ADAM10 mediates N-cadherin ectodomain shedding during retinal ganglion cell differentiation in primary cultured retinal cells from the developing chick retina

Here, we examined the role of ADAM10 during retinal cell differentiation in retinal sections and in vitro cultures of developing chick retinal cells from embryonic day 6 (ED6). Immunohistochemistry showed that ADAM10 is abundantly expressed in the inner zone of neuroblastic layer at ED5, and it beco...

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Veröffentlicht in:	Journal of cellular biochemistry 2013-04, Vol.114 (4), p.942-954
Hauptverfasser:	Paudel, Sharada, Kim, Yeoun-Hee, Huh, Man-Il, Kim, Song-Ja, Chang, Yongmin, Park, Young Jeung, Lee, Kyoo Won, Jung, Jae-Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - antagonists & inhibitors ADAM Proteins - genetics ADAM Proteins - metabolism ADAM10 Animals Blotting, Western Cadherins - antagonists & inhibitors Cadherins - genetics Cadherins - metabolism Cell Differentiation Cells Cells, Cultured Chick Embryo Chickens - metabolism Culture Media, Conditioned DIFFERENTIATION Dipeptides - pharmacology Eye Proteins - genetics Eye Proteins - metabolism Gene Expression Regulation Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Hydroxamic Acids - pharmacology Microscopy, Phase-Contrast N-CADHERIN Nerve Tissue Proteins - metabolism Neurites - drug effects Neurites - metabolism Paired Box Transcription Factors - genetics Paired Box Transcription Factors - metabolism Pax6 PAX6 Transcription Factor Primary Cell Culture Protein Structure, Tertiary Protein Transport Repressor Proteins - genetics Repressor Proteins - metabolism Retina Retina - embryology Retina - metabolism Retinal Cone Photoreceptor Cells - drug effects RETINAL DEVELOPMENT RETINAL GANGLION CELL (RGC) Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism
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