Delirium Outcomes in a Randomized Trial of Blood Transfusion Thresholds in Hospitalized Older Adults with Hip Fracture
Objectives To determine whether a higher blood transfusion threshold would prevent new or worsening delirium symptoms in the hospital after hip fracture surgery. Design Ancillary study to a randomized clinical trial. Setting Thirteen hospitals in the United States and Canada. Participants One hundre...
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| Veröffentlicht in: | Journal of the American Geriatrics Society (JAGS) 2013-08, Vol.61 (8), p.1286-1295 |
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| container_title | Journal of the American Geriatrics Society (JAGS) |
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| creator | Gruber-Baldini, Ann L. Marcantonio, Edward Orwig, Denise Magaziner, Jay Terrin, Michael Barr, Erik Brown, Jessica P. Paris, Barbara Zagorin, Aleksandra Roffey, Darren M. Zakriya, Khwaja Blute, Mary-Rita Hebel, J. Richard Carson, Jeffrey L. |
| description | Objectives
To determine whether a higher blood transfusion threshold would prevent new or worsening delirium symptoms in the hospital after hip fracture surgery.
Design
Ancillary study to a randomized clinical trial.
Setting
Thirteen hospitals in the United States and Canada.
Participants
One hundred thirty‐nine individuals hospitalized with hip fracture aged 50 and older (mean age 81.5 ± 9.1) with cardiovascular disease or risk factors and hemoglobin concentrations of less than 10 g/dL within 3 days of surgery recruited in an ancillary study of the Transfusion Trigger Trial for Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair.
Intervention
Individuals in the liberal treatment group received one unit of packed red blood cells and as much blood as needed to maintain hemoglobin concentrations at greater than 10 g/dL; those in the restrictive treatment group received transfusions if they developed symptoms of anemia or their hemoglobin fell below 8 g/dL.
Measurements
Delirium assessments were performed before randomization and up to three times after randomization. The primary outcome was severity of delirium according to the Memorial Delirium Assessment Scale (MDAS). The secondary outcome was the presence or absence of delirium defined according to the Confusion Assessment Method (CAM).
Results
The liberal group received a median two units of blood and the restrictive group zero units of blood. Hemoglobin concentration on Day 1 after randomization was 1.4 g/dL higher in the liberal group. Treatment groups did not differ significantly at any time point or over time on MDAS delirium severity (P = .28) or CAM delirium presence (P = .83).
Conclusion
Blood transfusion to maintain hemoglobin concentrations greater than 10 g/dL alone is unlikely to influence delirium severity or rate in individuals with hip fracture after surgery with a hemoglobin concentration less than 10 g/dL. |
| doi_str_mv | 10.1111/jgs.12396 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1440667182</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1420606553</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4896-ab7acc93aeeaba14e51f8620b4a47d3405fd9962424984772b28f19425085dcf3</originalsourceid><addsrcrecordid>eNqN0U9rFDEYBvBBFLtWD34BCYigh2nzf5Jju213lOKiXfEYspmMmzUzWZOZ1vrpTXe3FQTBXELg9-QleYriJYJHKK_j9bd0hDCR_FExQYzgklHEHhcTCCEuBUf0oHiW0hpChKEQT4sDTIQUQtJJcX1mvYtu7MB8HEzobAKuBxp81n0TOvfLNmARnfYgtODUh3B31H1qx-RCDxaraNMq-GabqkPauEH7bWruGxvBSTP6IYEbN6xA7TbgImozjNE-L5602if7Yr8fFl8uzhfTurycz95PTy5LQ4XkpV5W2hhJtLV6qRG1DLWCY7ikmlYNoZC1jZQcU0yloFWFl1i0SFLMoGCNaclh8XZ37yaGH6NNg-pcMtZ73dswJoUohZxXSOD_oBhyyBkjmb7-i67DGPv8kKzyeCIR5Fm92ykTQ0rRtmoTXafjrUJQ3fWmcm9q21u2r_Y3jsvONg_yvqgM3uyBTkb7NpdgXPrjKs7yP6Dsjnfuxnl7---J6sPs6n50uUu4NNifDwkdvytekYqprx9n6oqefapZPVUz8htS5LzL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1419439106</pqid></control><display><type>article</type><title>Delirium