Thermal behavior of some antihistamines
Thermogravimetry (TG), differential scanning calorimetry (DSC), polarized light thermal microscopy (PLTM), as well as X-ray powder diffraction (XRD) and Fourier transformed infrared spectroscopy (FTIR) were used to study the thermal behavior and the chemical structure of cimetidine, famotidine, rani...
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| Veröffentlicht in: | Journal of thermal analysis and calorimetry 2013-03, Vol.111 (3), p.2019-2028 |
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| container_title | Journal of thermal analysis and calorimetry |
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| creator | Perpétuo, G. L. Gálico, D. A. Fugita, R. A. Castro, R. A. E. Eusébio, M. E. S. Treu-Filho, O. Silva, A. C. M. Bannach, G. |
| description | Thermogravimetry (TG), differential scanning calorimetry (DSC), polarized light thermal microscopy (PLTM), as well as X-ray powder diffraction (XRD) and Fourier transformed infrared spectroscopy (FTIR) were used to study the thermal behavior and the chemical structure of cimetidine, famotidine, ranitidine-HCl, and nizatidine. The TG–DSC curves show that the famotidine and ranitidine-HCl suffer decomposition during melting and they are thermally less stable in comparison with cimetidine and nizatidine, the latter being the most stable of all the drugs studied in this study. The DSC curves of famotidine and ranitidine-HCl show exothermic peaks immediately after the melting, confirming the occurrence of thermal decomposition. The DSC curves also show that the cimetidine and nizatidine have some thermal stability after melting. The thermal events shown in the PLTM images are consistent with the results shown in the TG–DSC and DSC curves. The XRD patterns show that the cimetidine and famotidine are less crystalline compared with ranitidine-HCl and nizatidine. The theoretical FTIR bands are in agreement with those obtained experimentally, and in some cases, no difference is observed between the theoretical and experimental values, even being identical in one of the cases. |
| doi_str_mv | 10.1007/s10973-012-2247-0 |
| format | Article |
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L. ; Gálico, D. A. ; Fugita, R. A. ; Castro, R. A. E. ; Eusébio, M. E. S. ; Treu-Filho, O. ; Silva, A. C. M. ; Bannach, G.</creator><creatorcontrib>Perpétuo, G. L. ; Gálico, D. A. ; Fugita, R. A. ; Castro, R. A. E. ; Eusébio, M. E. S. ; Treu-Filho, O. ; Silva, A. C. M. ; Bannach, G.</creatorcontrib><description>Thermogravimetry (TG), differential scanning calorimetry (DSC), polarized light thermal microscopy (PLTM), as well as X-ray powder diffraction (XRD) and Fourier transformed infrared spectroscopy (FTIR) were used to study the thermal behavior and the chemical structure of cimetidine, famotidine, ranitidine-HCl, and nizatidine. The TG–DSC curves show that the famotidine and ranitidine-HCl suffer decomposition during melting and they are thermally less stable in comparison with cimetidine and nizatidine, the latter being the most stable of all the drugs studied in this study. The DSC curves of famotidine and ranitidine-HCl show exothermic peaks immediately after the melting, confirming the occurrence of thermal decomposition. The DSC curves also show that the cimetidine and nizatidine have some thermal stability after melting. The thermal events shown in the PLTM images are consistent with the results shown in the TG–DSC and DSC curves. The XRD patterns show that the cimetidine and famotidine are less crystalline compared with ranitidine-HCl and nizatidine. The theoretical FTIR bands are in agreement with those obtained experimentally, and in some cases, no difference is observed between the theoretical and experimental values, even being identical in one of the cases.