VEGF polymorphisms may be associated with susceptibility to colorectal cancer: A case-control study
The vascular endothelial growth factor (VEGF) has a pivotal role in angiogenesis. VEGF levels appear to be influenced by single nucleotide polymorphisms (SNPs) of the VEGF gene. The aim of this study was to assess the importance of four VEGF SNPs in modulating susceptibility to colorectal cancer. We...
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| Veröffentlicht in: | Cancer biomarkers : section A of Disease markers 2011-01, Vol.10 (5), p.213-217 |
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| creator | Antonacopoulou, Anna G. Kottorou, Anastasia E. Dimitrakopoulos, Fotinos-Ioannis D. Triantafyllia, Vasiliki Marousi, Stella Koutras, Angelos Kalofonos, Haralabos P. |
| description | The vascular endothelial growth factor (VEGF) has a pivotal role in angiogenesis. VEGF levels appear to be influenced by single nucleotide polymorphisms (SNPs) of the VEGF gene. The aim of this study was to assess the importance of four VEGF SNPs in modulating susceptibility to colorectal cancer.
We have genotyped 223 patients with colorectal cancer and 264 healthy individuals for the −2578C>A, −1498C>T, −634G>C and +936C>T VEGF SNPs using Taqman probes in polymerase chain reactions.
The −2578 A, −1498 C and −634 G alleles were more frequently detected in CRC patients compared to healthy controls. Moreover, the haplotype −2578C/−1498T was less frequent in CRC patients while the −2578A/−1498C haplotype was significantly more frequent in patients compared to healthy controls.
VEGF −2578C>A and −1498C>T SNPs and −2578/−1498 haplotypes appear to be associated with susceptibility to CRC. |
| doi_str_mv | 10.3233/CBM-2012-0249 |
| format | Article |
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We have genotyped 223 patients with colorectal cancer and 264 healthy individuals for the −2578C>A, −1498C>T, −634G>C and +936C>T VEGF SNPs using Taqman probes in polymerase chain reactions.
The −2578 A, −1498 C and −634 G alleles were more frequently detected in CRC patients compared to healthy controls. Moreover, the haplotype −2578C/−1498T was less frequent in CRC patients while the −2578A/−1498C haplotype was significantly more frequent in patients compared to healthy controls.
VEGF −2578C>A and −1498C>T SNPs and −2578/−1498 haplotypes appear to be associated with susceptibility to CRC.</description><identifier>ISSN: 1574-0153</identifier><identifier>EISSN: 1875-8592</identifier><identifier>DOI: 10.3233/CBM-2012-0249</identifier><identifier>PMID: 22699782</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alleles ; Case-Control Studies ; Colorectal Neoplasms - genetics ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Vascular Endothelial Growth Factor A - genetics</subject><ispartof>Cancer biomarkers : section A of Disease markers, 2011-01, Vol.10 (5), p.213-217</ispartof><rights>IOS Press and the authors. All rights reserved</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-e58e1367d6248c1c37612ee83032656aec06b219393a1cbb80fd00551e233e9a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.3233/CBM-2012-0249$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.3233/CBM-2012-0249$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21945,27830,27901,27902,44921,45309</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.3233/CBM-2012-0249?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22699782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Antonacopoulou, Anna G.</creatorcontrib><creatorcontrib>Kottorou, Anastasia E.</creatorcontrib><creatorcontrib>Dimitrakopoulos, Fotinos-Ioannis D.</creatorcontrib><creatorcontrib>Triantafyllia, Vasiliki</creatorcontrib><creatorcontrib>Marousi, Stella</creatorcontrib><creatorcontrib>Koutras, Angelos</creatorcontrib><creatorcontrib>Kalofonos, Haralabos P.</creatorcontrib><title>VEGF polymorphisms may be associated with susceptibility to colorectal cancer: A case-control study</title><title>Cancer biomarkers : section A of Disease markers</title><addtitle>Cancer Biomark</addtitle><description>The vascular endothelial growth factor (VEGF) has a pivotal role in angiogenesis. VEGF levels appear to be influenced by single nucleotide polymorphisms (SNPs) of the VEGF gene. The aim of this study was to assess the importance of four VEGF SNPs in modulating susceptibility to colorectal cancer.
We have genotyped 223 patients with colorectal cancer and 264 healthy individuals for the −2578C>A, −1498C>T, −634G>C and +936C>T VEGF SNPs using Taqman probes in polymerase chain reactions.
The −2578 A, −1498 C and −634 G alleles were more frequently detected in CRC patients compared to healthy controls. Moreover, the haplotype −2578C/−1498T was less frequent in CRC patients while the −2578A/−1498C haplotype was significantly more frequent in patients compared to healthy controls.