Outcomes in a Randomized Trial of Blood Transfusion Thresholds in Hospitalized Older Adults with Hip Fracture</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Gruber-Baldini, Ann L. ; Marcantonio, Edward ; Orwig, Denise ; Magaziner, Jay ; Terrin, Michael ; Barr, Erik ; Brown, Jessica P. ; Paris, Barbara ; Zagorin, Aleksandra ; Roffey, Darren M. ; Zakriya, Khwaja ; Blute, Mary-Rita ; Hebel, J. Richard ; Carson, Jeffrey L.</creator><creatorcontrib>Gruber-Baldini, Ann L. ; Marcantonio, Edward ; Orwig, Denise ; Magaziner, Jay ; Terrin, Michael ; Barr, Erik ; Brown, Jessica P. ; Paris, Barbara ; Zagorin, Aleksandra ; Roffey, Darren M. ; Zakriya, Khwaja ; Blute, Mary-Rita ; Hebel, J. Richard ; Carson, Jeffrey L.</creatorcontrib><description>Objectives
To determine whether a higher blood transfusion threshold would prevent new or worsening delirium symptoms in the hospital after hip fracture surgery.
Design
Ancillary study to a randomized clinical trial.
Setting
Thirteen hospitals in the United States and Canada.
Participants
One hundred thirty‐nine individuals hospitalized with hip fracture aged 50 and older (mean age 81.5 ± 9.1) with cardiovascular disease or risk factors and hemoglobin concentrations of less than 10 g/dL within 3 days of surgery recruited in an ancillary study of the Transfusion Trigger Trial for Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair.
Intervention
Individuals in the liberal treatment group received one unit of packed red blood cells and as much blood as needed to maintain hemoglobin concentrations at greater than 10 g/dL; those in the restrictive treatment group received transfusions if they developed symptoms of anemia or their hemoglobin fell below 8 g/dL.
Measurements
Delirium assessments were performed before randomization and up to three times after randomization. The primary outcome was severity of delirium according to the Memorial Delirium Assessment Scale (MDAS). The secondary outcome was the presence or absence of delirium defined according to the Confusion Assessment Method (CAM).
Results
The liberal group received a median two units of blood and the restrictive group zero units of blood. Hemoglobin concentration on Day 1 after randomization was 1.4 g/dL higher in the liberal group. Treatment groups did not differ significantly at any time point or over time on MDAS delirium severity (P = .28) or CAM delirium presence (P = .83).
Conclusion
Blood transfusion to maintain hemoglobin concentrations greater than 10 g/dL alone is unlikely to influence delirium severity or rate in individuals with hip fracture after surgery with a hemoglobin concentration less than 10 g/dL.</description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/jgs.12396</identifier><identifier>PMID: 23898894</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Hoboken, NJ: Blackwell Publishing Ltd</publisher><subject>Adult and adolescent clinical studies ; Aged ; Aged, 80 and over ; Biological and medical sciences ; blood transfusion ; Blood Transfusion - methods ; Blood transfusions ; Clinical outcomes ; Delirium ; Delirium - blood ; Delirium - diagnosis ; Delirium - prevention & control ; Erythrocyte Transfusion - methods ; Female ; Fractures ; General aspects ; Hemoglobinometry ; hip fracture ; Hip Fractures - blood ; Hip Fractures - surgery ; Hip joint ; Hospitalization ; Humans ; Male ; Medical sciences ; Mental Status Schedule ; Miscellaneous ; Neuropsychological Tests ; Older people ; Organic mental disorders. Neuropsychology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2013-08, Vol.61 (8), p.1286-1295</ispartof><rights>2013, Copyright the Authors Journal compilation © 2013, The American Geriatrics Society</rights><rights>2015 INIST-CNRS</rights><rights>2013, Copyright the Authors Journal compilation © 2013, The American Geriatrics Society.