Potential of Nonoral α-Lipoic Acid Aqueous Formulations to Reduce Ocular Microvascular Complications in a Streptozotocin-Induced Diabetic Rat Model

α-Lipoic acid (LA) aqueous formulations were studied for nonoral administration, including intravitreal and intraperitoneal preparations and topical eyedrops. The potential retinoprotective effects of these LA preparations were also evaluated in streptozotocin (STZ)-induced diabetic rats for screeni...

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Veröffentlicht in:	Journal of ocular pharmacology and therapeutics 2013-10, Vol.29 (8), p.738-745
Hauptverfasser:	CHEN, Chen-Ling, CHENG, Wen-Sheng, CHEN, Jiin-Long, CHIANG, Chiao-Hsi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Ophthalmic Animals Antioxidants - administration & dosage Antioxidants - chemistry Antioxidants - therapeutic use Biological and medical sciences Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - pathology Diabetes. Impaired glucose tolerance Diabetic Retinopathy - pathology Diabetic Retinopathy - prevention & control Drug Stability Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Injections, Intraperitoneal Intravitreal Injections Male Medical sciences Microvessels - drug effects Microvessels - pathology Pharmacology. Drug treatments Rats Rats, Wistar Thioctic Acid - administration & dosage Thioctic Acid - chemistry Thioctic Acid - therapeutic use
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