Second hematopoietic SCT for leukemia relapsing after myeloablative T cell-depleted transplants does not prolong survival

Patients with leukemia relapsing after allogeneic hematopoietic SCT have a dismal prognosis. A second SCT offers a further opportunity for cure, but has a high rate of treatment failure. To determine the utility of this option, we analyzed 59 consecutive patients relapsing after a myeloablative HLA-...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2013-09, Vol.48 (9), p.1192-1197
Hauptverfasser:	McIver, Z A, Yin, F, Hughes, T, Battiwalla, M, Ito, S, Koklanaris, E, Haggerty, J, Hensel, N F, John Barrett, A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554 631/532/1542 692/699/1541/1990/283 692/700/565/545/576/1955 Adolescent Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Care and treatment Cell Biology Cohort Studies Depletion Failure analysis Female Health aspects Hematologic and hematopoietic diseases Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - immunology Histocompatibility antigen HLA Humans Internal Medicine Leukemia Leukemia - surgery Leukemia - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes Lymphocytes T Male Medical prognosis Medical sciences Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local - pathology original-article Patients Prognosis Public Health Reoperation Stem cell transplantation Stem Cells Survival Survival Rate T cells T-Lymphocytes - cytology T-Lymphocytes - immunology Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation Conditioning - adverse effects Transplantation Conditioning - methods Transplantation, Homologous Transplants Young Adult
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