Propolis alleviates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced histological changes, oxidative stress and DNA damage in rat liver
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces hepatic damage. Propolis exhibits antioxidant properties and several studies suggest that supplementations with antioxidants can influence hepatotoxicity. Therefore, the aim of the current study was to explore the effectiveness of propolis in allevi...
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| Veröffentlicht in: | Toxicology and industrial health 2013-09, Vol.29 (8), p.677-685 |
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| creator | Türkez, Hasan Geyikoğlu, Fatime Yousef, Mokhtar I Toğar, Basak Vançelik, Serhat |
| description | 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces hepatic damage. Propolis exhibits antioxidant properties and several studies suggest that supplementations with antioxidants can influence hepatotoxicity. Therefore, the aim of the current study was to explore the effectiveness of propolis in alleviating the toxicity of TCDD in the liver of rats. Animals were divided into six groups, namely, TCDD (0.75 and 8 µg/kg body weight (bw)), propolis (50 mg/kg bw), TCDD (0.75 and 8 µg) plus propolis (50 mg/kg bw), and control, respectively. Rats were intraperitoneally administered with their respective doses daily for 21 days. In rats that received a high dose of TCDD, the antioxidant enzymes were significantly decreased and the serious pathological findings were established. Also, the rate of hepatocyte micronucleus (HMN) was increased after treating with TCDD. The reactions of enzymes in control and low-dose group were weak. The frequencies of HMN and liver histology were similar to both the groups. The presence of propolis with TCDD alleviated its pathological effects in hepatic tissue. Propolis also prevented the suppression of antioxidant enzymes in the livers of animals exposed to TCDD and displayed a strong protective effect against HMN. It can be concluded that propolis has beneficial influences and was able to antagonize TCDD toxicity in the liver. |
| doi_str_mv | 10.1177/0748233712440139 |
| format | Article |
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Propolis exhibits antioxidant properties and several studies suggest that supplementations with antioxidants can influence hepatotoxicity. Therefore, the aim of the current study was to explore the effectiveness of propolis in alleviating the toxicity of TCDD in the liver of rats. Animals were divided into six groups, namely, TCDD (0.75 and 8 µg/kg body weight (bw)), propolis (50 mg/kg bw), TCDD (0.75 and 8 µg) plus propolis (50 mg/kg bw), and control, respectively. Rats were intraperitoneally administered with their respective doses daily for 21 days. In rats that received a high dose of TCDD, the antioxidant enzymes were significantly decreased and the serious pathological findings were established. Also, the rate of hepatocyte micronucleus (HMN) was increased after treating with TCDD. The reactions of enzymes in control and low-dose group were weak. The frequencies of HMN and liver histology were similar to both the groups. The presence of propolis with TCDD alleviated its pathological effects in hepatic tissue. Propolis also prevented the suppression of antioxidant enzymes in the livers of animals exposed to TCDD and displayed a strong protective effect against HMN. It can be concluded that propolis has beneficial influences and was able to antagonize TCDD toxicity in the liver.</description><identifier>ISSN: 0748-2337</identifier><identifier>EISSN: 1477-0393</identifier><identifier>DOI: 10.1177/0748233712440139</identifier><identifier>PMID: 22417774</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Antioxidants ; Antioxidants - pharmacology ; Biology ; Chemical and Drug Induced Liver Injury - drug therapy ; Dioxins ; DNA damage ; DNA Damage - drug effects ; Dose-Response Relationship, Drug ; Drug dosages ; Enzymes ; Flavonoids ; Free radicals ; Hepatocytes - drug effects ; Histopathology ; Laboratory animals ; Liver ; Liver - drug effects ; Liver - pathology ; Male ; Oxidative stress ; Oxidative Stress - drug effects ; Polychlorinated Dibenzodioxins - toxicity ; Propolis - pharmacology ; Rats ; Rats, Sprague-Dawley ; Toxicity ; Toxicology</subject><ispartof>Toxicology and industrial health, 2013-09, Vol.29 (8), p.677-685</ispartof><rights>The Author(s) 2012</rights><rights>SAGE Publications © Sep 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-c9ea965a78460d524dfd80c818079115c022ce7cd48d5b9f9a58340d7d4fa3543</citedby><cites>FETCH-LOGICAL-c398t-c9ea965a78460d524dfd80c818079115c022ce7cd48d5b9f9a58340d7d4fa3543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0748233712440139$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0748233712440139$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22417774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Türkez, Hasan</creatorcontrib><creatorcontrib>Geyikoğlu, Fatime</creatorcontrib><creatorcontrib>Yousef, Mokhtar I</creatorcontrib><creatorcontrib>Toğar, Basak</creatorcontrib><creatorcontrib>Vançelik, Serhat</creatorcontrib><title>Propolis alleviates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced histological changes, oxidative stress and DNA damage in rat liver</title><title>Toxicology and industrial health</title><addtitle>Toxicol Ind Health</addtitle><description>2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces hepatic damage. Propolis exhibits antioxidant properties and several studies suggest that supplementations with antioxidants can influence hepatotoxicity. Therefore, the aim of the current study was to explore the effectiveness of propolis in alleviating the toxicity of TCDD in the liver of rats. Animals were divided into six groups, namely, TCDD (0.75 and 8 µg/kg body weight (bw)), propolis (50 mg/kg bw), TCDD (0.75 and 8 µg) plus propolis (50 mg/kg bw), and control, respectively. Rats were intraperitoneally administered with their respective doses daily for 21 days. In rats that received a high dose of TCDD, the antioxidant enzymes were significantly decreased and the serious pathological findings were established. Also, the rate of hepatocyte micronucleus (HMN) was increased after treating with TCDD. The reactions of enzymes in control and low-dose group were weak. The frequencies of HMN and liver histology were similar to both the groups. The presence of propolis with TCDD alleviated its pathological effects in hepatic tissue. Propolis also prevented the suppression of antioxidant enzymes in the livers of animals exposed to TCDD and displayed a strong protective effect against HMN. It can be concluded that propolis has beneficial influences and was able to antagonize TCDD toxicity in the liver.