Lactotransferrin acts as a tumor suppressor in nasopharyngeal carcinoma by repressing AKT through multiple mechanisms

LTF (lactotransferrin, also known as lactoferrin) is a key component of innate immune defense. It has recently been found to have anti-tumor and anti-metastatic activity in different cancers. We previously reported LTF to be the most significantly downregulated gene in nasopharyngeal carcinoma (NPC)...

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Veröffentlicht in:	Oncogene 2013-09, Vol.32 (36), p.4273-4283
Hauptverfasser:	Deng, M, Zhang, W, Tang, H, Ye, Q, Liao, Q, Zhou, Y, Wu, M, Xiong, W, Zheng, Y, Guo, X, Qin, Z, He, W, Zhou, M, Xiang, J, Li, X, Ma, J, Li, G
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 protein 14-3-3 Proteins - metabolism 631/67/581 631/80/86 692/420/755 692/699/67/1536 Adult Aged AKT protein Animals Apoptosis Biomarkers, Tumor - metabolism c-Jun protein Carcinogenesis Carcinoma Care and treatment Cell Biology Cell Line, Tumor Cell Proliferation Cellular signal transduction Exonucleases - metabolism Exoribonucleases Female Gene Expression Head & neck cancer Human Genetics Humans Immune system Immunology Internal Medicine Keratin Kinases Lactoferrin Lactoferrin - genetics Lactoferrin - metabolism Lactoferrins Male MAP kinase Medicine Medicine & Public Health Metastases Mice Middle Aged Mitogen-Activated Protein Kinases - metabolism Nasopharyngeal cancer Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Neoplasm Invasiveness Neoplasm Staging Observations Oncology original-article Properties Protein Binding Protein kinase Protein kinases Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Proto-Oncogene Proteins c-akt - metabolism Signal Transduction Testing Throat cancer Transcription factors Tumor suppressor genes Tumorigenesis
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