Identification of cellular factors required for the budding of koala retrovirus
ABSTRACT Koala retrovirus (KoRV) is a unique gammaretrovirus that is currently endogenizing into its host and considered to be associated with leukemia, lymphoma and immunosuppression in koalas (Phascolactos cinereus). In this study, it was demonstrated that WWP2 or WWP2‐like E3 ubiquitin ligases po...
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| Veröffentlicht in: | Microbiology and immunology 2013-07, Vol.57 (7), p.543-546 |
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| container_end_page | 546 |
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| container_title | Microbiology and immunology |
| container_volume | 57 |
| creator | Shimode, Sayumi Nakaoka, Rie Hoshino, Shigeki Abe, Masumi Shogen, Hiroko Yasuda, Jiro Miyazawa, Takayuki |
| description | ABSTRACT
Koala retrovirus (KoRV) is a unique gammaretrovirus that is currently endogenizing into its host and considered to be associated with leukemia, lymphoma and immunosuppression in koalas (Phascolactos cinereus). In this study, it was demonstrated that WWP2 or WWP2‐like E3 ubiquitin ligases possessing the WW domain closely related to WWP2 and Vps4A/B are involved in KoRV budding. These data suggest that KoRV Gag recruits the cellular endosomal sorting complex required for transport machinery through interaction of the PPPY L‐domain with the WW domain(s) of WWP2 and that progeny virions are released from cells by utilizing the multivesicular body sorting pathway. |
| doi_str_mv | 10.1111/1348-0421.12066 |
| format | Article |
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Koala retrovirus (KoRV) is a unique gammaretrovirus that is currently endogenizing into its host and considered to be associated with leukemia, lymphoma and immunosuppression in koalas (Phascolactos cinereus). In this study, it was demonstrated that WWP2 or WWP2‐like E3 ubiquitin ligases possessing the WW domain closely related to WWP2 and Vps4A/B are involved in KoRV budding. These data suggest that KoRV Gag recruits the cellular endosomal sorting complex required for transport machinery through interaction of the PPPY L‐domain with the WW domain(s) of WWP2 and that progeny virions are released from cells by utilizing the multivesicular body sorting pathway.</description><identifier>ISSN: 0385-5600</identifier><identifier>EISSN: 1348-0421</identifier><identifier>DOI: 10.1111/1348-0421.12066</identifier><identifier>PMID: 23651516</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Animals ; budding ; Cell Line ; Gammaretrovirus - physiology ; Gene Products, gag - metabolism ; host factors ; Host-Pathogen Interactions ; Humans ; koala retrovirus ; koalas ; Phascolarctidae ; Protein Binding ; Retrovirus ; Ubiquitin-Protein Ligases - metabolism ; Virus Release</subject><ispartof>Microbiology and immunology, 2013-07, Vol.57 (7), p.543-546</ispartof><rights>2013 The Societies and Wiley Publishing Asia Pty Ltd</rights><rights>2013 The Societies and Wiley Publishing Asia Pty Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5346-eba32e75872b5ba8780227cf35361a80078acd9396736ba352e2cf2e34dcb6363</citedby><cites>FETCH-LOGICAL-c5346-eba32e75872b5ba8780227cf35361a80078acd9396736ba352e2cf2e34dcb6363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1348-0421.12066$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1348-0421.12066$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23651516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimode, Sayumi</creatorcontrib><creatorcontrib>Nakaoka, Rie</creatorcontrib><creatorcontrib>Hoshino, Shigeki</creatorcontrib><creatorcontrib>Abe, Masumi</creatorcontrib><creatorcontrib>Shogen, Hiroko</creatorcontrib><creatorcontrib>Yasuda, Jiro</creatorcontrib><creatorcontrib>Miyazawa, Takayuki</creatorcontrib><title>Identification of cellular factors required for the budding of koala retrovirus</title><title>Microbiology and immunology</title><addtitle>Microbiol Immunol</addtitle><description>ABSTRACT
Koala retrovirus (KoRV) is a unique gammaretrovirus that is currently endogenizing into its host and considered to be associated with leukemia, lymphoma and immunosuppression in koalas (Phascolactos cinereus). In this study, it was demonstrated that WWP2 or WWP2‐like E3 ubiquitin ligases possessing the WW domain closely related to WWP2 and Vps4A/B are involved in KoRV budding. 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Koala retrovirus (KoRV) is a unique gammaretrovirus that is currently endogenizing into its host and considered to be associated with leukemia, lymphoma and immunosuppression in koalas (Phascolactos cinereus). In this study, it was demonstrated that WWP2 or WWP2‐like E3 ubiquitin ligases possessing the WW domain closely related to WWP2 and Vps4A/B are involved in KoRV budding. These data suggest that KoRV Gag recruits the cellular endosomal sorting complex required for transport machinery through interaction of the PPPY L‐domain with the WW domain(s) of WWP2 and that progeny virions are released from cells by utilizing the multivesicular body sorting pathway.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>23651516</pmid><doi>10.1111/1348-0421.12066</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Open Access Titles of Japan; Alma/SFX Local Collection |
| subjects | Animals budding Cell Line Gammaretrovirus - physiology Gene Products, gag - metabolism host factors Host-Pathogen Interactions Humans koala retrovirus koalas Phascolarctidae Protein Binding Retrovirus Ubiquitin-Protein Ligases - metabolism Virus Release |
| title | Identification of cellular factors required for the budding of koala retrovirus |
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