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Biology</subject><subject>Chemical and Drug Induced Liver Injury - drug therapy</subject><subject>Dioxins</subject><subject>DNA damage</subject><subject>DNA Damage - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug dosages</subject><subject>Enzymes</subject><subject>Flavonoids</subject><subject>Free radicals</subject><subject>Hepatocytes - drug effects</subject><subject>Histopathology</subject><subject>Laboratory animals</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Polychlorinated Dibenzodioxins - toxicity</subject><subject>Propolis - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Toxicity</subject><subject>Toxicology</subject><issn>0748-2337</issn><issn>1477-0393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkb1vFDEQxS0EIkegp0KWaCjOwZ9ru4wCAaQIKEK98tmzd45868PejQIlf3l8XEBRJCSqKd7vvdHMQ-gloyeMaf2Wamm4EJpxKSkT9hFaMKk1ocKKx2ixl8leP0LPar2ilHad4k_REeey2bVcoF9fS97lFCt2KcF1dBNUzJdiqZeGXMJUnN-kXHKIKxh_ZrIjIeabOJI4htlDwJtYp5zyOnqXsN-4cQ11iRsS3BSvAdepQG3pY8DvPp_i4LZuDTiOuLgJp0aU5-jJ4FKFF3fzGH07f3959pFcfPnw6ez0gnhhzUS8BWc75bSRHQ2KyzAEQ71hhmrLmPKUcw_aB2mCWtnBOmWEpEEHOTihpDhGbw65u5K_z1Cnfhurh5TcCHmuPZPCctEZbf8HpUYqq3lDXz9Ar_JcxnbIb4oryu1-Nz1QvuRaCwz9rsStKz96Rvt9lf3DKpvl1V3wvNpC-Gv4010DyAGo7aP3tv4r8Ba9MqTA</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Türkez, Hasan</creator><creator>Geyikoğlu, Fatime</creator><creator>Yousef, Mokhtar I</creator><creator>Toğar, Basak</creator><creator>Vançelik, Serhat</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T2</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8BQ</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7X8</scope><scope>7TM</scope><scope>7U2</scope></search><sort><creationdate>20130901</creationdate><title>Propolis alleviates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced histological changes, oxidative stress and DNA damage in rat liver</title><author>Türkez, Hasan ; Geyikoğlu, Fatime ; Yousef, Mokhtar I ; Toğar, Basak ; Vançelik, Serhat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-c9ea965a78460d524dfd80c818079115c022ce7cd48d5b9f9a58340d7d4fa3543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - 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Academic</collection><collection>Nucleic Acids Abstracts</collection><collection>Safety Science and Risk</collection><jtitle>Toxicology and industrial health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Türkez, Hasan</au><au>Geyikoğlu, Fatime</au><au>Yousef, Mokhtar I</au><au>Toğar, Basak</au><au>Vançelik, Serhat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Propolis alleviates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced histological changes, oxidative stress and DNA damage in rat liver</atitle><jtitle>Toxicology and industrial health</jtitle><addtitle>Toxicol Ind Health</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>29</volume><issue>8</issue><spage>677</spage><epage>685</epage><pages>677-685</pages><issn>0748-2337</issn><eissn>1477-0393</eissn><abstract>2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces hepatic damage. Propolis exhibits antioxidant properties and several studies suggest that supplementations with antioxidants can influence hepatotoxicity. Therefore, the aim of the current study was to explore the effectiveness of propolis in alleviating the toxicity of TCDD in the liver of rats. Animals were divided into six groups, namely, TCDD (0.75 and 8 µg/kg body weight (bw)), propolis (50 mg/kg bw), TCDD (0.75 and 8 µg) plus propolis (50 mg/kg bw), and control, respectively. Rats were intraperitoneally administered with their respective doses daily for 21 days. In rats that received a high dose of TCDD, the antioxidant enzymes were significantly decreased and the serious pathological findings were established. Also, the rate of hepatocyte micronucleus (HMN) was increased after treating with TCDD. The reactions of enzymes in control and low-dose group were weak. The frequencies of HMN and liver histology were similar to both the groups. The presence of propolis with TCDD alleviated its pathological effects in hepatic tissue. Propolis also prevented the suppression of antioxidant enzymes in the livers of animals exposed to TCDD and displayed a strong protective effect against HMN. It can be concluded that propolis has beneficial influences and was able to antagonize TCDD toxicity in the liver.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>22417774</pmid><doi>10.1177/0748233712440139</doi><tpages>9</tpages></addata></record> |
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| ispartof | Toxicology and industrial health, 2013-09, Vol.29 (8), p.677-685 |
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| subjects | Animals Antioxidants Antioxidants - pharmacology Biology Chemical and Drug Induced Liver Injury - drug therapy Dioxins DNA damage DNA Damage - drug effects Dose-Response Relationship, Drug Drug dosages Enzymes Flavonoids Free radicals Hepatocytes - drug effects Histopathology Laboratory animals Liver Liver - drug effects Liver - pathology Male Oxidative stress Oxidative Stress - drug effects Polychlorinated Dibenzodioxins - toxicity Propolis - pharmacology Rats Rats, Sprague-Dawley Toxicity Toxicology |
| title | Propolis alleviates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced histological changes, oxidative stress and DNA damage in rat liver |
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