A CASE-CONTROL STUDY OF DEMENTIA OF THE ALZHEIMER TYPE
A case-control study to assess factors of possible etiologic significance to dementia of the Alzheimer type was conducted with 78 male cases diagnosed in 1979–1982 at the Veterans Administration Medical Center in Minneapolis, Minnesota and age-race-sex-matched hospital and neighborhood controls (14...
Gespeichert in:
| Veröffentlicht in: | American journal of epidemiology 1985-03, Vol.121 (3), p.414-421 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 421 |
|---|---|
| container_issue | 3 |
| container_start_page | 414 |
| container_title | American journal of epidemiology |
| container_volume | 121 |
| creator | FRENCH, L. RONALD SCHUMAN, LEONARD M. MORTIMER, JAMES A. HUTTON, J. THOMAS BOATMAN, RUBY A. CHRISTIANS, BONNA |
| description | A case-control study to assess factors of possible etiologic significance to dementia of the Alzheimer type was conducted with 78 male cases diagnosed in 1979–1982 at the Veterans Administration Medical Center in Minneapolis, Minnesota and age-race-sex-matched hospital and neighborhood controls (14 of 16 autopsied cases were histopathologically confirmed). Information was obtained on variables relevant to viral, genetic, and immunologic hypotheses, and on possible occupational and environmental exposures, drug use, pychologic stress, smoking, and alcohol consumption. The only major difference between patients with dementia of the Alzheimer type and controls was a significantly greater occurrence of antecedent head trauma in the patients (odds ratio=4.50). This finding is consistent with the literature on posttraumatic dementia but its importance is presently unclear. |
| doi_str_mv | 10.1093/oxfordjournals.aje.a114013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_14403062</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>14403062</sourcerecordid><originalsourceid>FETCH-LOGICAL-c440t-85b64a3322c14a1976b56e78926439ffa2f3b5925379f5e1248332dade24a6f3</originalsourceid><addsrcrecordid>eNpdkF1LwzAUhoMoOqc_QSgq3nXm5KuNd93s3HA60QrqTci6BDa3VZMN9N-bsTrQqxx4n5P38CB0CrgFWNLL6stWbjytVm6hZ76lp6alARgGuoMawBIRC8LFLmpgjEksiSAH6ND7KcYAkuN9tB9YBhQaSGRRJ3vK487wvngcDqKn4vn6NRp2o-v8Lr8v-tl6Lnp5lA3eenn_Ln-MiteH_Ajt2VBtjuu3iYpuXnR68WB40-9kg7hkDC_jlI8E05QSUgLTIBMx4sIkaTiJUWmtJpaOuCScJtJyA4SlAR7rsSFMC0ub6GLz7YerPlfGL9V84kszm-mFqVZeQWihWJAAnv0Df-0oCIBgPAUaqKsNVbrKe2es-nCTuXbfCrBam1V_zapgVtVmw_JJXbEazc14u1qrDPl5nWtf6pl1elFO_BaT4QpKcMDiDTbxS_O1jbV7VyKhCVe9lzeVyuTlpn3bVW36A6oXjpU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1306645813</pqid></control><display><type>article</type><title>A CASE-CONTROL STUDY OF DEMENTIA OF THE ALZHEIMER TYPE</title><source>MEDLINE</source><source>Oxford University Press Journals Digital Archive Legacy</source><source>Periodicals Index Online</source><creator>FRENCH, L. RONALD ; SCHUMAN, LEONARD M. ; MORTIMER, JAMES A. ; HUTTON, J. THOMAS ; BOATMAN, RUBY A. ; CHRISTIANS, BONNA</creator><creatorcontrib>FRENCH, L. RONALD ; SCHUMAN, LEONARD M. ; MORTIMER, JAMES A. ; HUTTON, J. THOMAS ; BOATMAN, RUBY A. ; CHRISTIANS, BONNA</creatorcontrib><description>A case-control study to assess factors of possible etiologic significance to dementia of the Alzheimer type was conducted with 78 male cases diagnosed in 1979–1982 at the Veterans Administration Medical Center in Minneapolis, Minnesota and age-race-sex-matched hospital and neighborhood controls (14 of 16 autopsied cases were histopathologically confirmed). Information was obtained on variables relevant to viral, genetic, and immunologic hypotheses, and on possible occupational and environmental exposures, drug use, pychologic stress, smoking, and alcohol consumption. The only major difference between patients with dementia of the Alzheimer type and controls was a significantly greater occurrence of antecedent head trauma in the patients (odds ratio=4.50). This finding is consistent with the literature on posttraumatic dementia but its importance is presently unclear.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/oxfordjournals.aje.a114013</identifier><identifier>PMID: 4014131</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Aged ; Aging ; Alzheimer Disease - diagnosis ; Alzheimer Disease - epidemiology ; Alzheimer Disease - etiology ; Alzheimer's disease ; Biological and medical sciences ; Craniocerebral Trauma - complications ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; dementia ; Educational Status ; Environmental Exposure ; Epidemiologic Methods ; Humans ; Male ; Medical sciences ; Middle Aged ; Minnesota ; Neurology ; presenile ; senile</subject><ispartof>American journal of epidemiology, 1985-03, Vol.121 (3), p.414-421</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-85b64a3322c14a1976b56e78926439ffa2f3b5925379f5e1248332dade24a6f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27852,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9066320$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4014131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FRENCH, L. RONALD</creatorcontrib><creatorcontrib>SCHUMAN, LEONARD M.