PKCδ-mediated phosphorylation of BAG3 at Ser187 site induces epithelial−mesenchymal transition and enhances invasiveness in thyroid cancer FRO cells

Protein kinase C delta (PKCδ) is a serine (Ser)/threonine kinase, which regulates numerous cellular processes, including proliferation, differentiation, migration and apoptosis. In the current study, Chinese hamster ovary cells were transfected with either a constitutively activated PKCδ or a domina...

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Veröffentlicht in:	Oncogene 2013-09, Vol.32 (38), p.4539-4548
Hauptverfasser:	Li, N, Du, Z-X, Zong, Z-H, Liu, B-Q, Li, C, Zhang, Q, Wang, H-Q
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1459/1843 631/80/458/1733 631/80/84/2176 631/80/84/2336 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis Apoptosis Regulatory Proteins Bcl-2 protein Cancer cells Cell Biology Cell Line, Tumor Cell Movement - genetics CHO Cells Cricetulus Cytology Development and progression Epithelial-Mesenchymal Transition - genetics Gel electrophoresis Human Genetics Humans Internal Medicine Invasiveness Kinases Mass spectroscopy Medicine Medicine & Public Health Mesenchyme Oncology original-article Phosphorylation Physiological aspects Protein Binding Protein kinase C Protein Kinase C-delta - genetics Protein Kinase C-delta - metabolism Protein kinases Protein-serine/threonine kinase Serine - metabolism Thyroid cancer Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology
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