Phenolic Diterpenes from Rosemary Suppress cAMP Responsiveness of Gluconeogenic Gene Promoters

The cAMP/protein kinase A/cAMP response element (CRE)‐binding protein pathway is important for various physiological aspects including regulation of gluconeogenic gene expression. Rosemary, a well‐known herb, has been reported to decrease blood glucose levels. We found that methanol extracts of rose...

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Veröffentlicht in:	Phytotherapy research 2013-06, Vol.27 (6), p.906-910
Hauptverfasser:	Yun, Young Sook, Noda, Sachie, Shigemori, Genta, Kuriyama, Ryunosuke, Takahashi, Shigeru, Umemura, Mariko, Takahashi, Yuji, Inoue, Hideshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Colforsin CREB Cyclic AMP Response Element-Binding Protein - metabolism Diterpenes - pharmacology Flavonoids - pharmacology G6Pase Gene Expression Regulation, Enzymologic gluconeogenesis Gluconeogenesis - drug effects Glucose-6-Phosphatase - metabolism Hep G2 Cells Humans PEPCK Phosphoenolpyruvate Carboxykinase (GTP) - metabolism Plant Extracts - pharmacology Promoter Regions, Genetic - drug effects rosemary Rosmarinus Rosmarinus - chemistry
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