Suppressive effect of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on hepatitis C virus replication

The histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) has a clinical promise for treatment of cancer including hepatocellular carcinoma (HCC). To investigate effect of SAHA on hepatitis C virus (HCV) replication, we treated the HCV replicon cell OR6 with SAHA. HCV replicati...

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Veröffentlicht in:	Journal of cellular biochemistry 2013-09, Vol.114 (9), p.1987-1996
Hauptverfasser:	Sato, Ayami, Saito, Yoshimasa, Sugiyama, Kazuo, Sakasegawa, Noriko, Muramatsu, Toshihide, Fukuda, Shinya, Yoneya, Mikiko, Kimura, Masaki, Ebinuma, Hirotoshi, Hibi, Toshifumi, Ikeda, Masanori, Kato, Nobuyuki, Saito, Hidetsugu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals APOLIPOPROTEIN-A1 Blotting, Western Cell Line Chronic infection Hepacivirus - drug effects HEPATITIS C VIRUS Histone Deacetylase Inhibitors - pharmacology Hydroxamic Acids - pharmacology MIR-122 OR6 OSTEOPONTIN Osteopontin - genetics Reverse Transcriptase Polymerase Chain Reaction SUBEROYLANILIDE HYDROXAMIC ACID Virus Replication - drug effects
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