Effects of age and gender on neuroanatomical volumes
Purpose: To investigate age‐related differences, gender differences, and age‐by‐gender interactions on the volumes of 18 neuroanatomical structures, with a large sample at a single institution. Materials and Methods: A total of 861 normal subjects (mean age = 56.1 ± 9.8 years, age range = 24.0–84.8...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2013-05, Vol.37 (5), p.1072-1076 |
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| container_title | Journal of magnetic resonance imaging |
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| creator | Inano, Sachiko Takao, Hidemasa Hayashi, Naoto Yoshioka, Naoki Mori, Harushi Kunimatsu, Akira Abe, Osamu Ohtomo, Kuni |
| description | Purpose:
To investigate age‐related differences, gender differences, and age‐by‐gender interactions on the volumes of 18 neuroanatomical structures, with a large sample at a single institution.
Materials and Methods:
A total of 861 normal subjects (mean age = 56.1 ± 9.8 years, age range = 24.0–84.8 years) were included in this study. All subjects were scanned at 3.0 T. Measurement of the 18 neuroanatomical volumes was performed with FreeSurfer v. 4.5. Differences in volumes of neuroanatomical structures were tested using analysis of covariance with intracranial volume‐normalized volume as the dependent variable, and independent variables of age, sex, age × sex, age × age, age × age × sex, and scanner. Nonsignificant higher‐order terms were removed sequentially from the model. A P value of < 0.0028 (=0.5/18) was considered to indicate a statistically significant difference.
Results:
All neuroanatomical volumes, except for the caudate nucleus, pallidum, and 4th ventricle, were significantly related to age (linearly or quadratically). Significant gender differences were found in all neuroanatomical volumes, except for cerebral white matter, cerebellar cortex, caudate nucleus, and amygdala. No neuroanatomical volume showed a significant interaction between age (age × age) and gender.
Conclusion:
Our results showed age and gender effects on neuroanatomical volumes, and indicate no gender difference in the aging process of neuroanatomical volumes. J. Magn. Reson. Imaging 2013;37:1072–1076. © 2012 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmri.23910 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1439235581</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1338394623</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5300-b7e2680ea1c58e7ab72c3ca2331323f1f628785948507627c7a51a0700c1a2b73</originalsourceid><addsrcrecordid>eNqFkE1P3DAQhq2qqMDSCz8AReqlQgqMZ-LYObYIKGgBCVFxtLzeCco2icHe8PHvG1jgwKG9zMzhmWc0rxDbEvYkAO4vutjsIVUSPokNqRBzVKb8PM6gKJcG9LrYTGkBAFVVqC9iHUkqKDRsiOKwrtkvUxbqzN1w5vp5dsP9nGMW-qznIQbXu2XoGu_a7D60Q8dpS6zVrk389bVPxO-jw6uDX_n04vjk4Mc094oA8plmLA2wk14Z1m6m0ZN3SCQJqZZ1iUYbVRVGgS5Re-2UdKABvHQ40zQR31fe2xjuBk5L2zXJc9u6nsOQrCyoQlLKyP-jRIaqohyPT8S3D-giDLEfHxkpNKQNjnUidleUjyGlyLW9jU3n4pOVYJ9jt8-x25fYR3jnVTnMOp6_o285j4BcAQ9Ny0__UNnTs8uTN2m-2mnSkh_fd1z8Y0tNWtnr82OrTuFaYfHTTukvGhWX9w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1328378228</pqid></control><display><type>article</type><title>Effects of age and gender on neuroanatomical volumes</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><creator>Inano, Sachiko ; Takao, Hidemasa ; Hayashi, Naoto ; Yoshioka, Naoki ; Mori, Harushi ; Kunimatsu, Akira ; Abe, Osamu ; Ohtomo, Kuni</creator><creatorcontrib>Inano, Sachiko ; Takao, Hidemasa ; Hayashi, Naoto ; Yoshioka, Naoki ; Mori, Harushi ; Kunimatsu, Akira ; Abe, Osamu ; Ohtomo, Kuni</creatorcontrib><description>Purpose:
To investigate age‐related differences, gender differences, and age‐by‐gender interactions on the volumes of 18 neuroanatomical structures, with a large sample at a single institution.
Materials and Methods:
A total of 861 normal subjects (mean age = 56.1 ± 9.8 years, age range = 24.0–84.8 years) were included in this study. All subjects were scanned at 3.0 T. Measurement of the 18 neuroanatomical volumes was performed with FreeSurfer v. 4.5. Differences in volumes of neuroanatomical structures were tested using analysis of covariance with intracranial volume‐normalized volume as the dependent variable, and independent variables of age, sex, age × sex, age × age, age × age × sex, and scanner. Nonsignificant higher‐order terms were removed sequentially from the model. A P value of < 0.0028 (=0.5/18) was considered to indicate a statistically significant difference.
