeuterated organic solvents. Gas Chromatographie headspace analysis was then used to determine the partition coefficients between blood and air and adipose tissue and air. Results The mean partition coefficients between human blood and air or adipose tissue and air were 334 (SE 11) (adipose tissue) for benzene; 1764 (SE 49) (adipose tissue) for ethylbenzene; 3184 (SE 84) (adipose tissue) for styrene; 18.3 (SE 0.24) (blood) and 962 (SE 32) (adipose tissue) for toluene; 35.2 (SE 0.45) (blood) and 2460 (SE 63) (adipose tissue) for o-xylene; 31.9 (SE 0.45) (blood) and 1919 (SE 53) (adipose tissue) for m-xylene; and 39.0 (SE 0.70) (blood) and 2019 (SE 102) forp-xylene. Regression analyses revealed coefficients of determination of 0.88 (human) and 0.98 (rat) between blood and air and log tissue and air. A value of 0.98 was found for partition coefficients between rat and human adipose tissue. Conclusions The partition coefficients between blood and air and adipose tissue and air were strongly correlated. The partitioning of aromatic solvents into rat adipose tissue is predictive of partitioning into human adipose tissue. |
| doi_str_mv | 10.5271/sjweh.119 |
| format | Article |
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The partition coefficients between blood and air and adipose tissue and air were determined for widely used aromatic solvents in an in vitro test system using human tissue samples. Methods Samples of whole venous blood (N = 35) were drawn from 10 subjects. In addition, samples of perirenal and epididymal adipose tissue were obtained from F344 rats, along with subcutaneous, omental, or inguinal adipose tissue from 43 patients who had undergone surgery. Portions of each tissue were injected into vials for equilibration with atmospheres containing deuterated and nondeuterated organic solvents. Gas Chromatographie headspace analysis was then used to determine the partition coefficients between blood and air and adipose tissue and air. Results The mean partition coefficients between human blood and air or adipose tissue and air were 334 (SE 11) (adipose tissue) for benzene; 1764 (SE 49) (adipose tissue) for ethylbenzene; 3184 (SE 84) (adipose tissue) for styrene; 18.3 (SE 0.24) (blood) and 962 (SE 32) (adipose tissue) for toluene; 35.2 (SE 0.45) (blood) and 2460 (SE 63) (adipose tissue) for o-xylene; 31.9 (SE 0.45) (blood) and 1919 (SE 53) (adipose tissue) for m-xylene; and 39.0 (SE 0.70) (blood) and 2019 (SE 102) forp-xylene. Regression analyses revealed coefficients of determination of 0.88 (human) and 0.98 (rat) between blood and air and log tissue and air. A value of 0.98 was found for partition coefficients between rat and human adipose tissue. Conclusions The partition coefficients between blood and air and adipose tissue and air were strongly correlated. The partitioning of aromatic solvents into rat adipose tissue is predictive of partitioning into human adipose tissue.</description><identifier>ISSN: 0355-3140</identifier><identifier>EISSN: 1795-990X</identifier><identifier>DOI: 10.5271/sjweh.119</identifier><identifier>PMID: 8738889</identifier><language>eng</language><publisher>Helsinki: Scandinavian Journal of Work, Environment ＆ Health</publisher><subject>Adipose Tissue - chemistry ; Adipose tissues ; Air - analysis ; Air Pollutants - analysis ; Air Pollutants - pharmacokinetics ; Animals ; Benzene - analysis ; Benzene - pharmacokinetics ; Benzene Derivatives - analysis ; Benzene Derivatives - pharmacokinetics ; Biological and medical sciences ; Blood ; Chemical and industrial products toxicology. Toxic occupational diseases ; Chemical hazards ; Coefficients ; Constant coefficients ; Deuterium - analysis ; Deuterium - pharmacokinetics ; Humans ; In Vitro Techniques ; Isomerism ; Male ; Medical sciences ; Pharmacokinetics ; Rats ; Rats, Inbred F344 ; Solvents ; Solvents - analysis ; Solvents - pharmacokinetics ; Styrenes ; Styrenes - analysis ; Styrenes - pharmacokinetics ; Tissue samples ; Toluene - analysis ; Toluene - pharmacokinetics ; Toxicants ; Toxicology ; Xylenes - analysis ; Xylenes - pharmacokinetics</subject><ispartof>Scandinavian Journal of Work, Environment ＆ Health, 1996-04, Vol.22 (2), p.112-118+vi</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a573t-1ba57b6aa01594a92d27eb52fd0543e5c1dc55577839da497dbe0e730e0f16d03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40966518$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40966518$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3216798$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8738889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pierce, Crispin H</creatorcontrib><creatorcontrib>Dills, Russell L</creatorcontrib><creatorcontrib>Silvey, Guy W</creatorcontrib><creatorcontrib>Kalman, David A</creatorcontrib><title>Partition Coefficients between Human Blood or Adipose Tissue and Air for Aromatic Solvents</title><title>Scandinavian Journal of Work, Environment ＆ Health</title><addtitle>Scand