Meta-analysis of confocal laser endomicroscopy for the detection of colorectal neoplasia
Aim Confocal laser endomicroscopy (CLE) is a recently developed technique used to image colorectal neoplasia. Trials have shown varied results when it is compared with conventional colonoscopy. A meta‐analysis was performed to determine the diagnostic accuracy of CLE in the detection of colorectal n...
Gespeichert in:
Veröffentlicht in: | Colorectal disease 2013-09, Vol.15 (9), p.e488-e495 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | e495 |
---|---|
container_issue | 9 |
container_start_page | e488 |
container_title | Colorectal disease |
container_volume | 15 |
creator | Dong, Y.-Y. Li, Y.-Q. Yu, Y.-B. Liu, J. Li, M. Luan, X.-R. |
description | Aim
Confocal laser endomicroscopy (CLE) is a recently developed technique used to image colorectal neoplasia. Trials have shown varied results when it is compared with conventional colonoscopy. A meta‐analysis was performed to determine the diagnostic accuracy of CLE in the detection of colorectal neoplasia.
Method
A search was performed for studies assessing the accuracy of CLE in colorectal neoplasia. Studies comparing CLE diagnostic accuracy with conventional endoscopy in the detection of colorectal neoplasia were included. Exclusion criteria included case reports or case series, reviews, duplicate reports or insufficient data in the paper. Seventy‐eight titles came up in the initial search and six studies were selected. These were subjected to a meta‐analysis. In all, 284 patients with 1030 lesions were included. Each patient underwent conventional colonoscopy and CLE. Per‐lesion sensitivity and specificity with 95% CI were calculated.
Results
In the individual studies, the sensitivity ranged from 33.3% to 100% and specificity from 71.6% to 99.4%. The weighted and total pooled result (random effects model) for sensitivity was 81% (95% CI 77–85) and for specificity was 88% (95% CI 85–90). The area under the weighted symmetric summary receiver operating curve was 0.9186. In the endoscope‐based CLE subgroup, the sensitivity was 82% (95% CI 69–91) and specificity was 94% (95% CI 91–96). In the probe‐based CLE subgroup, the sensitivity was 81% (95% CI 76–85) and the specificity was 75% (95% CI 69–81).
Conclusion
CLE, using either the endoscope‐based CLE or probe‐based CLE technique, has high sensitivity and specificity. It could therefore be considered as an alternative endoscopic method to distinguish neoplastic from non‐neoplastic lesions. |
doi_str_mv | 10.1111/codi.12329 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1438572330</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1438572330</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3679-6ce8f56c58ab7249799a815dde66cf7a0a338a6712cd2c0ee7d6fdd56aee88103</originalsourceid><addsrcrecordid>eNp9kMtOAyEUhonRaL1sfAAzS2MyyqUDzNLUe2q7qZe4IQhnIjodKkyjfXtpR7uUDZB8359zfoQOCT4l6ZwZb90poYyWG6hH-pzlhBG5uXrTXJYE76DdGN8xJlwQuY12KJMEE1z00PM9tDrXja4X0cXMV5nxTeWNrrNaRwgZNNZPnQk-Gj9bZJUPWfsGmYUWTOt80ym1D-mbpAb8LIlO76OtStcRDn7vPfRwdTkZ3OTD8fXt4HyYG8ZFmXMDsiq4KaR-FbRfirLUkhTWAuemEhprxqROY1NjqcEAwvLK2oJrAJmWYHvouMudBf85h9iqqYsG6lqnUeZRkT6ThaCMLdGTDl1uEwNUahbcVIeFIlgtm1TLJtWqyQQf_ebOX6dg1-hfdQkgHfDlalj8E6UG44vbv9C8c1xs4Xvt6PChuGCiUE-ja_XSf5zQOzZSQ_YDdqaOcg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1438572330</pqid></control><display><type>article</type><title>Meta-analysis of confocal laser endomicroscopy for the detection of colorectal neoplasia</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Dong, Y.-Y. ; Li, Y.-Q. ; Yu, Y.-B. ; Liu, J. ; Li, M. ; Luan, X.-R.</creator><creatorcontrib>Dong, Y.-Y. ; Li, Y.-Q. ; Yu, Y.-B. ; Liu, J. ; Li, M. ; Luan, X.-R.</creatorcontrib><description>Aim
Confocal laser endomicroscopy (CLE) is a recently developed technique used to image colorectal neoplasia. Trials have shown varied results when it is compared with conventional colonoscopy. A meta‐analysis was performed to determine the diagnostic accuracy of CLE in the detection of colorectal neoplasia.