</creatorcontrib><creatorcontrib>MORTIMER, JAMES A.</creatorcontrib><creatorcontrib>HUTTON, J. THOMAS</creatorcontrib><creatorcontrib>BOATMAN, RUBY A.</creatorcontrib><creatorcontrib>CHRISTIANS, BONNA</creatorcontrib><title>A CASE-CONTROL STUDY OF DEMENTIA OF THE ALZHEIMER TYPE</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>A case-control study to assess factors of possible etiologic significance to dementia of the Alzheimer type was conducted with 78 male cases diagnosed in 1979–1982 at the Veterans Administration Medical Center in Minneapolis, Minnesota and age-race-sex-matched hospital and neighborhood controls (14 of 16 autopsied cases were histopathologically confirmed). Information was obtained on variables relevant to viral, genetic, and immunologic hypotheses, and on possible occupational and environmental exposures, drug use, pychologic stress, smoking, and alcohol consumption. The only major difference between patients with dementia of the Alzheimer type and controls was a significantly greater occurrence of antecedent head trauma in the patients (odds ratio=4.50). This finding is consistent with the literature on posttraumatic dementia but its importance is presently unclear.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - epidemiology</subject><subject>Alzheimer Disease - etiology</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>Craniocerebral Trauma - complications</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>dementia</subject><subject>Educational Status</subject><subject>Environmental Exposure</subject><subject>Epidemiologic Methods</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Minnesota</subject><subject>Neurology</subject><subject>presenile</subject><subject>senile</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNpdkF1LwzAUhoMoOqc_QSgq3nXm5KuNd93s3HA60QrqTci6BDa3VZMN9N-bsTrQqxx4n5P38CB0CrgFWNLL6stWbjytVm6hZ76lp6alARgGuoMawBIRC8LFLmpgjEksiSAH6ND7KcYAkuN9tB9YBhQaSGRRJ3vK487wvngcDqKn4vn6NRp2o-v8Lr8v-tl6Lnp5lA3eenn_Ln-MiteH_Ajt2VBtjuu3iYpuXnR68WB40-9kg7hkDC_jlI8E05QSUgLTIBMx4sIkaTiJUWmtJpaOuCScJtJyA4SlAR7rsSFMC0ub6GLz7YerPlfGL9V84kszm-mFqVZeQWihWJAAnv0Df-0oCIBgPAUaqKsNVbrKe2es-nCTuXbfCrBam1V_zapgVtVmw_JJXbEazc14u1qrDPl5nWtf6pl1elFO_BaT4QpKcMDiDTbxS_O1jbV7VyKhCVe9lzeVyuTlpn3bVW36A6oXjpU</recordid><startdate>198503</startdate><enddate>198503</enddate><creator>FRENCH, L. RONALD</creator><creator>SCHUMAN, LEONARD M.</creator><creator>MORTIMER, JAMES A.</creator><creator>HUTTON, J. THOMAS</creator><creator>BOATMAN, RUBY A.</creator><creator>CHRISTIANS, BONNA</creator><general>Oxford University Press</general><general>School of Hygiene and Public Health of the Johns Hopkins University</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HVZBN</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>198503</creationdate><title>A CASE-CONTROL STUDY OF DEMENTIA OF THE ALZHEIMER TYPE</title><author>FRENCH, L. RONALD ; SCHUMAN, LEONARD M. ; MORTIMER, JAMES A. ; HUTTON, J. THOMAS ; BOATMAN, RUBY A. ; CHRISTIANS, BONNA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-85b64a3322c14a1976b56e78926439ffa2f3b5925379f5e1248332dade24a6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - epidemiology</topic><topic>Alzheimer Disease - etiology</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>Craniocerebral Trauma - complications</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>dementia</topic><topic>Educational Status</topic><topic>Environmental Exposure</topic><topic>Epidemiologic Methods</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Minnesota</topic><topic>Neurology</topic><topic>presenile</topic><topic>senile</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FRENCH, L. RONALD</creatorcontrib><creatorcontrib>SCHUMAN, LEONARD M.</creatorcontrib><creatorcontrib>MORTIMER, JAMES A.</creatorcontrib><creatorcontrib>HUTTON, J. THOMAS</creatorcontrib><creatorcontrib>BOATMAN, RUBY A.