Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy

Thalidomide and its analogues (lenalidomide and pomalidomide) are small molecule glutamic acid derivatives of the immunomodulatory drug (IMiD) class. In addition to the immuno-adjuvant and anti-inflammatory properties that define an IMiD, the thalidomide analogues demonstrate an overlapping and dive...

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Veröffentlicht in:	Oncogene 2013-09, Vol.32 (36), p.4191-4202
Hauptverfasser:	Shortt, J, Hsu, A K, Johnstone, R W
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/2325 631/92/609 692/420/2489/2487/2486 692/699/67/1990 Analysis Angiogenesis Animals Anti-inflammatory agents Antineoplastic Agents - adverse effects Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Antitumor activity Apoptosis Blood diseases Cancer Cancer therapies Care and treatment Cell Biology Chromosome 5 Chromosome Deletion Chromosomes, Human, Pair 5 Drug development Drug targeting Epigenesis, Genetic - drug effects Epigenetics Glutamic acid Human Genetics Humans Immune system Immunologic Factors - adverse effects Immunologic Factors - chemistry Immunologic Factors - therapeutic use Immunomodulation Immunomodulation - drug effects Inflammation Internal Medicine Lymphocytes B Medicine Medicine & Public Health Molecular biology Multiple Myeloma - drug therapy Myelodysplastic syndrome Myelodysplastic Syndromes - drug therapy Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - immunology Neoplasia Neoplasms - drug therapy Neoplasms - genetics Neoplasms - immunology Oncology review Teratogenicity Testing Thalidomide Thalidomide - adverse effects Thalidomide - analogs & derivatives Thalidomide - chemistry Thalidomide - therapeutic use Toxicity
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