Method
A search was performed for studies assessing the accuracy of CLE in colorectal neoplasia. Studies comparing CLE diagnostic accuracy with conventional endoscopy in the detection of colorectal neoplasia were included. Exclusion criteria included case reports or case series, reviews, duplicate reports or insufficient data in the paper. Seventy‐eight titles came up in the initial search and six studies were selected. These were subjected to a meta‐analysis. In all, 284 patients with 1030 lesions were included. Each patient underwent conventional colonoscopy and CLE. Per‐lesion sensitivity and specificity with 95% CI were calculated.
Results
In the individual studies, the sensitivity ranged from 33.3% to 100% and specificity from 71.6% to 99.4%. The weighted and total pooled result (random effects model) for sensitivity was 81% (95% CI 77–85) and for specificity was 88% (95% CI 85–90). The area under the weighted symmetric summary receiver operating curve was 0.9186. In the endoscope‐based CLE subgroup, the sensitivity was 82% (95% CI 69–91) and specificity was 94% (95% CI 91–96). In the probe‐based CLE subgroup, the sensitivity was 81% (95% CI 76–85) and the specificity was 75% (95% CI 69–81).
Conclusion
CLE, using either the endoscope‐based CLE or probe‐based CLE technique, has high sensitivity and specificity. It could therefore be considered as an alternative endoscopic method to distinguish neoplastic from non‐neoplastic lesions.</description><identifier>ISSN: 1462-8910</identifier><identifier>EISSN: 1463-1318</identifier><identifier>DOI: 10.1111/codi.12329</identifier><identifier>PMID: 23810105</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - pathology ; Adenoma - diagnosis ; Adenoma - pathology ; Colonoscopy - methods ; colorectal neoplasia ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - pathology ; confocal endomicroscopy ; Confocal laser endomicroscopy ; Early Detection of Cancer - methods ; endoscopy ; Humans ; meta-analysis ; Microscopy, Confocal - methods ; Sensitivity and Specificity</subject><ispartof>Colorectal disease, 2013-09, Vol.15 (9), p.e488-e495</ispartof><rights>Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland</rights><rights>Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3679-6ce8f56c58ab7249799a815dde66cf7a0a338a6712cd2c0ee7d6fdd56aee88103</citedby><cites>FETCH-LOGICAL-c3679-6ce8f56c58ab7249799a815dde66cf7a0a338a6712cd2c0ee7d6fdd56aee88103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcodi.12329$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcodi.12329$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23810105$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dong, Y.-Y.</creatorcontrib><creatorcontrib>Li, Y.-Q.</creatorcontrib><creatorcontrib>Yu, Y.-B.</creatorcontrib><creatorcontrib>Liu, J.</creatorcontrib><creatorcontrib>Li, M.</creatorcontrib><creatorcontrib>Luan, X.-R.</creatorcontrib><title>Meta-analysis of confocal laser endomicroscopy for the detection of colorectal neoplasia</title><title>Colorectal disease</title><addtitle>Colorectal Dis</addtitle><description>Aim
Confocal laser endomicroscopy (CLE) is a recently developed technique used to image colorectal neoplasia. Trials have shown varied results when it is compared with conventional colonoscopy. A meta‐analysis was performed to determine the diagnostic accuracy of CLE in the detection of colorectal neoplasia.
