Fatty Acid Synthase Inhibition by Amentoflavone Suppresses HER2/neu (erbB2) Oncogene in SKBR3 Human Breast Cancer Cells

Fatty acid synthase (FASN) is a potential therapeutic target for treatment of cancer and obesity, and is highly elevated in 30% of HER2‐overexpressing breast cancers. Considerable interest has developed in searching for novel FASN inhibitors as therapeutic agents in treatment of HER2‐overexpressing...

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Veröffentlicht in:	Phytotherapy research 2013-05, Vol.27 (5), p.713-720
Hauptverfasser:	Lee, Jin Sun, Sul, Ji Young, Park, Jun Beom, Lee, Myung Sun, Cha, Eun Young, Song, In Sang, Kim, Je Ryong, Chang, Eil Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	amentoflavone Antineoplastic Agents - pharmacology Apoptosis - drug effects Biflavonoids - pharmacology breast cancer Breast Neoplasms - metabolism Cell Line, Tumor Cell Survival fatty acid synthase Fatty Acid Synthases - antagonists & inhibitors Female Gene Expression Regulation, Neoplastic - drug effects HER2/neu Humans Phosphorylation Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism
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