A highly efficient one-flask method for the preparation of the individual diastereoisomers of ribonucleoside 3',5'-cycle N-substituted phosphoramidates via the direct Appel reaction. X-ray structure of trans-5-isopropyl-2'-deoxyuridine 3'5'-cyclic N-benzylphosphoramidate

A superior method for the preparation of 3',5'-cyclic N-substituted phosphoramidates of purine and pyrimidine ribo- and deoxyribonucleosides is reported. An Appel-type reaction of various 3',5'-cyclic nucleoside monophosphates using a Ph sub(3)P/CCl sub(4) pretreatment followed b...

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Veröffentlicht in:	Journal of organic chemistry 1985-01, Vol.50 (8), p.1271-1278
Hauptverfasser:	Beres, J, Bentrude, W G, Parkanji, L, Kalman, A, Sopchik, A E
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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