Pathomorphological and Immunohistochemical Analysis of Proliferative Activity of the Buccal Mucosal Epithelium in Lichen Planus
Structural reorganization of the buccal mucosa and changes in proliferative activity of epitheliocytes in typical and erosive ulcerative lichen planus were studied. The most manifest diagnostically significant pathomorphological signs of lichen planus of the buccal mucosa are described: acanthosis,...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2012-12, Vol.154 (2), p.283-286 |
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| container_title | Bulletin of experimental biology and medicine |
| container_volume | 154 |
| creator | Timoshin, S. S. Fleishman, M. Yu Zagorodnyaya, E. B. Oskol’skii, G. I. Zagorodnii, A. S. Lushnikova, E. L. Nepomnyashchikh, L. M. |
| description | Structural reorganization of the buccal mucosa and changes in proliferative activity of epitheliocytes in typical and erosive ulcerative lichen planus were studied. The most manifest diagnostically significant pathomorphological signs of lichen planus of the buccal mucosa are described: acanthosis, granulosis, parakeratosis, lymphocytic infiltration of the lamina propria, and edema. The most pronounced morphological changes and higher index of epitheliocyte proliferative activity (by expression of Ki-67) are characteristic of the erosive ulcerative form of the disease. |
| doi_str_mv | 10.1007/s10517-012-1931-1 |
| format | Article |
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S. ; Fleishman, M. Yu ; Zagorodnyaya, E. B. ; Oskol’skii, G. I. ; Zagorodnii, A. S. ; Lushnikova, E. L. ; Nepomnyashchikh, L. M.</creator><creatorcontrib>Timoshin, S. S. ; Fleishman, M. Yu ; Zagorodnyaya, E. B. ; Oskol’skii, G. I. ; Zagorodnii, A. S. ; Lushnikova, E. L. ; Nepomnyashchikh, L. M.</creatorcontrib><description>Structural reorganization of the buccal mucosa and changes in proliferative activity of epitheliocytes in typical and erosive ulcerative lichen planus were studied. The most manifest diagnostically significant pathomorphological signs of lichen planus of the buccal mucosa are described: acanthosis, granulosis, parakeratosis, lymphocytic infiltration of the lamina propria, and edema. 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The most pronounced morphological changes and higher index of epitheliocyte proliferative activity (by expression of Ki-67) are characteristic of the erosive ulcerative form of the disease.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Epithelium - metabolism</subject><subject>Epithelium - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunohistochemistry - methods</subject><subject>In Vitro Techniques</subject><subject>Internal Medicine</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Laboratory Medicine</subject><subject>Lichen planus</subject><subject>Lichen Planus - metabolism</subject><subject>Lichen Planus - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morphology and Pathomorphology</subject><subject>Mouth Mucosa - metabolism</subject><subject>Mouth Mucosa - pathology</subject><subject>Pathology</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkk9v1DAQxS0EoqXwAbigSEiIS4rHdhLnuK0KVFrEHuBseR1n48qxF_9B2hNfHYct0CIQymGU8e89ecYPoeeAzwHj7k0E3EBXYyA19BRqeIBOoelozQmBh-gUF6hmnPMT9CTGm-UXt_AYnRBKKQbGTtG3jUyTn33YT976nVHSVtIN1fU8Z-cnE5NXk55_9FdO2kM0sfJjtQnemlEHmcxXXa1UKSYdlpM06eoiq0XwISsfS73am9K1Js-VcdXaFEdXbax0OT5Fj0Zpo352W8_Q57dXny7f1-uP764vV-taNZimWnEJpOs7xba8TDgOPaXboR_GFoC00GGCByjboECYHmWj5KgardueELxlRNEz9Prouw_-S9YxidlEpW25hPY5CmC0JxRz3v0fJR1tW8o6XtCXf6A3PoeypsUQKMM9NOQ3tZNWC-NGn4JUi6lYUV7eoeGUFer8L1T5hmX93unRlP49was7gklLm6bobU7Gu3gfhCOogo8x6FHsg5llOAjAYgmSOAZJlCCJJUgCiubF7WR5O-vhl-JncgpAjkAsR26nw53R_-n6HSOq0J4</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Timoshin, S. 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S. ; Fleishman, M. Yu ; Zagorodnyaya, E. B. ; Oskol’skii, G. I. ; Zagorodnii, A. S. ; Lushnikova, E. L. ; Nepomnyashchikh, L. 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The most manifest diagnostically significant pathomorphological signs of lichen planus of the buccal mucosa are described: acanthosis, granulosis, parakeratosis, lymphocytic infiltration of the lamina propria, and edema. The most pronounced morphological changes and higher index of epitheliocyte proliferative activity (by expression of Ki-67) are characteristic of the erosive ulcerative form of the disease.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23330144</pmid><doi>10.1007/s10517-012-1931-1</doi><tpages>4</tpages></addata></record> |
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| ispartof | Bulletin of experimental biology and medicine, 2012-12, Vol.154 (2), p.283-286 |
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| subjects | Biomedical and Life Sciences Biomedicine Cell Biology Epithelium - metabolism Epithelium - pathology Female Humans Immunohistochemistry Immunohistochemistry - methods In Vitro Techniques Internal Medicine Ki-67 Antigen - metabolism Laboratory Medicine Lichen planus Lichen Planus - metabolism Lichen Planus - pathology Male Middle Aged Morphology and Pathomorphology Mouth Mucosa - metabolism Mouth Mucosa - pathology Pathology |
| title | Pathomorphological and Immunohistochemical Analysis of Proliferative Activity of the Buccal Mucosal Epithelium in Lichen Planus |
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