J Work Environ Health</addtitle><description>Objectives The partitioning of lipophilic toxicants into blood and into adipose tissue plays an important role in the physiological distribution and toxicology of these substances. The partition coefficients between blood and air and adipose tissue and air were determined for widely used aromatic solvents in an in vitro test system using human tissue samples. Methods Samples of whole venous blood (N = 35) were drawn from 10 subjects. In addition, samples of perirenal and epididymal adipose tissue were obtained from F344 rats, along with subcutaneous, omental, or inguinal adipose tissue from 43 patients who had undergone surgery. Portions of each tissue were injected into vials for equilibration with atmospheres containing deuterated and nondeuterated organic solvents. Gas Chromatographie headspace analysis was then used to determine the partition coefficients between blood and air and adipose tissue and air. Results The mean partition coefficients between human blood and air or adipose tissue and air were 334 (SE 11) (adipose tissue) for benzene; 1764 (SE 49) (adipose tissue) for ethylbenzene; 3184 (SE 84) (adipose tissue) for styrene; 18.3 (SE 0.24) (blood) and 962 (SE 32) (adipose tissue) for toluene; 35.2 (SE 0.45) (blood) and 2460 (SE 63) (adipose tissue) for o-xylene; 31.9 (SE 0.45) (blood) and 1919 (SE 53) (adipose tissue) for m-xylene; and 39.0 (SE 0.70) (blood) and 2019 (SE 102) forp-xylene. Regression analyses revealed coefficients of determination of 0.88 (human) and 0.98 (rat) between blood and air and log tissue and air. A value of 0.98 was found for partition coefficients between rat and human adipose tissue. Conclusions The partition coefficients between blood and air and adipose tissue and air were strongly correlated. The partitioning of aromatic solvents into rat adipose tissue is predictive of partitioning into human adipose tissue.</description><subject>Adipose Tissue - chemistry</subject><subject>Adipose tissues</subject><subject>Air - analysis</subject><subject>Air Pollutants - analysis</subject><subject>Air Pollutants - pharmacokinetics</subject><subject>Animals</subject><subject>Benzene - analysis</subject><subject>Benzene - pharmacokinetics</subject><subject>Benzene Derivatives - analysis</subject><subject>Benzene Derivatives - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chemical hazards</subject><subject>Coefficients</subject><subject>Constant coefficients</subject><subject>Deuterium - analysis</subject><subject>Deuterium - pharmacokinetics</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Isomerism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacokinetics</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Solvents</subject><subject>Solvents - analysis</subject><subject>Solvents - pharmacokinetics</subject><subject>Styrenes</subject><subject>Styrenes - analysis</subject><subject>Styrenes - pharmacokinetics</subject><subject>Tissue samples</subject><subject>Toluene - analysis</subject><subject>Toluene - pharmacokinetics</subject><subject>Toxicants</subject><subject>Toxicology</subject><subject>Xylenes - analysis</subject><subject>Xylenes - pharmacokinetics</subject><issn>0355-3140</issn><issn>1795-990X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkVGL1DAQx4Mo53r64AcQ8iCCDz1nmqZpHtdFPfFAwRPEl5A2U8zSNmvS3uG3N3WXFR-GYfj9-D_8h7HnCFeyVPgm7e_p5xWifsA2qLQstIbvD9kGhJSFwAoesycp7QFKnf0LdtEo0TSN3rAfX2yc_ezDxHeB-t53nqY58Zbme6KJXy-jnfjbIQTHQ-Rb5w8hEb_1KS3E7eT41kferyiG0c6-41_DcLdmPGWPejskenbal-zb-3e3u-vi5vOHj7vtTWGlEnOBbd5tbS2g1JXVpSsVtbLsHchKkOzQdVJKpRqhna20ci0BKQEEPdYOxCV7dcw9xPBroTSb0aeOhsFOFJZksKqwqoXK4uuj2MWQUqTeHKIfbfxtEMzao_nbo8k9ZvfFKXRpR3Jn81Rc5i9P3KbODn20U-fTWRMl1ko3_2L2aQ7xjCvQdS1x5Z-O3PqYv2D2YYlTLsusn1sfZ1DrGoQpIR8SNEBV_38glnkac-fFHxuImdY</recordid><startdate>19960401</startdate><enddate>19960401</enddate><creator>Pierce, Crispin H</creator><creator>Dills, Russell L</creator><creator>Silvey, Guy W</creator><creator>Kalman, David A</creator><general>Scandinavian Journal of Work, Environment ＆ Health</general><general>National Institute for Working Life</general><general>Finnish Institute of Occupational Health</general><general>National Institute of Occupational Health (Denmark)</general><general>National Institute of Occupational Health (Norway)</general><general>Scandinavian journal of work, environment & health</general><scope>188</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>19960401</creationdate><title>Partition Coefficients between Human Blood or Adipose Tissue and Air for Aromatic Solvents</title><author>Pierce, Crispin H ; Dills, Russell L ; Silvey, Guy W ; Kalman, David A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a573t-1ba57b6aa01594a92d27eb52fd0543e5c1dc55577839da497dbe0e730e0f16d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adipose Tissue - chemistry</topic><topic>Adipose tissues</topic><topic>Air - analysis</topic><topic>Air Pollutants - analysis</topic><topic>Air