Results:
All neuroanatomical volumes, except for the caudate nucleus, pallidum, and 4th ventricle, were significantly related to age (linearly or quadratically). Significant gender differences were found in all neuroanatomical volumes, except for cerebral white matter, cerebellar cortex, caudate nucleus, and amygdala. No neuroanatomical volume showed a significant interaction between age (age × age) and gender.
Conclusion:
Our results showed age and gender effects on neuroanatomical volumes, and indicate no gender difference in the aging process of neuroanatomical volumes. J. Magn. Reson. Imaging 2013;37:1072–1076. © 2012 Wiley Periodicals, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.23910</identifier><identifier>PMID: 23150470</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Age Distribution ; Aged ; Aged, 80 and over ; aging ; Aging - pathology ; Aging - physiology ; Brain - anatomy & histology ; Brain - physiology ; Brain Mapping - statistics & numerical data ; brain volume ; dimorphism ; Female ; Humans ; Japan - epidemiology ; Magnetic resonance imaging ; Magnetic Resonance Imaging - statistics & numerical data ; Male ; Middle Aged ; Organ Size - physiology ; sex differences ; Sex Distribution</subject><ispartof>Journal of magnetic resonance imaging, 2013-05, Vol.37 (5), p.1072-1076</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5300-b7e2680ea1c58e7ab72c3ca2331323f1f628785948507627c7a51a0700c1a2b73</citedby><cites>FETCH-LOGICAL-c5300-b7e2680ea1c58e7ab72c3ca2331323f1f628785948507627c7a51a0700c1a2b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.23910$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.23910$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23150470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inano, Sachiko</creatorcontrib><creatorcontrib>Takao, Hidemasa</creatorcontrib><creatorcontrib>Hayashi, Naoto</creatorcontrib><creatorcontrib>Yoshioka, Naoki</creatorcontrib><creatorcontrib>Mori, Harushi</creatorcontrib><creatorcontrib>Kunimatsu, Akira</creatorcontrib><creatorcontrib>Abe, Osamu</creatorcontrib><creatorcontrib>Ohtomo, Kuni</creatorcontrib><title>Effects of age and gender on neuroanatomical volumes</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose:
To investigate age‐related differences, gender differences, and age‐by‐gender interactions on the volumes of 18 neuroanatomical structures, with a large sample at a single institution.
Materials and Methods:
A total of 861 normal subjects (mean age = 56.1 ± 9.8 years, age range = 24.0–84.8 years) were included in this study. All subjects were scanned at 3.0 T. Measurement of the 18 neuroanatomical volumes was performed with FreeSurfer v. 4.5. Differences in volumes of neuroanatomical structures were tested using analysis of covariance with intracranial volume‐normalized volume as the dependent variable, and independent variables of age, sex, age × sex, age × age, age × age × sex, and scanner. Nonsignificant higher‐order terms were removed sequentially from the model. A P value of < 0.0028 (=0.5/18) was considered to indicate a statistically significant difference.
Results:
All neuroanatomical volumes, except for the caudate nucleus, pallidum, and 4th ventricle, were significantly related to age (linearly or quadratically). Significant gender differences were found in all neuroanatomical volumes, except for cerebral white matter, cerebellar cortex, caudate nucleus, and amygdala. No neuroanatomical volume showed a significant interaction between age (age × age) and gender.