VEGF −2578C>A and −1498C>T SNPs and −2578/−1498 haplotypes appear to be associated with susceptibility to CRC.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Case-Control Studies</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><issn>1574-0153</issn><issn>1875-8592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFP3DAQha2qCLYLx14rHyskF3scJza37Qq2SCAuLdfIcWZLULIOtqMq_x6vlnJDnOYdPj2N3kfIV8F_SJDyYv3zjgEXwDgU5hNZCF0pppWBzzmrqmBcKHlCvsT4xHkhBZhjcgJQGlNpWBD3cLW5pqPv58GH8bGLQ6SDnWmD1MboXWcTtvRflx5pnKLDMXVN13dppslT53sf0CXbU2d3DsMlXeUUkTm_S8H3NKapnU_J0db2Ec9e75L8ub76vf7Fbu83N-vVLXOyFImh0ihkWbUlFNoJJ6tSAKKWXEKpSouOlw0II420wjWN5tuWc6UE5h3QWLkk3w-9Y_DPE8ZUD11-ue_tDv0Ua1FIAyCVFB-jHLgGrYsqo-yAuuBjDLitx9ANNswZqvcK6qyg3iuo9woy_-21emoGbN_o_5tn4PwARPsX6yc_hV1e5Z22F1OAjWk</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Antonacopoulou, Anna G.</creator><creator>Kottorou, Anastasia E.</creator><creator>Dimitrakopoulos, Fotinos-Ioannis D.</creator><creator>Triantafyllia, Vasiliki</creator><creator>Marousi, Stella</creator><creator>Koutras, Angelos</creator><creator>Kalofonos, Haralabos P.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TO</scope><scope>H94</scope></search><sort><creationdate>20110101</creationdate><title>VEGF polymorphisms may be associated with susceptibility to colorectal cancer: A case-control study</title><author>Antonacopoulou, Anna G. ; Kottorou, Anastasia E. ; Dimitrakopoulos, Fotinos-Ioannis D. ; Triantafyllia, Vasiliki ; Marousi, Stella ; Koutras, Angelos ; Kalofonos, Haralabos P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-e58e1367d6248c1c37612ee83032656aec06b219393a1cbb80fd00551e233e9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Case-Control Studies</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Antonacopoulou, Anna G.</creatorcontrib><creatorcontrib>Kottorou, Anastasia E.</creatorcontrib><creatorcontrib>Dimitrakopoulos, Fotinos-Ioannis D.</creatorcontrib><creatorcontrib>Triantafyllia, Vasiliki</creatorcontrib><creatorcontrib>Marousi, Stella</creatorcontrib><creatorcontrib>Koutras, Angelos</creatorcontrib><creatorcontrib>Kalofonos, Haralabos P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Cancer biomarkers : section A of Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Antonacopoulou, Anna G.</au><au>Kottorou, Anastasia E.</au><au>Dimitrakopoulos, Fotinos-Ioannis D.</au><au>Triantafyllia, Vasiliki</au><au>Marousi, Stella</au><au>Koutras, Angelos</au><au>Kalofonos, Haralabos P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>VEGF polymorphisms may be associated with susceptibility to colorectal cancer: A case-control study</atitle><jtitle>Cancer biomarkers : section A of Disease markers</jtitle><addtitle>Cancer Biomark</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>10</volume><issue>5</issue><spage>213</spage><epage>217</epage><pages>213-217</pages><issn>1574-0153</issn><eissn>1875-8592</eissn><abstract>The vascular endothelial growth factor (VEGF) has a pivotal role in angiogenesis. VEGF levels appear to be influenced by single nucleotide polymorphisms (SNPs) of the VEGF gene. The aim of this study was to assess the importance of four VEGF SNPs in modulating susceptibility to colorectal cancer.
We have genotyped 223 patients with colorectal cancer and 264 healthy individuals for the −2578C>A, −1498C>T, −634G>C and +936C>T VEGF SNPs using Taqman probes in polymerase chain reactions.
The −2578 A, −1498 C and −634 G alleles were more frequently detected in CRC patients compared to healthy controls. Moreover, the haplotype −2578C/−1498T was less frequent in CRC patients while the −2578A/−1498C haplotype was significantly more frequent in patients compared to healthy controls.
VEGF −2578C>A and −1498C>T SNPs and −2578/−1498 haplotypes appear to be associated with susceptibility to CRC.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>22699782</pmid><doi>10.3233/CBM-2012-0249</doi><tpages>5</tpages></addata></record> |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Adult Aged Aged, 80 and over Alleles Case-Control Studies Colorectal Neoplasms - genetics Female Gene Frequency Genetic Predisposition to Disease Haplotypes Humans Male Middle Aged Polymorphism, Single Nucleotide Vascular Endothelial Growth Factor A - genetics |
| title | VEGF polymorphisms may be associated with susceptibility to colorectal cancer: A case-control study |
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