Methylmercury toxicity in spontaneously hypertensive rats (SHR)

This study was designed to delineate the toxicity of MeHg in animals having high blood pressure using the laboratory model of spontaneously hypertensive rats (SHR). This rodent model was developed for the study of spontaneous hypertension in animals and of essential hypertension in man. This establi...

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Veröffentlicht in:	Bull. Environ. Contam. Toxicol.; (United States) 1986-05, Vol.36 (5), p.668-673
Hauptverfasser:	TAMASHIRO, H, ARAKAKI, M, AKAGI, H, HIRAYAMA, K, SMOLENSKY, M. H
Format:	Artikel
Sprache:	eng
Schlagworte:	560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) ANIMALS Biological and medical sciences BIOLOGICAL EFFECTS Brain - metabolism CARDIOVASCULAR DISEASES Chemical and industrial products toxicology. Toxic occupational diseases CHLORIDES CHLORINE COMPOUNDS DISEASES DISTRIBUTION HALIDES HALOGEN COMPOUNDS HYPERTENSION Hypertension - physiopathology MAMMALS Medical sciences MERCURY CHLORIDES MERCURY COMPOUNDS MERCURY HALIDES Metals and various inorganic compounds METHYLMERCURY Methylmercury Compounds - metabolism Methylmercury Compounds - toxicity MORTALITY ORAL ADMINISTRATION ORGANIC COMPOUNDS ORGANIC MERCURY COMPOUNDS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS Rats, Inbred SHR - physiology Rats, Inbred Strains - physiology RODENTS SYMPTOMS Time Factors TISSUE DISTRIBUTION Toxicology VASCULAR DISEASES VERTEBRATES
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Beschreibung
Zusammenfassung:	This study was designed to delineate the toxicity of MeHg in animals having high blood pressure using the laboratory model of spontaneously hypertensive rats (SHR). This rodent model was developed for the study of spontaneous hypertension in animals and of essential hypertension in man. This established animal model has been used widely for this purpose. This paper presents the mortality as well as distribution mercury in the tissues of SHR and control rats treated orally with methylmercury chloride (MMC: 5 mg/kg/day) for 10 consecutive days.
ISSN:	0007-4861 1432-0800
DOI:	10.1007/bf01623567