Method
A search was performed for studies assessing the accuracy of CLE in colorectal neoplasia. Studies comparing CLE diagnostic accuracy with conventional endoscopy in the detection of colorectal neoplasia were included. Exclusion criteria included case reports or case series, reviews, duplicate reports or insufficient data in the paper. Seventy‐eight titles came up in the initial search and six studies were selected. These were subjected to a meta‐analysis. In all, 284 patients with 1030 lesions were included. Each patient underwent conventional colonoscopy and CLE. Per‐lesion sensitivity and specificity with 95% CI were calculated.
Results
In the individual studies, the sensitivity ranged from 33.3% to 100% and specificity from 71.6% to 99.4%. The weighted and total pooled result (random effects model) for sensitivity was 81% (95% CI 77–85) and for specificity was 88% (95% CI 85–90). The area under the weighted symmetric summary receiver operating curve was 0.9186. In the endoscope‐based CLE subgroup, the sensitivity was 82% (95% CI 69–91) and specificity was 94% (95% CI 91–96). In the probe‐based CLE subgroup, the sensitivity was 81% (95% CI 76–85) and the specificity was 75% (95% CI 69–81).
Conclusion
CLE, using either the endoscope‐based CLE or probe‐based CLE technique, has high sensitivity and specificity. It could therefore be considered as an alternative endoscopic method to distinguish neoplastic from non‐neoplastic lesions.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenoma - diagnosis</subject><subject>Adenoma - pathology</subject><subject>Colonoscopy - methods</subject><subject>colorectal neoplasia</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - pathology</subject><subject>confocal endomicroscopy</subject><subject>Confocal laser endomicroscopy</subject><subject>Early Detection of Cancer - methods</subject><subject>endoscopy</subject><subject>Humans</subject><subject>meta-analysis</subject><subject>Microscopy, Confocal - methods</subject><subject>Sensitivity and Specificity</subject><issn>1462-8910</issn><issn>1463-1318</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOAyEUhonRaL1sfAAzS2MyyqUDzNLUe2q7qZe4IQhnIjodKkyjfXtpR7uUDZB8359zfoQOCT4l6ZwZb90poYyWG6hH-pzlhBG5uXrTXJYE76DdGN8xJlwQuY12KJMEE1z00PM9tDrXja4X0cXMV5nxTeWNrrNaRwgZNNZPnQk-Gj9bZJUPWfsGmYUWTOt80ym1D-mbpAb8LIlO76OtStcRDn7vPfRwdTkZ3OTD8fXt4HyYG8ZFmXMDsiq4KaR-FbRfirLUkhTWAuemEhprxqROY1NjqcEAwvLK2oJrAJmWYHvouMudBf85h9iqqYsG6lqnUeZRkT6ThaCMLdGTDl1uEwNUahbcVIeFIlgtm1TLJtWqyQQf_ebOX6dg1-hfdQkgHfDlalj8E6UG44vbv9C8c1xs4Xvt6PChuGCiUE-ja_XSf5zQOzZSQ_YDdqaOcg</recordid><startdate>201309</startdate><enddate>201309</enddate><creator>Dong, Y.-Y.</creator><creator>Li, Y.-Q.</creator><creator>Yu, Y.-B.</creator><creator>Liu, J.</creator><creator>Li, M.</creator><creator>Luan, X.-R.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201309</creationdate><title>Meta-analysis of confocal laser endomicroscopy for the detection of colorectal neoplasia</title><author>Dong, Y.-Y. ; Li, Y.-Q. ; Yu, Y.-B. ; Liu, J. ; Li, M. ; Luan, X.-R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3679-6ce8f56c58ab7249799a815dde66cf7a0a338a6712cd2c0ee7d6fdd56aee88103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenoma - diagnosis</topic><topic>Adenoma - pathology</topic><topic>Colonoscopy - methods</topic><topic>colorectal neoplasia</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - pathology</topic><topic>confocal endomicroscopy</topic><topic>Confocal laser endomicroscopy</topic><topic>Early Detection of Cancer - methods</topic><topic>endoscopy</topic><topic>Humans</topic><topic>meta-analysis</topic><topic>Microscopy, Confocal - methods</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dong, Y.-Y.</creatorcontrib><creatorcontrib>Li, Y.-Q.</creatorcontrib><creatorcontrib>Yu, Y.-B.</creatorcontrib><creatorcontrib>Liu, J.</creatorcontrib><creatorcontrib>Li, M.</creatorcontrib><creatorcontrib>Luan, X.-R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Y.-Y.</au><au>Li, Y.-Q.</au><au>Yu, Y.-B.</au><au>Liu, J.</au><au>Li, M.</au><au>Luan, X.-R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meta-analysis of confocal laser endomicroscopy for the detection of colorectal neoplasia</atitle><jtitle>Colorectal disease</jtitle><addtitle>Colorectal Dis</addtitle><date>2013-09</date><risdate>2013</risdate><volume>15</volume><issue>9</issue><spage>e488</spage><epage>e495</epage><pages>e488-e495</pages><issn>1462-8910</issn><eissn>1463-1318</eissn><abstract>Aim
Confocal laser endomicroscopy (CLE) is a recently developed technique used to image colorectal neoplasia. Trials have shown varied results when it is compared with conventional colonoscopy. A meta‐analysis was performed to determine the diagnostic accuracy of CLE in the detection of colorectal neoplasia.
