Effect of Somatostatin on Presynaptic and Postsynaptic Glutamate Receptors and Postsynaptic GABA Receptors in the Neurons of Rat Brain

We studied the effect of somatostatin on presinaptic NMDA receptors and postsinaptic GABA, NMDA, and AMPA receptors in rat brain. It was shown that somatostatin inhibits NMDAinduced 45 Ca 2+ uptake into synaptosomes isolated from rat brain cortex (IC 50 =2.8×10 –11 M). Somatostatin potentiates AMPA...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2012-11, Vol.154 (1), p.10-12
Hauptverfasser:	Grigoriev, V. V., Petrova, L. N., Gabrelian, A. V., Zamoyski, V. L., Serkova, T. P., Bachurin, S. O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Brain Brain - drug effects Brain - metabolism Calcium - metabolism Cell Biology Corticotropin-Like Intermediate Lobe Peptide - metabolism Drug Synergism GABA gamma-Aminobutyric Acid - pharmacology Glutamate Internal Medicine Ion Transport - drug effects Kainic Acid - pharmacology Laboratory Medicine Methyl aspartate N-Methylaspartate - pharmacology Neurons Neurons - drug effects Neurons - metabolism Patch-Clamp Techniques Pathology Rats Receptors, AMPA - metabolism Receptors, GABA - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Somatostatin - pharmacology Synaptic Transmission - drug effects Synaptosomes - drug effects Synaptosomes - metabolism
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