</rights><rights>2013 American Geriatrics Society and Wiley Periodicals, Inc</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4896-ab7acc93aeeaba14e51f8620b4a47d3405fd9962424984772b28f19425085dcf3</citedby><cites>FETCH-LOGICAL-c4896-ab7acc93aeeaba14e51f8620b4a47d3405fd9962424984772b28f19425085dcf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgs.12396$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgs.12396$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27659621$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23898894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gruber-Baldini, Ann L.</creatorcontrib><creatorcontrib>Marcantonio, Edward</creatorcontrib><creatorcontrib>Orwig, Denise</creatorcontrib><creatorcontrib>Magaziner, Jay</creatorcontrib><creatorcontrib>Terrin, Michael</creatorcontrib><creatorcontrib>Barr, Erik</creatorcontrib><creatorcontrib>Brown, Jessica P.</creatorcontrib><creatorcontrib>Paris, Barbara</creatorcontrib><creatorcontrib>Zagorin, Aleksandra</creatorcontrib><creatorcontrib>Roffey, Darren M.</creatorcontrib><creatorcontrib>Zakriya, Khwaja</creatorcontrib><creatorcontrib>Blute, Mary-Rita</creatorcontrib><creatorcontrib>Hebel, J. Richard</creatorcontrib><creatorcontrib>Carson, Jeffrey L.</creatorcontrib><title>Delirium Outcomes in a Randomized Trial of Blood Transfusion Thresholds in Hospitalized Older Adults with Hip Fracture</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>Objectives
To determine whether a higher blood transfusion threshold would prevent new or worsening delirium symptoms in the hospital after hip fracture surgery.
Design
Ancillary study to a randomized clinical trial.
Setting
Thirteen hospitals in the United States and Canada.
Participants
One hundred thirty‐nine individuals hospitalized with hip fracture aged 50 and older (mean age 81.5 ± 9.1) with cardiovascular disease or risk factors and hemoglobin concentrations of less than 10 g/dL within 3 days of surgery recruited in an ancillary study of the Transfusion Trigger Trial for Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair.
Intervention
Individuals in the liberal treatment group received one unit of packed red blood cells and as much blood as needed to maintain hemoglobin concentrations at greater than 10 g/dL; those in the restrictive treatment group received transfusions if they developed symptoms of anemia or their hemoglobin fell below 8 g/dL.
Measurements
Delirium assessments were performed before randomization and up to three times after randomization. The primary outcome was severity of delirium according to the Memorial Delirium Assessment Scale (MDAS). The secondary outcome was the presence or absence of delirium defined according to the Confusion Assessment Method (CAM).
Results
The liberal group received a median two units of blood and the restrictive group zero units of blood. Hemoglobin concentration on Day 1 after randomization was 1.4 g/dL higher in the liberal group. Treatment groups did not differ significantly at any time point or over time on MDAS delirium severity (P = .28) or CAM delirium presence (P = .83).
