Markers of HPV infection and survival in patients with head and neck tumors

The purpose of this study was to determine whether changes in human papillomavirus (HPV) DNA prevalence in oral rinses and/or HPV‐specific antibody levels in the sera of patients with oral/oropharyngeal cancer have prognostic significance. One hundred and forty‐two patients with oral/oropharyngeal t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International journal of cancer 2013-10, Vol.133 (8), p.1832-1839
Hauptverfasser: Koslabova, Eva, Hamsikova, Eva, Salakova, Martina, Klozar, Jan, Foltynova, Eva, Salkova, Eva, Rotnaglova, Eliska, Ludvikova, Viera, Tachezy, Ruth
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1839
container_issue 8
container_start_page 1832
container_title International journal of cancer
container_volume 133
creator Koslabova, Eva
Hamsikova, Eva
Salakova, Martina
Klozar, Jan
Foltynova, Eva
Salkova, Eva
Rotnaglova, Eliska
Ludvikova, Viera
Tachezy, Ruth
description The purpose of this study was to determine whether changes in human papillomavirus (HPV) DNA prevalence in oral rinses and/or HPV‐specific antibody levels in the sera of patients with oral/oropharyngeal cancer have prognostic significance. One hundred and forty‐two patients with oral/oropharyngeal tumors were enrolled. The presence of HPV DNA was assayed in tumor tissue and oral rinses and HPV‐specific antibodies were assessed in the sera. Oral rinses were collected before treatment and one year after the treatment. Sera were drawn before treatment, one month, and one year after the end of the treatment. Altogether, 59.2% of tumors were HPV positive. The presence of HPV DNA in the tumors correlated with HPV DNA positivity in oral rinses and with HPV‐specific antibodies in the sera. Out of 66 patients with HPV‐positive oral rinses at enrolment, 84.8% became negative at one‐year follow‐up, while most patients remained seropositive for HPV‐specific antigens. However, the mean titers of HPV16 E6 and/or E7 antibodies at follow‐up were significantly lower. Of 16 patients with recurrences at follow‐up (alive on second sampling), six were positive at enrolment for HPV16 E6 and/or E7 antibodies. In five of these, no decrease in antibody levels was observed. Titers of antibodies specific for HPV16 capsid antigens did not change during the follow‐up. Our data suggest that the detection of antibodies specific for the HPV 16 E6 and E7 oncoproteins may serve not only as a marker of HPV etiology, but also as a marker of recurrence and a prognostic indicator in patients with HPV‐positive tumors. What's new? Do changes in the amount of HPV DNA detected orally indicate whether cancer will recur? In this paper, the authors collected oral rinses from 142 patients before and after treatment. They found that the presence of HPV in the oral rinse correlated with HPV DNA detected in the tumor tissues, but that by one year after treatment, the oral rinse usually came back negative for HPV despite the continuing presence of HPV in the tumor cells. On the other hand, the authors did find that lingering HPV antibodies in the bloodstream seemed to correlate with tumor recurrence, suggesting that antibody testing could be a good prognostic indicator in patients with HPV‐positive tumors.