Conclusion:
Our results showed age and gender effects on neuroanatomical volumes, and indicate no gender difference in the aging process of neuroanatomical volumes. J. Magn. Reson. Imaging 2013;37:1072–1076. © 2012 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>aging</subject><subject>Aging - pathology</subject><subject>Aging - physiology</subject><subject>Brain - anatomy & histology</subject><subject>Brain - physiology</subject><subject>Brain Mapping - statistics & numerical data</subject><subject>brain volume</subject><subject>dimorphism</subject><subject>Female</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - statistics & numerical data</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Organ Size - physiology</subject><subject>sex differences</subject><subject>Sex Distribution</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq2qqMDSCz8AReqlQgqMZ-LYObYIKGgBCVFxtLzeCco2icHe8PHvG1jgwKG9zMzhmWc0rxDbEvYkAO4vutjsIVUSPokNqRBzVKb8PM6gKJcG9LrYTGkBAFVVqC9iHUkqKDRsiOKwrtkvUxbqzN1w5vp5dsP9nGMW-qznIQbXu2XoGu_a7D60Q8dpS6zVrk389bVPxO-jw6uDX_n04vjk4Mc094oA8plmLA2wk14Z1m6m0ZN3SCQJqZZ1iUYbVRVGgS5Re-2UdKABvHQ40zQR31fe2xjuBk5L2zXJc9u6nsOQrCyoQlLKyP-jRIaqohyPT8S3D-giDLEfHxkpNKQNjnUidleUjyGlyLW9jU3n4pOVYJ9jt8-x25fYR3jnVTnMOp6_o285j4BcAQ9Ny0__UNnTs8uTN2m-2mnSkh_fd1z8Y0tNWtnr82OrTuFaYfHTTukvGhWX9w</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Inano, Sachiko</creator><creator>Takao, Hidemasa</creator><creator>Hayashi, Naoto</creator><creator>Yoshioka, Naoki</creator><creator>Mori, Harushi</creator><creator>Kunimatsu, Akira</creator><creator>Abe, Osamu</creator><creator>Ohtomo, Kuni</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201305</creationdate><title>Effects of age and gender on neuroanatomical volumes</title><author>Inano, Sachiko ; Takao, Hidemasa ; Hayashi, Naoto ; Yoshioka, Naoki ; Mori, Harushi ; Kunimatsu, Akira ; Abe, Osamu ; Ohtomo, Kuni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5300-b7e2680ea1c58e7ab72c3ca2331323f1f628785948507627c7a51a0700c1a2b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>aging</topic><topic>Aging - pathology</topic><topic>Aging - physiology</topic><topic>Brain - anatomy & histology</topic><topic>Brain - physiology</topic><topic>Brain Mapping - statistics & numerical data</topic><topic>brain volume</topic><topic>dimorphism</topic><topic>Female</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - statistics & numerical data</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Organ Size - physiology</topic><topic>sex differences</topic><topic>Sex Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inano, Sachiko</creatorcontrib><creatorcontrib>Takao, Hidemasa</creatorcontrib><creatorcontrib>Hayashi, Naoto</creatorcontrib><creatorcontrib>Yoshioka, Naoki</creatorcontrib><creatorcontrib>Mori, Harushi</creatorcontrib><creatorcontrib>Kunimatsu, Akira</creatorcontrib><creatorcontrib>Abe, Osamu</creatorcontrib><creatorcontrib>Ohtomo, Kuni</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inano, Sachiko</au><au>Takao, Hidemasa</au><au>Hayashi, Naoto</au><au>Yoshioka, Naoki</au><au>Mori, Harushi</au><au>Kunimatsu, Akira</au><au>Abe, Osamu</au><au>Ohtomo, Kuni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of age and gender on neuroanatomical volumes</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2013-05</date><risdate>2013</risdate><volume>37</volume><issue>5</issue><spage>1072</spage><epage>1076</epage><pages>1072-1076</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose:
To investigate age‐related differences, gender differences, and age‐by‐gender interactions on the volumes of 18 neuroanatomical structures, with a large sample at a single institution.
Materials and Methods:
A total of 861 normal subjects (mean age = 56.1 ± 9.8 years, age range = 24.0–84.8 years) were included in this study. All subjects were scanned at 3.0 T. Measurement of the 18 neuroanatomical volumes was performed with FreeSurfer v. 4.5. Differences in volumes of neuroanatomical structures were tested using analysis of covariance with intracranial volume‐normalized volume as the dependent variable, and independent variables of age, sex, age × sex, age × age, age × age × sex, and scanner. Nonsignificant higher‐order terms were removed sequentially from the model. A P value of < 0.0028 (=0.5/18) was considered to indicate a statistically significant difference.
Results:
All neuroanatomical volumes, except for the caudate nucleus, pallidum, and 4th ventricle, were significantly related to age (linearly or quadratically). Significant gender differences were found in all neuroanatomical volumes, except for cerebral white matter, cerebellar cortex, caudate nucleus, and amygdala. No neuroanatomical volume showed a significant interaction between age (age × age) and gender.
Conclusion:
Our results showed age and gender effects on neuroanatomical volumes, and indicate no gender difference in the aging process of neuroanatomical volumes. J. Magn. Reson. Imaging 2013;37:1072–1076. © 2012 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>23150470</pmid><doi>10.1002/jmri.23910</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of magnetic resonance imaging, 2013-05, Vol.37 (5), p.1072-1076 |
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| subjects | Adult Age Distribution Aged Aged, 80 and over aging Aging - pathology Aging - physiology Brain - anatomy & histology Brain - physiology Brain Mapping - statistics & numerical data brain volume dimorphism Female Humans Japan - epidemiology Magnetic resonance imaging Magnetic Resonance Imaging - statistics & numerical data Male Middle Aged Organ Size - physiology sex differences Sex Distribution |
| title | Effects of age and gender on neuroanatomical volumes |
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