Conclusion
Blood transfusion to maintain hemoglobin concentrations greater than 10 g/dL alone is unlikely to influence delirium severity or rate in individuals with hip fracture after surgery with a hemoglobin concentration less than 10 g/dL.</description><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>blood transfusion</subject><subject>Blood Transfusion - methods</subject><subject>Blood transfusions</subject><subject>Clinical outcomes</subject><subject>Delirium</subject><subject>Delirium - blood</subject><subject>Delirium - diagnosis</subject><subject>Delirium - prevention & control</subject><subject>Erythrocyte Transfusion - methods</subject><subject>Female</subject><subject>Fractures</subject><subject>General aspects</subject><subject>Hemoglobinometry</subject><subject>hip fracture</subject><subject>Hip Fractures - blood</subject><subject>Hip Fractures - surgery</subject><subject>Hip joint</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental Status Schedule</subject><subject>Miscellaneous</subject><subject>Neuropsychological Tests</subject><subject>Older people</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0U9rFDEYBvBBFLtWD34BCYigh2nzf5Jju213lOKiXfEYspmMmzUzWZOZ1vrpTXe3FQTBXELg9-QleYriJYJHKK_j9bd0hDCR_FExQYzgklHEHhcTCCEuBUf0oHiW0hpChKEQT4sDTIQUQtJJcX1mvYtu7MB8HEzobAKuBxp81n0TOvfLNmARnfYgtODUh3B31H1qx-RCDxaraNMq-GabqkPauEH7bWruGxvBSTP6IYEbN6xA7TbgImozjNE-L5602if7Yr8fFl8uzhfTurycz95PTy5LQ4XkpV5W2hhJtLV6qRG1DLWCY7ikmlYNoZC1jZQcU0yloFWFl1i0SFLMoGCNaclh8XZ37yaGH6NNg-pcMtZ73dswJoUohZxXSOD_oBhyyBkjmb7-i67DGPv8kKzyeCIR5Fm92ykTQ0rRtmoTXafjrUJQ3fWmcm9q21u2r_Y3jsvONg_yvqgM3uyBTkb7NpdgXPrjKs7yP6Dsjnfuxnl7---J6sPs6n50uUu4NNifDwkdvytekYqprx9n6oqefapZPVUz8htS5LzL</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Gruber-Baldini, Ann L.</creator><creator>Marcantonio, Edward</creator><creator>Orwig, Denise</creator><creator>Magaziner, Jay</creator><creator>Terrin, Michael</creator><creator>Barr, Erik</creator><creator>Brown, Jessica P.</creator><creator>Paris, Barbara</creator><creator>Zagorin, Aleksandra</creator><creator>Roffey, Darren M.</creator><creator>Zakriya, Khwaja</creator><creator>Blute, Mary-Rita</creator><creator>Hebel, J. Richard</creator><creator>Carson, Jeffrey L.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope></search><sort><creationdate>201308</creationdate><title>Delirium Outcomes in a Randomized Trial of Blood Transfusion Thresholds in Hospitalized Older Adults with Hip Fracture</title><author>Gruber-Baldini, Ann L. ; Marcantonio, Edward ; Orwig, Denise ; Magaziner, Jay ; Terrin, Michael ; Barr, Erik ; Brown, Jessica P. ; Paris, Barbara ; Zagorin, Aleksandra ; Roffey, Darren M. ; Zakriya, Khwaja ; Blute, Mary-Rita ; Hebel, J. Richard ; Carson, Jeffrey L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4896-ab7acc93aeeaba14e51f8620b4a47d3405fd9962424984772b28f19425085dcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>blood transfusion</topic><topic>Blood Transfusion - methods</topic><topic>Blood transfusions</topic><topic>Clinical outcomes</topic><topic>Delirium</topic><topic>Delirium - blood</topic><topic>Delirium - diagnosis</topic><topic>Delirium - prevention & control</topic><topic>Erythrocyte Transfusion - methods</topic><topic>Female</topic><topic>Fractures</topic><topic>General aspects</topic><topic>Hemoglobinometry</topic><topic>hip fracture</topic><topic>Hip Fractures - blood</topic><topic>Hip Fractures - surgery</topic><topic>Hip joint</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental Status Schedule</topic><topic>Miscellaneous</topic><topic>Neuropsychological Tests</topic><topic>Older people</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gruber-Baldini, Ann L.</creatorcontrib><creatorcontrib>Marcantonio, Edward</creatorcontrib><creatorcontrib>Orwig, Denise</creatorcontrib><creatorcontrib>Magaziner, Jay</creatorcontrib><creatorcontrib>Terrin, Michael</creatorcontrib><creatorcontrib>Barr, Erik</creatorcontrib><creatorcontrib>Brown, Jessica P.</creatorcontrib><creatorcontrib>Paris, Barbara</creatorcontrib><creatorcontrib>Zagorin, Aleksandra</creatorcontrib><creatorcontrib>Roffey, Darren M.