Method
A search was performed for studies assessing the accuracy of CLE in colorectal neoplasia. Studies comparing CLE diagnostic accuracy with conventional endoscopy in the detection of colorectal neoplasia were included. Exclusion criteria included case reports or case series, reviews, duplicate reports or insufficient data in the paper. Seventy‐eight titles came up in the initial search and six studies were selected. These were subjected to a meta‐analysis. In all, 284 patients with 1030 lesions were included. Each patient underwent conventional colonoscopy and CLE. Per‐lesion sensitivity and specificity with 95% CI were calculated.
Results
In the individual studies, the sensitivity ranged from 33.3% to 100% and specificity from 71.6% to 99.4%. The weighted and total pooled result (random effects model) for sensitivity was 81% (95% CI 77–85) and for specificity was 88% (95% CI 85–90). The area under the weighted symmetric summary receiver operating curve was 0.9186. In the endoscope‐based CLE subgroup, the sensitivity was 82% (95% CI 69–91) and specificity was 94% (95% CI 91–96). In the probe‐based CLE subgroup, the sensitivity was 81% (95% CI 76–85) and the specificity was 75% (95% CI 69–81).
Conclusion
CLE, using either the endoscope‐based CLE or probe‐based CLE technique, has high sensitivity and specificity. It could therefore be considered as an alternative endoscopic method to distinguish neoplastic from non‐neoplastic lesions.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23810105</pmid><doi>10.1111/codi.12329</doi><tpages>8</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1462-8910 |
ispartof | Colorectal disease, 2013-09, Vol.15 (9), p.e488-e495 |
issn | 1462-8910 1463-1318 |
language | eng |
recordid | cdi_proquest_miscellaneous_1438572330 |
source | MEDLINE; Access via Wiley Online Library |
subjects | Adenocarcinoma - diagnosis Adenocarcinoma - pathology Adenoma - diagnosis Adenoma - pathology Colonoscopy - methods colorectal neoplasia Colorectal Neoplasms - diagnosis Colorectal Neoplasms - pathology confocal endomicroscopy Confocal laser endomicroscopy Early Detection of Cancer - methods endoscopy Humans meta-analysis Microscopy, Confocal - methods Sensitivity and Specificity |
title | Meta-analysis of confocal laser endomicroscopy for the detection of colorectal neoplasia |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T05%3A45%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Meta-analysis%20of%20confocal%20laser%20endomicroscopy%20for%20the%20detection%20of%20colorectal%20neoplasia&rft.jtitle=Colorectal%20disease&rft.au=Dong,%20Y.-Y.&rft.date=2013-09&rft.volume=15&rft.issue=9&rft.spage=e488&rft.epage=e495&rft.pages=e488-e495&rft.issn=1462-8910&rft.eissn=1463-1318&rft_id=info:doi/10.1111/codi.12329&rft_dat=%3Cproquest_cross%3E1438572330%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1438572330&rft_id=info:pmid/23810105&rfr_iscdi=true |