Pollutants - pharmacokinetics</topic><topic>Animals</topic><topic>Benzene - analysis</topic><topic>Benzene - pharmacokinetics</topic><topic>Benzene Derivatives - analysis</topic><topic>Benzene Derivatives - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chemical hazards</topic><topic>Coefficients</topic><topic>Constant coefficients</topic><topic>Deuterium - analysis</topic><topic>Deuterium - pharmacokinetics</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Isomerism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacokinetics</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Solvents</topic><topic>Solvents - analysis</topic><topic>Solvents - pharmacokinetics</topic><topic>Styrenes</topic><topic>Styrenes - analysis</topic><topic>Styrenes - pharmacokinetics</topic><topic>Tissue samples</topic><topic>Toluene - analysis</topic><topic>Toluene - pharmacokinetics</topic><topic>Toxicants</topic><topic>Toxicology</topic><topic>Xylenes - analysis</topic><topic>Xylenes - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pierce, Crispin H</creatorcontrib><creatorcontrib>Dills, Russell L</creatorcontrib><creatorcontrib>Silvey, Guy W</creatorcontrib><creatorcontrib>Kalman, David A</creatorcontrib><collection>Airiti Library</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Scandinavian Journal of Work, Environment ＆ Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pierce, Crispin H</au><au>Dills, Russell L</au><au>Silvey, Guy W</au><au>Kalman, David A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Partition Coefficients between Human Blood or Adipose Tissue and Air for Aromatic Solvents</atitle><jtitle>Scandinavian Journal of Work, Environment ＆ Health</jtitle><addtitle>Scand J Work Environ Health</addtitle><date>1996-04-01</date><risdate>1996</risdate><volume>22</volume><issue>2</issue><spage>112</spage><epage>118+vi</epage><pages>112-118+vi</pages><issn>0355-3140</issn><eissn>1795-990X</eissn><abstract>Objectives The partitioning of lipophilic toxicants into blood and into adipose tissue plays an important role in the physiological distribution and toxicology of these substances. The partition coefficients between blood and air and adipose tissue and air were determined for widely used aromatic solvents in an in vitro test system using human tissue samples. Methods Samples of whole venous blood (N = 35) were drawn from 10 subjects. In addition, samples of perirenal and epididymal adipose tissue were obtained from F344 rats, along with subcutaneous, omental, or inguinal adipose tissue from 43 patients who had undergone surgery. Portions of each tissue were injected into vials for equilibration with atmospheres containing deuterated and nondeuterated organic solvents. Gas Chromatographie headspace analysis was then used to determine the partition coefficients between blood and air and adipose tissue and air. Results The mean partition coefficients between human blood and air or adipose tissue and air were 334 (SE 11) (adipose tissue) for benzene; 1764 (SE 49) (adipose tissue) for ethylbenzene; 3184 (SE 84) (adipose tissue) for styrene; 18.3 (SE 0.24) (blood) and 962 (SE 32) (adipose tissue) for toluene; 35.2 (SE 0.45) (blood) and 2460 (SE 63) (adipose tissue) for o-xylene; 31.9 (SE 0.45) (blood) and 1919 (SE 53) (adipose tissue) for m-xylene; and 39.0 (SE 0.70) (blood) and 2019 (SE 102) forp-xylene. Regression analyses revealed coefficients of determination of 0.88 (human) and 0.98 (rat) between blood and air and log tissue and air. A value of 0.98 was found for partition coefficients between rat and human adipose tissue. Conclusions The partition coefficients between blood and air and adipose tissue and air were strongly correlated. The partitioning of aromatic solvents into rat adipose tissue is predictive of partitioning into human adipose tissue.</abstract><cop>Helsinki</cop><pub>Scandinavian Journal of Work, Environment ＆ Health</pub><pmid>8738889</pmid><doi>10.5271/sjweh.119</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adipose Tissue - chemistry Adipose tissues Air - analysis Air Pollutants - analysis Air Pollutants - pharmacokinetics Animals Benzene - analysis Benzene - pharmacokinetics Benzene Derivatives - analysis Benzene Derivatives - pharmacokinetics Biological and medical sciences Blood Chemical and industrial products toxicology. Toxic occupational diseases Chemical hazards Coefficients Constant coefficients Deuterium - analysis Deuterium - pharmacokinetics Humans In Vitro Techniques Isomerism Male Medical sciences Pharmacokinetics Rats Rats, Inbred F344 Solvents Solvents - analysis Solvents - pharmacokinetics Styrenes Styrenes - analysis Styrenes - pharmacokinetics Tissue samples Toluene - analysis Toluene - pharmacokinetics Toxicants Toxicology Xylenes - analysis Xylenes - pharmacokinetics |
| title | Partition Coefficients between Human Blood or Adipose Tissue and Air for Aromatic Solvents |
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