</creatorcontrib><creatorcontrib>Zakriya, Khwaja</creatorcontrib><creatorcontrib>Blute, Mary-Rita</creatorcontrib><creatorcontrib>Hebel, J. Richard</creatorcontrib><creatorcontrib>Carson, Jeffrey L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gruber-Baldini, Ann L.</au><au>Marcantonio, Edward</au><au>Orwig, Denise</au><au>Magaziner, Jay</au><au>Terrin, Michael</au><au>Barr, Erik</au><au>Brown, Jessica P.</au><au>Paris, Barbara</au><au>Zagorin, Aleksandra</au><au>Roffey, Darren M.</au><au>Zakriya, Khwaja</au><au>Blute, Mary-Rita</au><au>Hebel, J. Richard</au><au>Carson, Jeffrey L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delirium Outcomes in a Randomized Trial of Blood Transfusion Thresholds in Hospitalized Older Adults with Hip Fracture</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2013-08</date><risdate>2013</risdate><volume>61</volume><issue>8</issue><spage>1286</spage><epage>1295</epage><pages>1286-1295</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><abstract>Objectives
To determine whether a higher blood transfusion threshold would prevent new or worsening delirium symptoms in the hospital after hip fracture surgery.
Design
Ancillary study to a randomized clinical trial.
Setting
Thirteen hospitals in the United States and Canada.
Participants
One hundred thirty‐nine individuals hospitalized with hip fracture aged 50 and older (mean age 81.5 ± 9.1) with cardiovascular disease or risk factors and hemoglobin concentrations of less than 10 g/dL within 3 days of surgery recruited in an ancillary study of the Transfusion Trigger Trial for Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair.
Intervention
Individuals in the liberal treatment group received one unit of packed red blood cells and as much blood as needed to maintain hemoglobin concentrations at greater than 10 g/dL; those in the restrictive treatment group received transfusions if they developed symptoms of anemia or their hemoglobin fell below 8 g/dL.
Measurements
Delirium assessments were performed before randomization and up to three times after randomization. The primary outcome was severity of delirium according to the Memorial Delirium Assessment Scale (MDAS). The secondary outcome was the presence or absence of delirium defined according to the Confusion Assessment Method (CAM).
Results
The liberal group received a median two units of blood and the restrictive group zero units of blood. Hemoglobin concentration on Day 1 after randomization was 1.4 g/dL higher in the liberal group. Treatment groups did not differ significantly at any time point or over time on MDAS delirium severity (P = .28) or CAM delirium presence (P = .83).
Conclusion
Blood transfusion to maintain hemoglobin concentrations greater than 10 g/dL alone is unlikely to influence delirium severity or rate in individuals with hip fracture after surgery with a hemoglobin concentration less than 10 g/dL.</abstract><cop>Hoboken, NJ</cop><pub>Blackwell Publishing Ltd</pub><pmid>23898894</pmid><doi>10.1111/jgs.12396</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-8614 |
| ispartof | Journal of the American Geriatrics Society (JAGS), 2013-08, Vol.61 (8), p.1286-1295 |
| issn | 0002-8614 1532-5415 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult and adolescent clinical studies Aged Aged, 80 and over Biological and medical sciences blood transfusion Blood Transfusion - methods Blood transfusions Clinical outcomes Delirium Delirium - blood Delirium - diagnosis Delirium - prevention & control Erythrocyte Transfusion - methods Female Fractures General aspects Hemoglobinometry hip fracture Hip Fractures - blood Hip Fractures - surgery Hip joint Hospitalization Humans Male Medical sciences Mental Status Schedule Miscellaneous Neuropsychological Tests Older people Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors |
| title | Delirium Outcomes in a Randomized Trial of Blood Transfusion Thresholds in Hospitalized Older Adults with Hip Fracture |
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