Effects of Bisphenol S Exposure on Endocrine Functions and Reproduction of Zebrafish
While bisphenol S (BPS) has been frequently detected both in environment and biota, limited information is available on their effects of endocrine system. In the present study, adult zebrafish pairs were exposed to 0.5, 5, and 50 μg/L of BPS for 21 d, and the effects on reproduction, sex steroid hor...
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| Veröffentlicht in: | Environmental science & technology 2013-08, Vol.47 (15), p.8793-8800 |
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| creator | Ji, Kyunghee Hong, Seongjin Kho, Younglim Choi, Kyungho |
| description | While bisphenol S (BPS) has been frequently detected both in environment and biota, limited information is available on their effects of endocrine system. In the present study, adult zebrafish pairs were exposed to 0.5, 5, and 50 μg/L of BPS for 21 d, and the effects on reproduction, sex steroid hormones, and transcription of the genes belonging to the hypothalamic-pituitary-gonad (HPG) axis were investigated. The adverse effects on performances of F1 generation were further examined with or without subsequent exposure to BPS. Egg production and the gonadosomatic index in female fish were significantly decreased at ≥0.5 μg/L BPS. Plasma concentrations of 17β-estradiol were significantly increased in both male and female fish. In male fish, however, significant decreases of testosterone concentration were observed along with up-regulation of cyp19a and down-regulation of cyp17 and 17βhsd transcripts. Parental exposure to BPS resulted in delayed and lesser rates of hatching even when they were hatched in clean water. Continuous BPS exposure in the F1 embryos resulted in worse hatchability and increased malformation rates compared to those without BPS exposure. Our observations showed that exposure to low level BPS could affect the feedback regulatory circuits of HPG axis and impair the development of offspring. |
| doi_str_mv | 10.1021/es400329t |
| format | Article |
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In the present study, adult zebrafish pairs were exposed to 0.5, 5, and 50 μg/L of BPS for 21 d, and the effects on reproduction, sex steroid hormones, and transcription of the genes belonging to the hypothalamic-pituitary-gonad (HPG) axis were investigated. The adverse effects on performances of F1 generation were further examined with or without subsequent exposure to BPS. Egg production and the gonadosomatic index in female fish were significantly decreased at ≥0.5 μg/L BPS. Plasma concentrations of 17β-estradiol were significantly increased in both male and female fish. In male fish, however, significant decreases of testosterone concentration were observed along with up-regulation of cyp19a and down-regulation of cyp17 and 17βhsd transcripts. Parental exposure to BPS resulted in delayed and lesser rates of hatching even when they were hatched in clean water. Continuous BPS exposure in the F1 embryos resulted in worse hatchability and increased malformation rates compared to those without BPS exposure. Our observations showed that exposure to low level BPS could affect the feedback regulatory circuits of HPG axis and impair the development of offspring.</description><identifier>ISSN: 0013-936X</identifier><identifier>EISSN: 1520-5851</identifier><identifier>DOI: 10.1021/es400329t</identifier><identifier>PMID: 23806087</identifier><identifier>CODEN: ESTHAG</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Agnatha. 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Psychology ; Male ; Phenols - toxicity ; Real-Time Polymerase Chain Reaction ; Reproduction - drug effects ; Sulfones - toxicity ; Testosterone ; Zebrafish ; Zebrafish - physiology</subject><ispartof>Environmental science & technology, 2013-08, Vol.47 (15), p.8793-8800</ispartof><rights>Copyright © 2013 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><rights>Copyright American Chemical Society Aug 6, 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a406t-b98dceb108fdebfe32b8cb3fbfb90f462e81ed55fdc17e4540a26156c00ded1b3</citedby><cites>FETCH-LOGICAL-a406t-b98dceb108fdebfe32b8cb3fbfb90f462e81ed55fdc17e4540a26156c00ded1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/es400329t$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/es400329t$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27637686$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23806087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ji, Kyunghee</creatorcontrib><creatorcontrib>Hong, Seongjin</creatorcontrib><creatorcontrib>Kho, Younglim</creatorcontrib><creatorcontrib>Choi, Kyungho</creatorcontrib><title>Effects of Bisphenol S Exposure on Endocrine Functions and Reproduction of Zebrafish</title><title>Environmental science & technology</title><addtitle>Environ. Sci. Technol</addtitle><description>While bisphenol S (BPS) has been frequently detected both in environment and biota, limited information is available on their effects of endocrine system. In the present study, adult zebrafish pairs were exposed to 0.5, 5, and 50 μg/L of BPS for 21 d, and the effects on reproduction, sex steroid hormones, and transcription of the genes belonging to the hypothalamic-pituitary-gonad (HPG) axis were investigated. The adverse effects on performances of F1 generation were further examined with or without subsequent exposure to BPS. Egg production and the gonadosomatic index in female fish were significantly decreased at ≥0.5 μg/L BPS. Plasma concentrations of 17β-estradiol were significantly increased in both male and female fish. In male fish, however, significant decreases of testosterone concentration were observed along with up-regulation of cyp19a and down-regulation of cyp17 and 17βhsd transcripts. Parental exposure to BPS resulted in delayed and lesser rates of hatching even when they were hatched in clean water. Continuous BPS exposure in the F1 embryos resulted in worse hatchability and increased malformation rates compared to those without BPS exposure. Our observations showed that exposure to low level BPS could affect the feedback regulatory circuits of HPG axis and impair the development of offspring.