doi_str_mv 10.1002/ijc.28194
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1439216753</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1420166987</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3824-19880625d9836e996c2255f494cf68597a38c211c4b6e02e19380447c1a01a5c3</originalsourceid><addsrcrecordid>eNqN0UtLAzEQB_Agiq2Pg19AAiJ42ZrJO0cpvhU9qNclplmadrtbk92K395trQqePGXI_BiY-SN0AGQAhNDTMHEDqsHwDdQHYlRGKIhN1O96JFPAZA_tpDQhBEAQvo16lAnJGYU-ur23cepjwnWBrx5fcKgK75pQV9hWI5zauAgLW3bfeG6b4Ksm4ffQjPHY29GKVN5NcdPO6pj20FZhy-T31-8uer44fxpeZXcPl9fDs7vMMU15BkZrIqkYGc2kN0Y6SoUouOGukFoYZZl2FMDxV-kJ9WCYJpwrB5aAFY7topOvufNYv7U-NfksJOfL0la-blMOnBkKUgn2D0oJSGm06ujRHzqp21h1iyyV0lJxKjt1uFbt68yP8nkMMxs_8u-LduB4DWxytiyirVxIv05JKg1ZDjr9cu-h9B8_fSD5MtK8izRfRZpf3wxXBfsEHVKOTg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1427867426</pqid></control><display><type>article</type><title>Markers of HPV infection and survival in patients with head and neck tumors</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Koslabova, Eva ; Hamsikova, Eva ; Salakova, Martina ; Klozar, Jan ; Foltynova, Eva ; Salkova, Eva ; Rotnaglova, Eliska ; Ludvikova, Viera ; Tachezy, Ruth</creator><creatorcontrib>Koslabova, Eva ; Hamsikova, Eva ; Salakova, Martina ; Klozar, Jan ; Foltynova, Eva ; Salkova, Eva ; Rotnaglova, Eliska ; Ludvikova, Viera ; Tachezy, Ruth</creatorcontrib><description>The purpose of this study was to determine whether changes in human papillomavirus (HPV) DNA prevalence in oral rinses and/or HPV‐specific antibody levels in the sera of patients with oral/oropharyngeal cancer have prognostic significance. One hundred and forty‐two patients with oral/oropharyngeal tumors were enrolled. The presence of HPV DNA was assayed in tumor tissue and oral rinses and HPV‐specific antibodies were assessed in the sera. Oral rinses were collected before treatment and one year after the treatment. Sera were drawn before treatment, one month, and one year after the end of the treatment. Altogether, 59.2% of tumors were HPV positive. The presence of HPV DNA in the tumors correlated with HPV DNA positivity in oral rinses and with HPV‐specific antibodies in the sera. Out of 66 patients with HPV‐positive oral rinses at enrolment, 84.8% became negative at one‐year follow‐up, while most patients remained seropositive for HPV‐specific antigens. However, the mean titers of HPV16 E6 and/or E7 antibodies at follow‐up were significantly lower. Of 16 patients with recurrences at follow‐up (alive on second sampling), six were positive at enrolment for HPV16 E6 and/or E7 antibodies. In five of these, no decrease in antibody levels was observed. Titers of antibodies specific for HPV16 capsid antigens did not change during the follow‐up. Our data suggest that the detection of antibodies specific for the HPV 16 E6 and E7 oncoproteins may serve not only as a marker of HPV etiology, but also as a marker of recurrence and a prognostic indicator in patients with HPV‐positive tumors. What's new? Do changes in the amount of HPV DNA detected orally indicate whether cancer will recur? In this paper, the authors collected oral rinses from 142 patients before and after treatment. They found that the presence of HPV in the oral rinse correlated with HPV DNA detected in the tumor tissues, but that by one year after treatment, the oral rinse usually came back negative for HPV despite the continuing presence of HPV in the tumor cells. On the other hand, the authors did find that lingering HPV antibodies in the bloodstream seemed to correlate with tumor recurrence, suggesting that antibody testing could be a good prognostic indicator in patients with HPV‐positive tumors.