Antibacterial and Antimycobacterial Lignans and Flavonoids from Larrea tridentata
Three lignans and four flavonoids were isolated and characterized from Larrea tridentata and compounds were tested against 16 bacterial species/strains. Results showed that: dihydroguaiaretic acid (1) had activity towards methicillin resistant (MR) Staphylococcus aureus (minimum inhibitory concentra...
Gespeichert in:
| Veröffentlicht in: | Phytotherapy research 2012-12, Vol.26 (12), p.1957-1960 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1960 |
|---|---|
| container_issue | 12 |
| container_start_page | 1957 |
| container_title | Phytotherapy research |
| container_volume | 26 |
| creator | Favela-Hernández, J. M. J. García, A. Garza-González, E. Rivas-Galindo, V. M. Camacho-Corona, M. R. |
| description | Three lignans and four flavonoids were isolated and characterized from Larrea tridentata and compounds were tested against 16 bacterial species/strains. Results showed that: dihydroguaiaretic acid (1) had activity towards methicillin resistant (MR) Staphylococcus aureus (minimum inhibitory concentration (MIC) 50 µg/mL) and multidrug‐resistant (MDR) strains of Mycobacterium tuberculosis (MIC 12.5–50 µg/mL); 4‐epi‐larreatricin (2) was active against Enterobacter cloacae (MIC 12.5 µg/mL), as well as sensitive (MIC 50 µg/mL) and MDR strains of M. tuberculosis (MIC 25 µg/mL). 3′‐Demethoxy‐6‐O‐demethylisoguaiacin (3) displayed activity against sensitive and resistant S. aureus (MIC 25 µg/mL), Enterococcus faecalis (MIC 12.5 µg/mL), Escherichia coli (MIC 50 µg/mL), E. cloacae (MIC 12.5 µg/mL) and MDR strains of M. tuberculosis (MIC 12.5 µg/mL). 5,4′‐Dihydroxy‐3,7,8,3′‐tetramethoxyflavone (4) and 5,4′‐dihydroxy‐3,7,8‐trimethoxyflavone (5) were active against M. tuberculosis MDR strains having MIC values of 25 and 25–50 µg/mL, respectively, while 5,4′‐dihydroxy‐7‐methoxyflavone (6) was active against S. aureus (MIC 50 µg/mL) and E. faecalis (MIC 50 µg/mL). We concluded that lignan 3 is the main compound responsible for the antibacterial activity of L. tridentata. Lignans 1 and 2 as well as flavonoid 6 contribute with some degree of antibacterial activity. On the other hand, compounds 1, 2, 3, 4 and 5 contributed to the antimycobacterial activity found in L. tridentata. Copyright © 2012 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.4660 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1439231809</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1238104655</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4500-7bb76bd0da7c8613f92f62762abe3de81cd587b4b098a70746073ad24070d3cc3</originalsourceid><addsrcrecordid>eNqF0V1rFDEUBuAgil2r4C-QARG8mfbke-ayFNsKQ121Yu_CmSQjqfOxJrPq_ntn2rELBfEqcPLwHpKXkJcUjigAO96M8UgoBY_IikJZ5lRq_pisoJQ0F7S4PiDPUroBgJKBeEoOGBOMKZAr8vGkH0ONdvQxYJth77J50u3ssJ9W4VuPfbq9PWvx59APwaWsiUOXVRijx2yMwfl-xBGfkycNtsm_WM5D8uXs3dXpRV59OH9_elLlVkiAXNe1VrUDh9oWivKmZI1iWjGsPXe-oNbJQteihrJADVoo0BwdE6DBcWv5IXl7l7uJw4-tT6PpQrK-bbH3wzYZKnjJOC2g_D9lvKAglJQTff2A3gzb2E8PmRVIqYSGfaCNQ0rRN2YTQ4dxZyiYuREzNWLmRib6agnc1p139_BvBRN4swBMFtsmYm9D2js1_YkQc1B-536F1u_-udCsrz4tixcf0uh_33uM343SXEvz9fLcfJbXa7qu1uaC_wGUUa9Y</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1230556470</pqid></control><display><type>article</type><title>Antibacterial and Antimycobacterial Lignans and Flavonoids from Larrea tridentata</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Favela-Hernández, J. M. J. ; García, A. ; Garza-González, E. ; Rivas-Galindo, V. M. ; Camacho-Corona, M. R.</creator><creatorcontrib>Favela-Hernández, J. M. J. ; García, A. ; Garza-González, E. ; Rivas-Galindo, V. M. ; Camacho-Corona, M. R.