Nucleoside-5'-phosphorothioate analogues are biocompatible antioxidants dissolving efficiently amyloid beta-metal ion aggregates

Amyloid beta (Aβ) peptide is known to precipitate and form aggregates with zinc and copper ions in vitro and, in vivo in Alzheimer's disease (AD) patients. Metal-ion-chelation was suggested as therapy for the metal-ion-induced Aβ aggregation, metal-ion overload, and oxidative stress. In a quest...

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Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2012-07, Vol.41 (28), p.8539-8549
Hauptverfasser:	Amir, Aviran, Shmuel, Eran, Zagalsky, Rostislav, Sayer, Alon H, Nadel, Yael, Fischer, Bilha
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid beta-Peptides - chemistry Antioxidants - chemistry Copper - chemistry Hydrogen Peroxide - chemistry Hydroxyl Radical - chemistry Iron - chemistry Magnetic Resonance Spectroscopy Microscopy, Electron, Transmission Nephelometry and Turbidimetry Thionucleotides - chemistry Zinc - chemistry
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