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.28194</identifier><identifier>PMID: 23564321</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>Hoboken, NJ: Wiley-Blackwell</publisher><subject>antibodies ; Antibodies, Viral - blood ; Biological and medical sciences ; Biomarkers, Tumor ; Cancer ; Capsid Proteins - immunology ; Cervical cancer ; Deoxyribonucleic acid ; DNA ; DNA, Viral - isolation &amp; purification ; Female ; follow‐up ; head and neck cancer ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - virology ; HPV ; Human papillomavirus ; Human papillomavirus 16 ; Human papillomavirus 16 - immunology ; Humans ; Male ; Medical research ; Medical sciences ; Middle Aged ; Mouth - virology ; Oncogene Proteins, Viral - immunology ; oral rinses ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Papillomavirus E7 Proteins - immunology ; Papillomavirus Infections - blood ; Papillomavirus Infections - genetics ; Papillomavirus Infections - immunology ; Prognosis ; Repressor Proteins - immunology ; Survival Rate ; Tumors</subject><ispartof>International journal of cancer, 2013-10, Vol.133 (8), p.1832-1839</ispartof><rights>Copyright © 2013 UICC</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 UICC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3824-19880625d9836e996c2255f494cf68597a38c211c4b6e02e19380447c1a01a5c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.28194$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.28194$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=27626906$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23564321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koslabova, Eva</creatorcontrib><creatorcontrib>Hamsikova, Eva</creatorcontrib><creatorcontrib>Salakova, Martina</creatorcontrib><creatorcontrib>Klozar, Jan</creatorcontrib><creatorcontrib>Foltynova, Eva</creatorcontrib><creatorcontrib>Salkova, Eva</creatorcontrib><creatorcontrib>Rotnaglova, Eliska</creatorcontrib><creatorcontrib>Ludvikova, Viera</creatorcontrib><creatorcontrib>Tachezy, Ruth</creatorcontrib><title>Markers of HPV infection and survival in patients with head and neck tumors</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>The purpose of this study was to determine whether changes in human papillomavirus (HPV) DNA prevalence in oral rinses and/or HPV‐specific antibody levels in the sera of patients with oral/oropharyngeal cancer have prognostic significance. One hundred and forty‐two patients with oral/oropharyngeal tumors were enrolled. The presence of HPV DNA was assayed in tumor tissue and oral rinses and HPV‐specific antibodies were assessed in the sera. Oral rinses were collected before treatment and one year after the treatment. Sera were drawn before treatment, one month, and one year after the end of the treatment. Altogether, 59.2% of tumors were HPV positive. The presence of HPV DNA in the tumors correlated with HPV DNA positivity in oral rinses and with HPV‐specific antibodies in the sera. Out of 66 patients with HPV‐positive oral rinses at enrolment, 84.8% became negative at one‐year follow‐up, while most patients remained seropositive for HPV‐specific antigens. However, the mean titers of HPV16 E6 and/or E7 antibodies at follow‐up were significantly lower. Of 16 patients with recurrences at follow‐up (alive on second sampling), six were positive at enrolment for HPV16 E6 and/or E7 antibodies. In five of these, no decrease in antibody levels was observed. Titers of antibodies specific for HPV16 capsid antigens did not change during the follow‐up. Our data suggest that the detection of antibodies specific for the HPV 16 E6 and E7 oncoproteins may serve not only as a marker of HPV etiology, but also as a marker of recurrence and a prognostic indicator in patients with HPV‐positive tumors. What's new? Do changes in the amount of HPV DNA detected orally indicate whether cancer will recur? In this paper, the authors collected oral rinses from 142 patients before and after treatment. They found that the presence of HPV in the oral rinse correlated with HPV DNA detected in the tumor tissues, but that by one year after treatment, the oral rinse usually came back negative for HPV despite the continuing presence of HPV in the tumor cells. On the other hand, the authors did find that lingering HPV antibodies in the bloodstream seemed to correlate with tumor recurrence, suggesting that antibody testing could be a good prognostic indicator in patients with HPV‐positive tumors.