</creatorcontrib><description>Three lignans and four flavonoids were isolated and characterized from Larrea tridentata and compounds were tested against 16 bacterial species/strains. Results showed that: dihydroguaiaretic acid (1) had activity towards methicillin resistant (MR) Staphylococcus aureus (minimum inhibitory concentration (MIC) 50 µg/mL) and multidrug‐resistant (MDR) strains of Mycobacterium tuberculosis (MIC 12.5–50 µg/mL); 4‐epi‐larreatricin (2) was active against Enterobacter cloacae (MIC 12.5 µg/mL), as well as sensitive (MIC 50 µg/mL) and MDR strains of M. tuberculosis (MIC 25 µg/mL). 3′‐Demethoxy‐6‐O‐demethylisoguaiacin (3) displayed activity against sensitive and resistant S. aureus (MIC 25 µg/mL), Enterococcus faecalis (MIC 12.5 µg/mL), Escherichia coli (MIC 50 µg/mL), E. cloacae (MIC 12.5 µg/mL) and MDR strains of M. tuberculosis (MIC 12.5 µg/mL). 5,4′‐Dihydroxy‐3,7,8,3′‐tetramethoxyflavone (4) and 5,4′‐dihydroxy‐3,7,8‐trimethoxyflavone (5) were active against M. tuberculosis MDR strains having MIC values of 25 and 25–50 µg/mL, respectively, while 5,4′‐dihydroxy‐7‐methoxyflavone (6) was active against S. aureus (MIC 50 µg/mL) and E. faecalis (MIC 50 µg/mL). We concluded that lignan 3 is the main compound responsible for the antibacterial activity of L. tridentata. Lignans 1 and 2 as well as flavonoid 6 contribute with some degree of antibacterial activity. On the other hand, compounds 1, 2, 3, 4 and 5 contributed to the antimycobacterial activity found in L. tridentata. Copyright © 2012 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.4660</identifier><identifier>PMID: 22422605</identifier><identifier>CODEN: PHYREH</identifier><language>eng</language><publisher>Chichester: Blackwell Publishing Ltd</publisher><subject>Anti-Bacterial Agents - pharmacology ; antibacterial ; Antibacterial activity ; antimycobacterial ; Bacteria - drug effects ; Biological and medical sciences ; Enterobacter cloacae ; flavonoids ; Flavonoids - isolation & purification ; Flavonoids - pharmacology ; General pharmacology ; Larrea - chemistry ; Larrea tridentate ; lignans ; Lignans - isolation & purification ; Lignans - pharmacology ; Medical sciences ; Microbial Sensitivity Tests ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - pharmacology ; Plant Leaves - chemistry</subject><ispartof>Phytotherapy research, 2012-12, Vol.26 (12), p.1957-1960</ispartof><rights>Copyright © 2012 John Wiley & Sons, Ltd.</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4500-7bb76bd0da7c8613f92f62762abe3de81cd587b4b098a70746073ad24070d3cc3</citedby><cites>FETCH-LOGICAL-c4500-7bb76bd0da7c8613f92f62762abe3de81cd587b4b098a70746073ad24070d3cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.4660$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.4660$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26762440$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22422605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Favela-Hernández, J. M. J.</creatorcontrib><creatorcontrib>García, A.</creatorcontrib><creatorcontrib>Garza-González, E.</creatorcontrib><creatorcontrib>Rivas-Galindo, V. M.</creatorcontrib><creatorcontrib>Camacho-Corona, M. R.</creatorcontrib><title>Antibacterial and Antimycobacterial Lignans and Flavonoids from Larrea tridentata</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Three lignans and four flavonoids were isolated and characterized from Larrea tridentata and compounds were tested against 16 bacterial species/strains. Results showed that: dihydroguaiaretic acid (1) had activity towards methicillin resistant (MR) Staphylococcus aureus (minimum inhibitory concentration (MIC) 50 µg/mL) and multidrug‐resistant (MDR) strains of Mycobacterium tuberculosis (MIC 12.5–50 µg/mL); 4‐epi‐larreatricin (2) was active against Enterobacter cloacae (MIC 12.5 µg/mL), as well as sensitive (MIC 50 µg/mL) and MDR strains of M. tuberculosis (MIC 25 µg/mL). 