The use of short-echo-time super(1)H MRS for childhood cerebellar tumours prior to histopathological diagnosis
Background: Proton magnetic resonance spectroscopy (MRS) measures concentrations of metabolites in vivo and provides a powerful method for identifying tumours. MRS has not entered routine clinical use partly due to the difficulty of analysing the spectra. Objective: To create a straightforward metho...
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| Veröffentlicht in: | Pediatric radiology 2007-11, Vol.37 (11), p.1101-1109 |
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| container_title | Pediatric radiology |
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| creator | Harris, Lisa M Davies, Nigel MacPherson, Lesley Foster, Katharine Lateef, Shaheen Natarajan, Kal Sgouros, Spyridon Brundler, Marie-Anne Arvanitis, Theodoros N Grundy, Richard G Peet, Andrew C |
| description | Background: Proton magnetic resonance spectroscopy (MRS) measures concentrations of metabolites in vivo and provides a powerful method for identifying tumours. MRS has not entered routine clinical use partly due to the difficulty of analysing the spectra. Objective: To create a straightforward method for interpreting short-echo-time MRS of childhood cerebellar tumours. Materials and methods: Single-voxel MRS (1.5-T Siemens Symphony NUM4, TR/TE 1,500/30 ms) was performed at presentation in 30 children with cerebellar tumours. The MRS results were analysed for comparison with histological diagnosis. Peak heights for N-acetyl aspartate (NAA), creatine (Cr), choline (Cho) and myo-inositol (mIns) were determined and receiver operator characteristic curves used to select ratios that best discriminated between the tumour types. The method was implemented by a group of clinicians and scientists, blinded to the results. Results: A total of 27 MRS studies met the quality control criteria. NAA/Cr >4.0 distinguished all but one of the astrocytomas from the other tumours. A combination of Cr/Cho |
| doi_str_mv | 10.1007/s00247-007-0571-5 |
| format | Article |
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MRS has not entered routine clinical use partly due to the difficulty of analysing the spectra. Objective: To create a straightforward method for interpreting short-echo-time MRS of childhood cerebellar tumours. Materials and methods: Single-voxel MRS (1.5-T Siemens Symphony NUM4, TR/TE 1,500/30 ms) was performed at presentation in 30 children with cerebellar tumours. The MRS results were analysed for comparison with histological diagnosis. Peak heights for N-acetyl aspartate (NAA), creatine (Cr), choline (Cho) and myo-inositol (mIns) were determined and receiver operator characteristic curves used to select ratios that best discriminated between the tumour types. The method was implemented by a group of clinicians and scientists, blinded to the results. Results: A total of 27 MRS studies met the quality control criteria. NAA/Cr >4.0 distinguished all but one of the astrocytomas from the other tumours. A combination of Cr/Cho <0.75 and mIns/NAA <2.1 separated all the medulloblastomas from the ependymomas. Conclusion: Peak height ratios from short-echo-time MRS can accurately predict the histopathology of childhood cerebellar tumours.</description><identifier>ISSN: 0301-0449</identifier><identifier>EISSN: 1432-1998</identifier><identifier>DOI: 10.1007/s00247-007-0571-5</identifier><language>eng</language><ispartof>Pediatric radiology, 2007-11, Vol.37 (11), p.1101-1109</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Harris, Lisa M</creatorcontrib><creatorcontrib>Davies, Nigel</creatorcontrib><creatorcontrib>MacPherson, Lesley</creatorcontrib><creatorcontrib>Foster, Katharine</creatorcontrib><creatorcontrib>Lateef, Shaheen</creatorcontrib><creatorcontrib>Natarajan, Kal</creatorcontrib><creatorcontrib>Sgouros, Spyridon</creatorcontrib><creatorcontrib>Brundler, Marie-Anne</creatorcontrib><creatorcontrib>Arvanitis, Theodoros N</creatorcontrib><creatorcontrib>Grundy, Richard G</creatorcontrib><creatorcontrib>Peet, Andrew C</creatorcontrib><title>The use of short-echo-time super(1)H MRS for childhood cerebellar tumours prior to histopathological diagnosis</title><title>Pediatric radiology</title><description>Background: Proton magnetic resonance spectroscopy (MRS) measures concentrations of metabolites in vivo and provides a powerful method for identifying tumours. MRS has not entered routine clinical use partly due to the difficulty of analysing the spectra. Objective: To create a straightforward method for interpreting short-echo-time MRS of childhood cerebellar tumours. Materials and methods: Single-voxel MRS (1.5-T Siemens Symphony NUM4, TR/TE 1,500/30 ms) was performed at presentation in 30 children with cerebellar tumours. The MRS results were analysed for comparison with histological diagnosis. Peak heights for N-acetyl aspartate (NAA), creatine (Cr), choline (Cho) and myo-inositol (mIns) were determined and receiver operator characteristic curves used to select ratios that best discriminated between the tumour types. The method was implemented by a group of clinicians and scientists, blinded to the results. Results: A total of 27 MRS studies met the quality control criteria. NAA/Cr >4.0 distinguished all but one of the astrocytomas from the other tumours. A combination of Cr/Cho <0.75 and mIns/NAA <2.1 separated all the medulloblastomas from the ependymomas. Conclusion: Peak height ratios from short-echo-time MRS can accurately predict the histopathology of childhood cerebellar tumours.