Quantitative Atlas of Blood–Brain Barrier Transporters, Receptors, and Tight Junction Proteins in Rats and Common Marmoset

The purpose of this study was to determine the protein amounts of blood–brain barrier (BBB) permeability-related transporters, receptors, and tight junction proteins in Sprague Dawley and Wistar rats and common marmoset, and also to investigate inter-species and inter-strain differences across roden...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2013-09, Vol.102 (9), p.3343-3355
Hauptverfasser:	Hoshi, Yutaro, Uchida, Yasuo, Tachikawa, Masanori, Inoue, Takashi, Ohtsuki, Sumio, Terasaki, Tetsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	ADME Animals Blood-Brain Barrier - chemistry blood–brain barrier Callithrix Female Humans Macaca Male Membrane Transport Proteins - analysis membrane transporter multidrug resistance transporters P-glycoprotein permeability preclinical pharmacokinetics Primates proteomics Rats Rats, Sprague-Dawley Rats, Wistar receptors Receptors, Cell Surface - analysis Species Specificity Tandem Mass Spectrometry tight junction Tight Junction Proteins - analysis
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