3′‐Demethoxy‐6‐O‐demethylisoguaiacin (3) displayed activity against sensitive and resistant S. aureus (MIC 25 µg/mL), Enterococcus faecalis (MIC 12.5 µg/mL), Escherichia coli (MIC 50 µg/mL), E. cloacae (MIC 12.5 µg/mL) and MDR strains of M. tuberculosis (MIC 12.5 µg/mL). 5,4′‐Dihydroxy‐3,7,8,3′‐tetramethoxyflavone (4) and 5,4′‐dihydroxy‐3,7,8‐trimethoxyflavone (5) were active against M. tuberculosis MDR strains having MIC values of 25 and 25–50 µg/mL, respectively, while 5,4′‐dihydroxy‐7‐methoxyflavone (6) was active against S. aureus (MIC 50 µg/mL) and E. faecalis (MIC 50 µg/mL). We concluded that lignan 3 is the main compound responsible for the antibacterial activity of L. tridentata. Lignans 1 and 2 as well as flavonoid 6 contribute with some degree of antibacterial activity. On the other hand, compounds 1, 2, 3, 4 and 5 contributed to the antimycobacterial activity found in L. tridentata. Copyright © 2012 John Wiley & Sons, Ltd.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>antibacterial</subject><subject>Antibacterial activity</subject><subject>antimycobacterial</subject><subject>Bacteria - drug effects</subject><subject>Biological and medical sciences</subject><subject>Enterobacter cloacae</subject><subject>flavonoids</subject><subject>Flavonoids - isolation & purification</subject><subject>Flavonoids - pharmacology</subject><subject>General pharmacology</subject><subject>Larrea - chemistry</subject><subject>Larrea tridentate</subject><subject>lignans</subject><subject>Lignans - isolation & purification</subject><subject>Lignans - pharmacology</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - chemistry</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0V1rFDEUBuAgil2r4C-QARG8mfbke-ayFNsKQ121Yu_CmSQjqfOxJrPq_ntn2rELBfEqcPLwHpKXkJcUjigAO96M8UgoBY_IikJZ5lRq_pisoJQ0F7S4PiDPUroBgJKBeEoOGBOMKZAr8vGkH0ONdvQxYJth77J50u3ssJ9W4VuPfbq9PWvx59APwaWsiUOXVRijx2yMwfl-xBGfkycNtsm_WM5D8uXs3dXpRV59OH9_elLlVkiAXNe1VrUDh9oWivKmZI1iWjGsPXe-oNbJQteihrJADVoo0BwdE6DBcWv5IXl7l7uJw4-tT6PpQrK-bbH3wzYZKnjJOC2g_D9lvKAglJQTff2A3gzb2E8PmRVIqYSGfaCNQ0rRN2YTQ4dxZyiYuREzNWLmRib6agnc1p139_BvBRN4swBMFtsmYm9D2js1_YkQc1B-536F1u_-udCsrz4tixcf0uh_33uM343SXEvz9fLcfJbXa7qu1uaC_wGUUa9Y</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Favela-Hernández, J. M. J.</creator><creator>García, A.</creator><creator>Garza-González, E.</creator><creator>Rivas-Galindo, V. M.</creator><creator>Camacho-Corona, M. R.</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7QL</scope><scope>7T7</scope><scope>C1K</scope></search><sort><creationdate>201212</creationdate><title>Antibacterial and Antimycobacterial Lignans and Flavonoids from Larrea tridentata</title><author>Favela-Hernández, J. M. J. ; García, A. ; Garza-González, E. ; Rivas-Galindo, V. M. ; Camacho-Corona, M. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4500-7bb76bd0da7c8613f92f62762abe3de81cd587b4b098a70746073ad24070d3cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>antibacterial</topic><topic>Antibacterial activity</topic><topic>antimycobacterial</topic><topic>Bacteria - drug effects</topic><topic>Biological and medical sciences</topic><topic>Enterobacter cloacae</topic><topic>flavonoids</topic><topic>Flavonoids - isolation & purification</topic><topic>Flavonoids - pharmacology</topic><topic>General pharmacology</topic><topic>Larrea - chemistry</topic><topic>Larrea tridentate</topic><topic>lignans</topic><topic>Lignans - isolation & purification</topic><topic>Lignans - pharmacology</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Favela-Hernández, J. M. J.</creatorcontrib><creatorcontrib>García, A.</creatorcontrib><creatorcontrib>Garza-González, E.</creatorcontrib><creatorcontrib>Rivas-Galindo, V. M.