</description><subject>Agnatha. Pisces</subject><subject>Animal reproduction</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Bisphenol A</subject><subject>Danio rerio</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Endocrine Glands - drug effects</subject><subject>Endocrine Glands - physiology</subject><subject>Endocrine system</subject><subject>Female</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Phenols - toxicity</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Reproduction - drug effects</subject><subject>Sulfones - toxicity</subject><subject>Testosterone</subject><subject>Zebrafish</subject><subject>Zebrafish - physiology</subject><issn>0013-936X</issn><issn>1520-5851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0VtrFDEUB_BQlHZb-9AvIIEi1IfRk-tmHrVsVSgIbQXxZcjlhE6ZTbbJDOi3d9aureiLTwfCL-fCn5ATBm8YcPYWqwQQvB33yIIpDo0yij0jCwAmmlborwfksNY7AOACzD454MKABrNckJtVjOjHSnOk7_u6ucWUB3pNV983uU4FaU50lUL2pU9IL6bkxz6nSm0K9Ao3JYfp18v2_zd0xca-3r4gz6MdKh7v6hH5crG6Of_YXH7-8On83WVjJeixca0JHh0DEwO6iII7452ILroWotQcDcOgVAyeLVEqCZZrprQHCBiYE0fk7KHvvMf9hHXs1n31OAw2YZ5qx6RoOZdSm_-gzAitpNnS07_oXZ5Kmg-ZFQehONNiVq8flC-51oKx25R-bcuPjkG3TaV7TGW2L3cdJ7fG8Ch_xzCDVztgq7dDLDb5vj65pRZLbfSTs77-sdU_A38CLFuf3w</recordid><startdate>20130806</startdate><enddate>20130806</enddate><creator>Ji, Kyunghee</creator><creator>Hong, Seongjin</creator><creator>Kho, Younglim</creator><creator>Choi, Kyungho</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope><scope>7QH</scope><scope>7TV</scope><scope>7UA</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>20130806</creationdate><title>Effects of Bisphenol S Exposure on Endocrine Functions and Reproduction of Zebrafish</title><author>Ji, Kyunghee ; Hong, Seongjin ; Kho, Younglim ; Choi, Kyungho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a406t-b98dceb108fdebfe32b8cb3fbfb90f462e81ed55fdc17e4540a26156c00ded1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Agnatha. Pisces</topic><topic>Animal reproduction</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>Bisphenol A</topic><topic>Danio rerio</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>Endocrine Glands - drug effects</topic><topic>Endocrine Glands - physiology</topic><topic>Endocrine system</topic><topic>Female</topic><topic>Freshwater</topic><topic>Fundamental and applied biological sciences. 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Sci. Technol</addtitle><date>2013-08-06</date><risdate>2013</risdate><volume>47</volume><issue>15</issue><spage>8793</spage><epage>8800</epage><pages>8793-8800</pages><issn>0013-936X</issn><eissn>1520-5851</eissn><coden>ESTHAG</coden><abstract>While bisphenol S (BPS) has been frequently detected both in environment and biota, limited information is available on their effects of endocrine system. In the present study, adult zebrafish pairs were exposed to 0.5, 5, and 50 μg/L of BPS for 21 d, and the effects on reproduction, sex steroid hormones, and transcription of the genes belonging to the hypothalamic-pituitary-gonad (HPG) axis were investigated. The adverse effects on performances of F1 generation were further examined with or without subsequent exposure to BPS. Egg production and the gonadosomatic index in female fish were significantly decreased at ≥0.5 μg/L BPS. Plasma concentrations of 17β-estradiol were significantly increased in both male and female fish. In male fish, however, significant decreases of testosterone concentration were observed along with up-regulation of cyp19a and down-regulation of cyp17 and 17βhsd transcripts. Parental exposure to BPS resulted in delayed and lesser rates of hatching even when they were hatched in clean water. Continuous BPS exposure in the F1 embryos resulted in worse hatchability and increased malformation rates compared to those without BPS exposure. Our observations showed that exposure to low level BPS could affect the feedback regulatory circuits of HPG axis and impair the development of offspring.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>23806087</pmid><doi>10.1021/es400329t</doi><tpages>8</tpages></addata></record> |
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| subjects | Agnatha. Pisces Animal reproduction Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Bisphenol A Danio rerio Dose-Response Relationship, Drug Ecotoxicology, biological effects of pollution Effects Effects of pollution and side effects of pesticides on vertebrates Endocrine Glands - drug effects Endocrine Glands - physiology Endocrine system Female Freshwater Fundamental and applied biological sciences. Psychology Male Phenols - toxicity Real-Time Polymerase Chain Reaction Reproduction - drug effects Sulfones - toxicity Testosterone Zebrafish Zebrafish - physiology |
| title | Effects of Bisphenol S Exposure on Endocrine Functions and Reproduction of Zebrafish |
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