Orchestration of Inflammation and Adaptive Immunity in Borrelia burgdorferi–Induced Arthritis by Neutrophil‐Activating Protein A

Objective Lyme arthritis (LA) is characterized by infiltration of inflammatory cells, mainly neutrophils (polymorphonuclear cells [PMNs]) and T cells, into the joints. This study was undertaken to evaluate the role of the neutrophil‐activating protein A (NapA) of Borrelia burgdorferi in eliciting in...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2013-05, Vol.65 (5), p.1232-1242
Hauptverfasser:	Codolo, Gaia, Bossi, Fleur, Durigutto, Paolo, Bella, Chiara Della, Fischetti, Fabio, Amedei, Amedeo, Tedesco, Francesco, D'Elios, Sofia, Cimmino, Marco, Micheletti, Alessandra, Cassatella, Marco A., D'Elios, Mario M., de Bernard, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - immunology Animals Arthritis, Infectious - etiology Arthritis, Infectious - immunology Arthritis, Infectious - pathology Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Bacterial Proteins - administration & dosage Bacterial Proteins - immunology Bacterial Proteins - metabolism Borrelia burgdorferi Borrelia burgdorferi - physiology Cells Chemokines Chemokines - analysis Chemokines - metabolism Chemokines, CXC - administration & dosage Chemokines, CXC - immunology Chemokines, CXC - metabolism Chemotaxis - drug effects Female Flow Cytometry Humans Injections, Intra-Articular Knee Joint - metabolism Knee Joint - pathology Lyme Disease - complications Lyme Disease - immunology Lyme Disease - pathology Lymphocytes Male Medical research Middle Aged Neutrophil Infiltration Neutrophils - immunology Neutrophils - metabolism Neutrophils - pathology Rats Stifle - drug effects Stifle - pathology Synovial Fluid - chemistry Synovial Fluid - metabolism Synovial Membrane - pathology T-Lymphocytes - metabolism T-Lymphocytes - pathology
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