High-resolution isotope-dilution mass spectrometry using metabolism of isotope-labeled compounds: Application to drug metabolites

RATIONALE Herein we describe a generic quantitative method using high‐resolution, isotope‐dilution (HRID) metabolism of isotope‐labeled compounds and apply it to the analysis of drug metabolites (DMs) in human plasma. Metabolites (drug) in Safety Testing (MIST) application was one goal. METHODS Test...

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Veröffentlicht in:	Rapid communications in mass spectrometry 2012-11, Vol.26 (22), p.2569-2576
Hauptverfasser:	Vrbanac, J. James, Hilgers, Allen, Dubnicka, Tyson, Shilliday, F. Barclay, Humphries, David, Hayes, Roger N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography Diclofenac - analysis Diclofenac - blood Diclofenac - chemistry Diclofenac - metabolism Dilution Drugs Human Humans Isotope Labeling - methods Isotopes - analysis Isotopes - chemistry Isotopes - metabolism Mass spectrometry Mass Spectrometry - methods Metabolism Metabolites Microsomes, Liver - metabolism Models, Chemical Models, Molecular Parents Pharmaceutical Preparations - analysis Pharmaceutical Preparations - blood Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism Random access memory Sensitivity and Specificity Testosterone - analysis Testosterone - blood Testosterone - chemistry Testosterone - metabolism
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