</creatorcontrib><creatorcontrib>Camacho-Corona, M. R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Favela-Hernández, J. M. J.</au><au>García, A.</au><au>Garza-González, E.</au><au>Rivas-Galindo, V. M.</au><au>Camacho-Corona, M. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibacterial and Antimycobacterial Lignans and Flavonoids from Larrea tridentata</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2012-12</date><risdate>2012</risdate><volume>26</volume><issue>12</issue><spage>1957</spage><epage>1960</epage><pages>1957-1960</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><coden>PHYREH</coden><abstract>Three lignans and four flavonoids were isolated and characterized from Larrea tridentata and compounds were tested against 16 bacterial species/strains. Results showed that: dihydroguaiaretic acid (1) had activity towards methicillin resistant (MR) Staphylococcus aureus (minimum inhibitory concentration (MIC) 50 µg/mL) and multidrug‐resistant (MDR) strains of Mycobacterium tuberculosis (MIC 12.5–50 µg/mL); 4‐epi‐larreatricin (2) was active against Enterobacter cloacae (MIC 12.5 µg/mL), as well as sensitive (MIC 50 µg/mL) and MDR strains of M. tuberculosis (MIC 25 µg/mL). 3′‐Demethoxy‐6‐O‐demethylisoguaiacin (3) displayed activity against sensitive and resistant S. aureus (MIC 25 µg/mL), Enterococcus faecalis (MIC 12.5 µg/mL), Escherichia coli (MIC 50 µg/mL), E. cloacae (MIC 12.5 µg/mL) and MDR strains of M. tuberculosis (MIC 12.5 µg/mL). 5,4′‐Dihydroxy‐3,7,8,3′‐tetramethoxyflavone (4) and 5,4′‐dihydroxy‐3,7,8‐trimethoxyflavone (5) were active against M. tuberculosis MDR strains having MIC values of 25 and 25–50 µg/mL, respectively, while 5,4′‐dihydroxy‐7‐methoxyflavone (6) was active against S. aureus (MIC 50 µg/mL) and E. faecalis (MIC 50 µg/mL). We concluded that lignan 3 is the main compound responsible for the antibacterial activity of L. tridentata. Lignans 1 and 2 as well as flavonoid 6 contribute with some degree of antibacterial activity. On the other hand, compounds 1, 2, 3, 4 and 5 contributed to the antimycobacterial activity found in L. tridentata. Copyright © 2012 John Wiley & Sons, Ltd.</abstract><cop>Chichester</cop><pub>Blackwell Publishing Ltd</pub><pmid>22422605</pmid><doi>10.1002/ptr.4660</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0951-418X |
| ispartof | Phytotherapy research, 2012-12, Vol.26 (12), p.1957-1960 |
| issn | 0951-418X 1099-1573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1439231809 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Anti-Bacterial Agents - pharmacology antibacterial Antibacterial activity antimycobacterial Bacteria - drug effects Biological and medical sciences Enterobacter cloacae flavonoids Flavonoids - isolation & purification Flavonoids - pharmacology General pharmacology Larrea - chemistry Larrea tridentate lignans Lignans - isolation & purification Lignans - pharmacology Medical sciences Microbial Sensitivity Tests Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Plant Leaves - chemistry |
| title | Antibacterial and Antimycobacterial Lignans and Flavonoids from Larrea tridentata |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T14%3A30%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antibacterial%20and%20Antimycobacterial%20Lignans%20and%20Flavonoids%20from%20Larrea%20tridentata&rft.jtitle=Phytotherapy%20research&rft.au=Favela-Hern%C3%A1ndez,%20J.%20M.%20J.&rft.date=2012-12&rft.volume=26&rft.issue=12&rft.spage=1957&rft.epage=1960&rft.pages=1957-1960&rft.issn=0951-418X&rft.eissn=1099-1573&rft.coden=PHYREH&rft_id=info:doi/10.1002/ptr.4660&rft_dat=%3Cproquest_cross%3E1238104655%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1230556470&rft_id=info:pmid/22422605&rfr_iscdi=true |