</description><subject>antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor</subject><subject>Cancer</subject><subject>Capsid Proteins - immunology</subject><subject>Cervical cancer</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA, Viral - isolation &amp; purification</subject><subject>Female</subject><subject>follow‐up</subject><subject>head and neck cancer</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - virology</subject><subject>HPV</subject><subject>Human papillomavirus</subject><subject>Human papillomavirus 16</subject><subject>Human papillomavirus 16 - immunology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mouth - virology</subject><subject>Oncogene Proteins, Viral - immunology</subject><subject>oral rinses</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Papillomavirus E7 Proteins - immunology</subject><subject>Papillomavirus Infections - blood</subject><subject>Papillomavirus Infections - genetics</subject><subject>Papillomavirus Infections - immunology</subject><subject>Prognosis</subject><subject>Repressor Proteins - immunology</subject><subject>Survival Rate</subject><subject>Tumors</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0UtLAzEQB_Agiq2Pg19AAiJ42ZrJO0cpvhU9qNclplmadrtbk92K395trQqePGXI_BiY-SN0AGQAhNDTMHEDqsHwDdQHYlRGKIhN1O96JFPAZA_tpDQhBEAQvo16lAnJGYU-ur23cepjwnWBrx5fcKgK75pQV9hWI5zauAgLW3bfeG6b4Ksm4ffQjPHY29GKVN5NcdPO6pj20FZhy-T31-8uer44fxpeZXcPl9fDs7vMMU15BkZrIqkYGc2kN0Y6SoUouOGukFoYZZl2FMDxV-kJ9WCYJpwrB5aAFY7topOvufNYv7U-NfksJOfL0la-blMOnBkKUgn2D0oJSGm06ujRHzqp21h1iyyV0lJxKjt1uFbt68yP8nkMMxs_8u-LduB4DWxytiyirVxIv05JKg1ZDjr9cu-h9B8_fSD5MtK8izRfRZpf3wxXBfsEHVKOTg</recordid><startdate>20131015</startdate><enddate>20131015</enddate><creator>Koslabova, Eva</creator><creator>Hamsikova, Eva</creator><creator>Salakova, Martina</creator><creator>Klozar, Jan</creator><creator>Foltynova, Eva</creator><creator>Salkova, Eva</creator><creator>Rotnaglova, Eliska</creator><creator>Ludvikova, Viera</creator><creator>Tachezy, Ruth</creator><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20131015</creationdate><title>Markers of HPV infection and survival in patients with head and neck tumors</title><author>Koslabova, Eva ; Hamsikova, Eva ; Salakova, Martina ; Klozar, Jan ; Foltynova, Eva ; Salkova, Eva ; Rotnaglova, Eliska ; Ludvikova, Viera ; Tachezy, Ruth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3824-19880625d9836e996c2255f494cf68597a38c211c4b6e02e19380447c1a01a5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>antibodies</topic><topic>Antibodies, Viral - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor</topic><topic>Cancer</topic><topic>Capsid Proteins - immunology</topic><topic>Cervical cancer</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA, Viral - isolation &amp; purification</topic><topic>Female</topic><topic>follow‐up</topic><topic>head and neck cancer</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - virology</topic><topic>HPV</topic><topic>Human papillomavirus</topic><topic>Human papillomavirus 16</topic><topic>Human papillomavirus 16 - immunology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mouth - virology</topic><topic>Oncogene Proteins, Viral - immunology</topic><topic>oral rinses</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Papillomavirus E7 Proteins - immunology</topic><topic>Papillomavirus Infections - blood</topic><topic>Papillomavirus Infections - genetics</topic><topic>Papillomavirus Infections - immunology</topic><topic>Prognosis</topic><topic>Repressor Proteins - immunology</topic><topic>Survival Rate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koslabova, Eva</creatorcontrib><creatorcontrib>Hamsikova, Eva</creatorcontrib><creatorcontrib>Salakova, Martina</creatorcontrib><creatorcontrib>Klozar, Jan</creatorcontrib><creatorcontrib>Foltynova, Eva</creatorcontrib><creatorcontrib>Salkova, Eva</creatorcontrib><creatorcontrib>Rotnaglova, Eliska</creatorcontrib><creatorcontrib>Ludvikova, Viera</creatorcontrib><creatorcontrib>Tachezy, Ruth</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koslabova, Eva</au><au>Hamsikova, Eva</au><au>Salakova, Martina</au><au>Klozar, Jan</au><au>Foltynova, Eva</au><au>Salkova, Eva</au><au>Rotnaglova, Eliska</au><au>Ludvikova, Viera</au><au>Tachezy, Ruth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Markers of HPV infection and survival in patients with head and neck tumors</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2013-10-15</date><risdate>2013</risdate><volume>133</volume><issue>8</issue><spage>1832</spage><epage>1839</epage><pages>1832-1839</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>The