CE-MS for metabolomics: Developments and applications in the period 2010-2012
CE‐MS has emerged as a powerful technique for the profiling of (highly) polar and charged metabolites in biological samples. This review provides an update of the most recent developments in CE‐MS for metabolomics covering the scientific literature from July 2010 to June 2012. The present paper is a...
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| Veröffentlicht in: | Electrophoresis 2013-01, Vol.34 (1), p.86-98 |
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| creator | Ramautar, Rawi Somsen, Govert W. de Jong, Gerhardus J. |
| description | CE‐MS has emerged as a powerful technique for the profiling of (highly) polar and charged metabolites in biological samples. This review provides an update of the most recent developments in CE‐MS for metabolomics covering the scientific literature from July 2010 to June 2012. The present paper is an update of two previous review papers covering the years 2000–2010 (Electrophoresis 2009, 30, 276–291; Electrophoresis 2011, 32, 52–65). Emerging technological developments used in CE‐MS for metabolomics are discussed, such as the use of novel interfacing techniques for coupling CE to MS. Representative examples illustrate the applicability of CE‐MS in the fields of biomedical, clinical, microbial, plant, environmental and food metabolomics. Concerning targeted and non‐targeted approaches, a comprehensive overview of recent CE‐MS‐based metabolomics studies is given in a table. Information on sample type and pretreatment, capillary coatings and MS detection mode is provided. Finally, general conclusions and perspectives are provided. |
| doi_str_mv | 10.1002/elps.201200390 |
| format | Article |
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Finally, general conclusions and perspectives are provided.</description><subject>Animals</subject><subject>Biomedical and clinical</subject><subject>Charging</subject><subject>Clinical Chemistry Tests - methods</subject><subject>Coatings</subject><subject>Covering</subject><subject>Electrophoresis</subject><subject>Electrophoresis, Capillary - methods</subject><subject>Electrophoresis, Capillary - trends</subject><subject>Environmental and food</subject><subject>Foods</subject><subject>Humans</subject><subject>Mass Spectrometry - methods</subject><subject>Mass Spectrometry - trends</subject><subject>Metabolomics</subject><subject>Metabolomics - trends</subject><subject>Microbial and plant</subject><subject>Microorganisms</subject><subject>Plants - chemistry</subject><subject>Profiling</subject><subject>Solid Phase Extraction - methods</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>Spectrometry, Mass, Electrospray Ionization - trends</subject><subject>Tables (data)</subject><subject>Technological developments</subject><issn>0173-0835</issn><issn>1522-2683</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1v0zAYh60JtHWDK0fkI5eU198uN9S1BaljkwYCcbHs5I0wJHEWpxv770nV0etOvjzP77UeQt4wmDMA_h6bPs85MA4gFnBCZkxxXnBtxQsyA2ZEAVaoM3Ke828AkAspT8kZF0wzBnpGrpar4uqW1mmgLY4-pCa1scwf6CXeY5P6FrsxU99V1Pd9E0s_xtRlGjs6_kLa4xBTRaf7UOw_8Yq8rH2T8fXTe0G-rVdfl5-K7fXm8_LjtigVM6qQtQcIoeJolUasAwijqtJykNZwzlQI3tRCGsaCFjp4C9ybhZe8Al1Wpbgg7w67_ZDudphH18ZcYtP4DtMuOybFwhjQU4ZnUW4EV9JaPaHzA1oOKecBa9cPsfXDo2Pg9rXdvrY71p6Et0_bu9BidcT_550AeQAeYoOPz8y51fbmVkqjJq04aDGP-Peo-eGP02ZK5b5_2bi1Empjf_5wa_EPsFCW2w</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Ramautar, Rawi</creator><creator>Somsen, Govert W.</creator><creator>de Jong, Gerhardus J.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>201301</creationdate><title>CE-MS for metabolomics: Developments and applications in the period 2010-2012</title><author>Ramautar, Rawi ; 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biomedical and clinical Charging Clinical Chemistry Tests - methods Coatings Covering Electrophoresis Electrophoresis, Capillary - methods Electrophoresis, Capillary - trends Environmental and food Foods Humans Mass Spectrometry - methods Mass Spectrometry - trends Metabolomics Metabolomics - trends Microbial and plant Microorganisms Plants - chemistry Profiling Solid Phase Extraction - methods Spectrometry, Mass, Electrospray Ionization - methods Spectrometry, Mass, Electrospray Ionization - trends Tables (data) Technological developments |
| title | CE-MS for metabolomics: Developments and applications in the period 2010-2012 |
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