Studies on the up regulation of alpha-adrenoceptors on rat hippocampal perikarya by chemical lesion of the median raphe nucleus

Neurotoxin-induced lesion of the serotonergic raphe-hippocampal pathway produced about a 50% increase in the density of a nM affinity alpha-adrenergic binding site for ( 3H)WB-4101 in rat hippocampus 18 days postlesion without altering the specific binding of ( 3H)5-HT to serotonergic receptors. The...

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Veröffentlicht in:	Life sciences (1973) 1985-08, Vol.37 (5), p.449-460
Hauptverfasser:	Consolo, S., Wang, J-X., Forloni, G.L., Mocchetti, I., Racagni, G., Ladinsky, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Membrane - analysis Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Dioxanes - metabolism Female Fundamental and applied biological sciences. Psychology Hippocampus - analysis Kainic Acid - pharmacology Neurotoxins - pharmacology Norepinephrine - metabolism Raphe Nuclei - drug effects Raphe Nuclei - metabolism Raphe Nuclei - physiology Rats Receptors, Adrenergic, alpha - analysis Receptors, Serotonin - metabolism Serotonin - metabolism Vertebrates: nervous system and sense organs
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