purpose of this study was to determine whether changes in human papillomavirus (HPV) DNA prevalence in oral rinses and/or HPV‐specific antibody levels in the sera of patients with oral/oropharyngeal cancer have prognostic significance. One hundred and forty‐two patients with oral/oropharyngeal tumors were enrolled. The presence of HPV DNA was assayed in tumor tissue and oral rinses and HPV‐specific antibodies were assessed in the sera. Oral rinses were collected before treatment and one year after the treatment. Sera were drawn before treatment, one month, and one year after the end of the treatment. Altogether, 59.2% of tumors were HPV positive. The presence of HPV DNA in the tumors correlated with HPV DNA positivity in oral rinses and with HPV‐specific antibodies in the sera. Out of 66 patients with HPV‐positive oral rinses at enrolment, 84.8% became negative at one‐year follow‐up, while most patients remained seropositive for HPV‐specific antigens. However, the mean titers of HPV16 E6 and/or E7 antibodies at follow‐up were significantly lower. Of 16 patients with recurrences at follow‐up (alive on second sampling), six were positive at enrolment for HPV16 E6 and/or E7 antibodies. In five of these, no decrease in antibody levels was observed. Titers of antibodies specific for HPV16 capsid antigens did not change during the follow‐up. Our data suggest that the detection of antibodies specific for the HPV 16 E6 and E7 oncoproteins may serve not only as a marker of HPV etiology, but also as a marker of recurrence and a prognostic indicator in patients with HPV‐positive tumors. What's new? Do changes in the amount of HPV DNA detected orally indicate whether cancer will recur? In this paper, the authors collected oral rinses from 142 patients before and after treatment. They found that the presence of HPV in the oral rinse correlated with HPV DNA detected in the tumor tissues, but that by one year after treatment, the oral rinse usually came back negative for HPV despite the continuing presence of HPV in the tumor cells. On the other hand, the authors did find that lingering HPV antibodies in the bloodstream seemed to correlate with tumor recurrence, suggesting that antibody testing could be a good prognostic indicator in patients with HPV‐positive tumors.</abstract><cop>Hoboken, NJ</cop><pub>Wiley-Blackwell</pub><pmid>23564321</pmid><doi>10.1002/ijc.28194</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0020-7136
ispartof International journal of cancer, 2013-10, Vol.133 (8), p.1832-1839
issn 0020-7136
1097-0215
language eng
recordid cdi_proquest_miscellaneous_1439216753
source MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals
subjects antibodies
Antibodies, Viral - blood
Biological and medical sciences
Biomarkers, Tumor
Cancer
Capsid Proteins - immunology
Cervical cancer
Deoxyribonucleic acid
DNA
DNA, Viral - isolation & purification
Female
follow‐up
head and neck cancer
Head and Neck Neoplasms - mortality
Head and Neck Neoplasms - virology
HPV
Human papillomavirus
Human papillomavirus 16
Human papillomavirus 16 - immunology
Humans
Male
Medical research
Medical sciences
Middle Aged
Mouth - virology
Oncogene Proteins, Viral - immunology
oral rinses
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Papillomavirus E7 Proteins - immunology
Papillomavirus Infections - blood
Papillomavirus Infections - genetics
Papillomavirus Infections - immunology
Prognosis
Repressor Proteins - immunology
Survival Rate
Tumors
title Markers of HPV infection and survival in patients with head and neck tumors
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T17%3A45%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Markers%20of%20HPV%20infection%20and%20survival%20in%20patients%20with%20head%20and%20neck%20tumors&rft.jtitle=International%20journal%20of%20cancer&rft.au=Koslabova,%20Eva&rft.date=2013-10-15&rft.volume=133&rft.issue=8&rft.spage=1832&rft.epage=1839&rft.pages=1832-1839&rft.issn=0020-7136&rft.eissn=1097-0215&rft.coden=IJCNAW&rft_id=info:doi/10.1002/ijc.28194&rft_dat=%3Cproquest_pubme%3E1420166987%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1427867426&rft_id=info:pmid/23564321&rfr_iscdi=true