</creatorcontrib><creatorcontrib>CHRISTIANS, BONNA</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Periodicals Index Online Segment 24</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - West</collection><collection>Primary Sources Access (Plan D) - International</collection><collection>Primary Sources Access & Build (Plan A) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Midwest</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Northeast</collection><collection>Primary Sources Access (Plan D) - Southeast</collection><collection>Primary Sources Access (Plan D) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Southeast</collection><collection>Primary Sources Access (Plan D) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - UK / I</collection><collection>Primary Sources Access (Plan D) - Canada</collection><collection>Primary Sources Access (Plan D) - EMEALA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - International</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - International</collection><collection>Primary Sources Access (Plan D) - West</collection><collection>Periodicals Index Online Segments 1-50</collection><collection>Primary Sources Access (Plan D) - APAC</collection><collection>Primary Sources Access (Plan D) - Midwest</collection><collection>Primary Sources Access (Plan D) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Canada</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - EMEALA</collection><collection>Primary Sources Access & Build (Plan A) - APAC</collection><collection>Primary Sources Access & Build (Plan A) - Canada</collection><collection>Primary Sources Access & Build (Plan A) - West</collection><collection>Primary Sources Access & Build (Plan A) - EMEALA</collection><collection>Primary Sources Access (Plan D) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - Midwest</collection><collection>Primary Sources Access & Build (Plan A) - North Central</collection><collection>Primary Sources Access & Build (Plan A) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - Southeast</collection><collection>Primary Sources Access (Plan D) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - APAC</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - MEA</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FRENCH, L. RONALD</au><au>SCHUMAN, LEONARD M.</au><au>MORTIMER, JAMES A.</au><au>HUTTON, J. THOMAS</au><au>BOATMAN, RUBY A.</au><au>CHRISTIANS, BONNA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A CASE-CONTROL STUDY OF DEMENTIA OF THE ALZHEIMER TYPE</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>1985-03</date><risdate>1985</risdate><volume>121</volume><issue>3</issue><spage>414</spage><epage>421</epage><pages>414-421</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>A case-control study to assess factors of possible etiologic significance to dementia of the Alzheimer type was conducted with 78 male cases diagnosed in 1979–1982 at the Veterans Administration Medical Center in Minneapolis, Minnesota and age-race-sex-matched hospital and neighborhood controls (14 of 16 autopsied cases were histopathologically confirmed). Information was obtained on variables relevant to viral, genetic, and immunologic hypotheses, and on possible occupational and environmental exposures, drug use, pychologic stress, smoking, and alcohol consumption. The only major difference between patients with dementia of the Alzheimer type and controls was a significantly greater occurrence of antecedent head trauma in the patients (odds ratio=4.50). This finding is consistent with the literature on posttraumatic dementia but its importance is presently unclear.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>4014131</pmid><doi>10.1093/oxfordjournals.aje.a114013</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9262 |
| ispartof | American journal of epidemiology, 1985-03, Vol.121 (3), p.414-421 |
| issn | 0002-9262 1476-6256 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14403062 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; Periodicals Index Online |
| subjects | Adult Aged Aging Alzheimer Disease - diagnosis Alzheimer Disease - epidemiology Alzheimer Disease - etiology Alzheimer's disease Biological and medical sciences Craniocerebral Trauma - complications Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases dementia Educational Status Environmental Exposure Epidemiologic Methods Humans Male Medical sciences Middle Aged Minnesota Neurology presenile senile |
| title | A CASE-CONTROL STUDY OF DEMENTIA OF THE ALZHEIMER TYPE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T04%3A09%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20CASE-CONTROL%20STUDY%20OF%20DEMENTIA%20OF%20THE%20ALZHEIMER%20TYPE&rft.jtitle=American%20journal%20of%20epidemiology&rft.au=FRENCH,%20L.%20RONALD&rft.date=1985-03&rft.volume=121&rft.issue=3&rft.spage=414&rft.epage=421&rft.pages=414-421&rft.issn=0002-9262&rft.eissn=1476-6256&rft.coden=AJEPAS&rft_id=info:doi/10.1093/oxfordjournals.aje.a114013&rft_dat=%3Cproquest_cross%3E14403062%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1306645813&rft_id=info:pmid/4014131&rfr_iscdi=true |