</description><issn>0301-0449</issn><issn>1432-1998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqVj7tOxDAQRS0EEuHxAXRTLoVhHDvKpkagbWiW7VchmayNnEzw2P_PIvEDVOcWR1c6Sj0YfDKI7bMg1q7V56mxaY1uLlRlnK216brtparQotHoXHetbkS-ENE2xlZqOXiCIgQ8gXhOWdPgWecwE0hZKW3M4w7e9x8wcYLBhzh65hEGSvRJMfYJcpm5JIE1hbOSGXyQzGufPUc-haGPMIb-tLAEuVNXUx-F7v94qzZvr4eXnV4TfxeSfJyDDL-_C3GR4zmhq-3WOmf_of4AlI1UeQ</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Harris, Lisa M</creator><creator>Davies, Nigel</creator><creator>MacPherson, Lesley</creator><creator>Foster, Katharine</creator><creator>Lateef, Shaheen</creator><creator>Natarajan, Kal</creator><creator>Sgouros, Spyridon</creator><creator>Brundler, Marie-Anne</creator><creator>Arvanitis, Theodoros N</creator><creator>Grundy, Richard G</creator><creator>Peet, Andrew C</creator><scope>7TK</scope></search><sort><creationdate>20071101</creationdate><title>The use of short-echo-time super(1)H MRS for childhood cerebellar tumours prior to histopathological diagnosis</title><author>Harris, Lisa M ; Davies, Nigel ; MacPherson, Lesley ; Foster, Katharine ; Lateef, Shaheen ; Natarajan, Kal ; Sgouros, Spyridon ; Brundler, Marie-Anne ; Arvanitis, Theodoros N ; Grundy, Richard G ; Peet, Andrew C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_14392383443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harris, Lisa M</creatorcontrib><creatorcontrib>Davies, Nigel</creatorcontrib><creatorcontrib>MacPherson, Lesley</creatorcontrib><creatorcontrib>Foster, Katharine</creatorcontrib><creatorcontrib>Lateef, Shaheen</creatorcontrib><creatorcontrib>Natarajan, Kal</creatorcontrib><creatorcontrib>Sgouros, Spyridon</creatorcontrib><creatorcontrib>Brundler, Marie-Anne</creatorcontrib><creatorcontrib>Arvanitis, Theodoros N</creatorcontrib><creatorcontrib>Grundy, Richard G</creatorcontrib><creatorcontrib>Peet, Andrew C</creatorcontrib><collection>Neurosciences Abstracts</collection><jtitle>Pediatric radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harris, Lisa M</au><au>Davies, Nigel</au><au>MacPherson, Lesley</au><au>Foster, Katharine</au><au>Lateef, Shaheen</au><au>Natarajan, Kal</au><au>Sgouros, Spyridon</au><au>Brundler, Marie-Anne</au><au>Arvanitis, Theodoros N</au><au>Grundy, Richard G</au><au>Peet, Andrew C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The use of short-echo-time super(1)H MRS for childhood cerebellar tumours prior to histopathological diagnosis</atitle><jtitle>Pediatric radiology</jtitle><date>2007-11-01</date><risdate>2007</risdate><volume>37</volume><issue>11</issue><spage>1101</spage><epage>1109</epage><pages>1101-1109</pages><issn>0301-0449</issn><eissn>1432-1998</eissn><abstract>Background: Proton magnetic resonance spectroscopy (MRS) measures concentrations of metabolites in vivo and provides a powerful method for identifying tumours. MRS has not entered routine clinical use partly due to the difficulty of analysing the spectra. Objective: To create a straightforward method for interpreting short-echo-time MRS of childhood cerebellar tumours. Materials and methods: Single-voxel MRS (1.5-T Siemens Symphony NUM4, TR/TE 1,500/30 ms) was performed at presentation in 30 children with cerebellar tumours. The MRS results were analysed for comparison with histological diagnosis. Peak heights for N-acetyl aspartate (NAA), creatine (Cr), choline (Cho) and myo-inositol (mIns) were determined and receiver operator characteristic curves used to select ratios that best discriminated between the tumour types. The method was implemented by a group of clinicians and scientists, blinded to the results. Results: A total of 27 MRS studies met the quality control criteria. NAA/Cr >4.0 distinguished all but one of the astrocytomas from the other tumours. A combination of Cr/Cho <0.75 and mIns/NAA <2.1 separated all the medulloblastomas from the ependymomas. Conclusion: Peak height ratios from short-echo-time MRS can accurately predict the histopathology of childhood cerebellar tumours.</abstract><doi>10.1007/s00247-007-0571-5</doi></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| title | The use of short-echo-time super(1)H MRS for childhood cerebellar tumours prior to histopathological diagnosis |
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