Microbes and mucosal immune responses in asthma

Summary The substantial increase in the worldwide prevalence of asthma and atopy has been attributed to lifestyle changes that reduce exposure to bacteria. A recent insight is that the largely bacterial microbiome maintains a state of basal immune homoeostasis, which modulates immune responses to mi...

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Veröffentlicht in:	The Lancet (British edition) 2013-03, Vol.381 (9869), p.861-873
Hauptverfasser:	Hansel, Trevor T, Dr, Johnston, Sebastian L, FRCP, Openshaw, Peter J, FMed Sci
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged allergens Allergies Asthma Asthma - immunology Asthma - microbiology atopy Autoimmune diseases Bacteria Biological and medical sciences Biomarkers Biomedical research Child Child, Preschool childhood Chronic obstructive pulmonary disease, asthma clinical trials cytokines dendritic cells Disease DNA methylation General aspects Grants Humans Immune response Immune system infancy Infant Infant, Newborn Infections inflammation innate immunity interferons Internal Medicine lifestyle Lymphocytes Medical research Medical sciences Metabolites microbiome Middle Aged mucosal immunity Pathogens Patients Pattern recognition people phenotype Pneumology receptors respiratory mucosa Respiratory Mucosa - immunology Respiratory Mucosa - microbiology Skin Young Adult
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