Metabolically functional hepatocyte-like cells from human umbilical cord lining epithelial cells

The primary hepatocyte is the best benchmark for drug biotransformation studies. However, due to the severe shortage of primary hepatocytes, there is a need for alternative reliable cell source. This study aims to isolate multipotent epithelial cells from the umbilical cord, differentiate these cell...

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Veröffentlicht in:	Assay and drug development technologies 2013-03, Vol.11 (2), p.130-138
Hauptverfasser:	Cheong, Han Hui, Masilamani, Jeyakumar, Chan, Chun Yong Eric, Chan, Sui Yung, Phan, Toan Thang
Format:	Artikel
Sprache:	eng
Schlagworte:	Batch Cell Culture Techniques - methods Cell Differentiation Cell Proliferation Cells, Cultured Epithelial Cells - cytology Epithelial Cells - metabolism Female Hepatocytes - cytology Hepatocytes - metabolism Humans Multipotent Stem Cells - cytology Multipotent Stem Cells - physiology Proteome - metabolism Umbilical Cord - cytology Umbilical Cord - physiology
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