Dynamic color-coded fluorescence imaging of the cell-cycle phase, mitosis, and apoptosis demonstrates how caffeine modulates cisplatinum efficacy

ABSTRACT Caffeine enhances the effect of certain anticancer drugs, but the mechanism of modulation is poorly understood. In this study, modulation of cisplatinum efficacy induced by caffeine was visualized at the subcellular level by real‐time fluorescent‐protein imaging. Mitotic and apoptotic chang...

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Veröffentlicht in:	Journal of cellular biochemistry 2013-11, Vol.114 (11), p.2454-2460
Hauptverfasser:	Miwa, Shinji, Yano, Shuya, Tome, Yasunori, Sugimoto, Naotoshi, Hiroshima, Yukihiko, Uehara, Fuminari, Mii, Sumiyuki, Kimura, Hiroaki, Hayashi, Katsuhiro, Efimova, Elena V., Fujiwara, Toshiyoshi, Tsuchiya, Hiroyuki, Hoffman, Robert M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor agents APOPTOSIS Apoptosis - drug effects CAFFEINE Caffeine - pharmacology CELL CYCLE Cell Cycle - drug effects Cell Line, Tumor Cisplatin - pharmacology CISPLATINUM DNA Damage - drug effects Drug Interactions FLUORESCENCE IMAGING FUCCI GFP Humans Microscopy, Confocal MITOSIS Mitosis - drug effects MODULATION OSTEOSARCOMA RFP
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