</description><identifier>ISSN: 1388-6150</identifier><identifier>EISSN: 1588-2926</identifier><identifier>EISSN: 1572-8943</identifier><identifier>DOI: 10.1007/s10973-012-2247-0</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Analysis ; Analytical Chemistry ; Antihistamines ; Antiulcer drugs ; Biological and medical sciences ; Calorimetry ; Chemistry ; Chemistry and Materials Science ; Cimetidine ; Differential scanning calorimetry ; Diffraction ; Digestive system ; Drugs ; Histamine and antagonists. Allergy ; Infrared spectroscopy ; Inorganic Chemistry ; Measurement Science and Instrumentation ; Medical sciences ; Melting ; Pharmacology. Drug treatments ; Physical Chemistry ; Polymer Sciences ; Thermal analysis ; Thermal decomposition ; X-rays</subject><ispartof>Journal of thermal analysis and calorimetry, 2013-03, Vol.111 (3), p.2019-2028</ispartof><rights>Akadémiai Kiadó, Budapest, Hungary 2012</rights><rights>2014 INIST-CNRS</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-5fb91b5bd30cbc239c8824cfee93125f3b34481dc35e47d580155c64b292eae43</citedby><cites>FETCH-LOGICAL-c424t-5fb91b5bd30cbc239c8824cfee93125f3b34481dc35e47d580155c64b292eae43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10973-012-2247-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10973-012-2247-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27643419$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Perpétuo, G. L.</creatorcontrib><creatorcontrib>Gálico, D. A.</creatorcontrib><creatorcontrib>Fugita, R. A.</creatorcontrib><creatorcontrib>Castro, R. A. E.</creatorcontrib><creatorcontrib>Eusébio, M. E. S.</creatorcontrib><creatorcontrib>Treu-Filho, O.</creatorcontrib><creatorcontrib>Silva, A. C. M.</creatorcontrib><creatorcontrib>Bannach, G.</creatorcontrib><title>Thermal behavior of some antihistamines</title><title>Journal of thermal analysis and calorimetry</title><addtitle>J Therm Anal Calorim</addtitle><description>Thermogravimetry (TG), differential scanning calorimetry (DSC), polarized light thermal microscopy (PLTM), as well as X-ray powder diffraction (XRD) and Fourier transformed infrared spectroscopy (FTIR) were used to study the thermal behavior and the chemical structure of cimetidine, famotidine, ranitidine-HCl, and nizatidine. The TG–DSC curves show that the famotidine and ranitidine-HCl suffer decomposition during melting and they are thermally less stable in comparison with cimetidine and nizatidine, the latter being the most stable of all the drugs studied in this study. The DSC curves of famotidine and ranitidine-HCl show exothermic peaks immediately after the melting, confirming the occurrence of thermal decomposition. The DSC curves also show that the cimetidine and nizatidine have some thermal stability after melting. The thermal events shown in the PLTM images are consistent with the results shown in the TG–DSC and DSC curves. The XRD patterns show that the cimetidine and famotidine are less crystalline compared with ranitidine-HCl and nizatidine. The theoretical FTIR bands are in agreement with those obtained experimentally, and in some cases, no difference is observed between the theoretical and experimental values, even being identical in one of the cases.</description><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Antihistamines</subject><subject>Antiulcer drugs</subject><subject>Biological and medical sciences</subject><subject>Calorimetry</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Cimetidine</subject><subject>Differential scanning calorimetry</subject><subject>Diffraction</subject><subject>Digestive system</subject><subject>Drugs</subject><subject>Histamine and antagonists. Allergy</subject><subject>Infrared spectroscopy</subject><subject>Inorganic Chemistry</subject><subject>Measurement Science and Instrumentation</subject><subject>Medical sciences</subject><subject>Melting</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Thermal analysis</subject><subject>Thermal decomposition</subject><subject>X-rays</subject><issn>1388-6150</issn><issn>1588-2926</issn><issn>1572-8943</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhosoKKs_wNteRD10zWfbHGXxCwTBj3NI08lupG0004r-e1MqgheZwwzJ8w7Dk2XHlKwoIeUFUqJKnhPKcsZEmZOd7IDKqsqZYsVumnmaCyrJfnaE6GvCKCmUrNRBdvq8hdiZdlnD1nz4EJfBLTF0sDT94LceB9P5HvAw23OmRTj66Yvs5frqeX2b3z_c3K0v73MrmBhy6WpFa1k3nNjaMq5sVTFhHYDilEnHay5ERRvLJYiykRWhUtpC1OlSMCD4Ijub977F8D4CDrrzaKFtTQ9hRE0FV6XkRUkSuprRjWlB-96FIRqbqoHO29CD8-n9kvNCVKpgU-D8TyAxA3wOGzMi6runx78snVkbA2IEp9-i70z80pToSbqepeskXU_S9ZQ5-bndoDWti6a3Hn-DrCwEF1Qljs0cpq9-A1G_hjH2Ses_y78BWUOOWA</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Perpétuo, G. L.</creator><creator>Gálico, D. A.</creator><creator>Fugita, R. A.</creator><creator>Castro, R. A. E.</creator><creator>Eusébio, M. E. S.</creator><creator>Treu-Filho, O.</creator><creator>Silva, A. C. M.</creator><creator>Bannach, G.</creator><general>Springer Netherlands</general><general>Springer</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20130301</creationdate><title>Thermal behavior of some antihistamines</title><author>Perpétuo, G. L. ; Gálico, D. A. ; Fugita, R. A. ; Castro, R. A. E. ; Eusébio, M. E. S. ; Treu-Filho, O. ; Silva, A. C. M. ; Bannach, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-5fb91b5bd30cbc239c8824cfee93125f3b34481dc35e47d580155c64b292eae43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Analysis</topic><topic>Analytical Chemistry</topic><topic>Antihistamines</topic><topic>Antiulcer drugs</topic><topic>Biological and medical sciences</topic><topic>Calorimetry</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Cimetidine</topic><topic>Differential scanning calorimetry</topic><topic>Diffraction</topic><topic>Digestive system</topic><topic>Drugs</topic><topic>Histamine and antagonists. Allergy</topic><topic>Infrared spectroscopy</topic><topic>Inorganic Chemistry</topic><topic>Measurement Science and Instrumentation</topic><topic>Medical sciences</topic><topic>Melting</topic><topic>Pharmacology. Drug treatments</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Thermal analysis</topic><topic>Thermal decomposition</topic><topic>X-rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perpétuo, G. L.</creatorcontrib><creatorcontrib>Gálico, D. A.</creatorcontrib><creatorcontrib>Fugita, R. A.</creatorcontrib><creatorcontrib>Castro, R. A. E.</creatorcontrib><creatorcontrib>Eusébio, M. E. S.</creatorcontrib><creatorcontrib>Treu-Filho, O.</creatorcontrib><creatorcontrib>Silva, A. C. 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M.</au><au>Bannach, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thermal behavior of some antihistamines</atitle><jtitle>Journal of thermal analysis and calorimetry</jtitle><stitle>J Therm Anal Calorim</stitle><date>2013-03-01</date><risdate>2013</risdate><volume>111</volume><issue>3</issue><spage>2019</spage><epage>2028</epage><pages>2019-2028</pages><issn>1388-6150</issn><eissn>1588-2926</eissn><eissn>1572-8943</eissn><abstract>Thermogravimetry (TG), differential scanning calorimetry (DSC), polarized light thermal microscopy (PLTM), as well as X-ray powder diffraction (XRD) and Fourier transformed infrared spectroscopy (FTIR) were used to study the thermal behavior and the chemical structure of cimetidine, famotidine, ranitidine-HCl, and nizatidine. The TG–DSC curves show that the famotidine and ranitidine-HCl suffer decomposition during melting and they are thermally less stable in comparison with cimetidine and nizatidine, the latter being the most stable of all the drugs studied in this study. The DSC curves of famotidine and ranitidine-HCl show exothermic peaks immediately after the melting, confirming the occurrence of thermal decomposition. The DSC curves also show that the cimetidine and nizatidine have some thermal stability after melting. The thermal events shown in the PLTM images are consistent with the results shown in the TG–DSC and DSC curves. The XRD patterns show that the cimetidine and famotidine are less crystalline compared with ranitidine-HCl and nizatidine. The theoretical FTIR bands are in agreement with those obtained experimentally, and in some cases, no difference is observed between the theoretical and experimental values, even being identical in one of the cases.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s10973-012-2247-0</doi><tpages>10</tpages></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Analysis Analytical Chemistry Antihistamines Antiulcer drugs Biological and medical sciences Calorimetry Chemistry Chemistry and Materials Science Cimetidine Differential scanning calorimetry Diffraction Digestive system Drugs Histamine and antagonists. Allergy Infrared spectroscopy Inorganic Chemistry Measurement Science and Instrumentation Medical sciences Melting Pharmacology. Drug treatments Physical Chemistry Polymer Sciences Thermal analysis Thermal decomposition X-rays |
| title | Thermal behavior of some antihistamines |
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