Metabolic syndrome in normoglycaemic elderly men
Summary Objective Type‐2 diabetes is mainly the metabolic defect involving multiple organs. To conclude their intricate relationships, the term ‘ominous octet’ had been proposed to denote this phenomenon. In this study, we enrolled older men without any medications for MetS components to further elu...
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| Veröffentlicht in: | International journal of clinical practice (Esher) 2013-10, Vol.67 (10), p.964-970 |
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| container_title | International journal of clinical practice (Esher) |
| container_volume | 67 |
| creator | Lian, W.-C. Lin, J.-D. Hsia, T.-L. Hsu, C.-H. Wu, C.-Z. Hsieh, C.-H. Pei, D. Chen, Y.-L. |
| description | Summary
Objective
Type‐2 diabetes is mainly the metabolic defect involving multiple organs. To conclude their intricate relationships, the term ‘ominous octet’ had been proposed to denote this phenomenon. In this study, we enrolled older men without any medications for MetS components to further elucidate the relationships between normoglycaemic state and MetS.
Methods
We enrolled male subjects with FPG less than 100 mg/dl and aged 65 and older undergoing routine health check‐ups in Taiwan. After excluding subjects taking medications that might affect the components of MetS, a total of 6679 men were eligible for the analysis. Study subjects were further grouped into FPG tertiles ( 95 mg/dl for tertil 1, tertil 2 and tertil 3, respectively).
Results
There was a significant trend between the FPG and percentages of subjects having MetS (p = 0.009). The relationships between the MetS components were higher in FPG 2 and FPG 3 than FPG 1. In simple correlation, all of the MetS and LDL‐C were positively correlated with FPG level and multiple regression further confirmed the same result except for HDL‐C that became non‐significant. Subjects in FPG3 had significantly higher ORs (ORs = 1.19) for having MetS than those in FPG1.
Conclusions
In conclusion, higher FPG still had higher risk of having MetS in normoglycaemic range in elderly male. More strict FPG level control may be valuable in CVD prevention and warrants further investigations. |
| doi_str_mv | 10.1111/ijcp.12166 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1438572113</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1438572113</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3956-783eeb0576cbd20262cc21ab7be28ab7942115c338c0d933d407ad936680dbd63</originalsourceid><addsrcrecordid>eNp9kE1Lw0AQhhdRrFYv_gAJeBEhdT-S3eQoRWtLq5Yqgpcl2UwldZPU3QbNv3dr2h48OJcZmGcehhehM4J7xNV1vlDLHqGE8z10RERAfUIDsu9mxiM_xIx00LG1C4xpGEb4EHVogAWLBT1CeAKrJK10rjzblJmpCvDy0isrU1TvulEJFG4FOgOjG6-A8gQdzBNt4XTTu-jl7va5f--PHwfD_s3YVywOuS8iBpDiUHCVZhRTTpWiJElFCjRyLQ4oIaFiLFI4ixnL3EeJGziPcJZmnHXRZetdmuqzBruSRW4VaJ2UUNVWkoBFoXAS5tCLP-iiqk3pvltTjokZEY66aillKmsNzOXS5EViGkmwXOco1znK3xwdfL5R1mkB2Q7dBucA0gJfuYbmH5UcjvpPW6nf3uR2Bd-7m8R8SC6YCOXrw0DO3maT6VSM5IT9ADAhink</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1437219317</pqid></control><display><type>article</type><title>Metabolic syndrome in normoglycaemic elderly men</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lian, W.-C. ; Lin, J.-D. ; Hsia, T.-L. ; Hsu, C.-H. ; Wu, C.-Z. ; Hsieh, C.-H. ; Pei, D. ; Chen, Y.-L.</creator><creatorcontrib>Lian, W.-C. ; Lin, J.-D. ; Hsia, T.-L. ; Hsu, C.-H. ; Wu, C.-Z. ; Hsieh, C.-H. ; Pei, D. ; Chen, Y.-L.</creatorcontrib><description>Summary
Objective
Type‐2 diabetes is mainly the metabolic defect involving multiple organs. To conclude their intricate relationships, the term ‘ominous octet’ had been proposed to denote this phenomenon. In this study, we enrolled older men without any medications for MetS components to further elucidate the relationships between normoglycaemic state and MetS.
Methods
We enrolled male subjects with FPG less than 100 mg/dl and aged 65 and older undergoing routine health check‐ups in Taiwan. After excluding subjects taking medications that might affect the components of MetS, a total of 6679 men were eligible for the analysis. Study subjects were further grouped into FPG tertiles (< 91 mg/dl, 92–95 mg/dl and > 95 mg/dl for tertil 1, tertil 2 and tertil 3, respectively).
Results
There was a significant trend between the FPG and percentages of subjects having MetS (p = 0.009). The relationships between the MetS components were higher in FPG 2 and FPG 3 than FPG 1. In simple correlation, all of the MetS and LDL‐C were positively correlated with FPG level and multiple regression further confirmed the same result except for HDL‐C that became non‐significant. Subjects in FPG3 had significantly higher ORs (ORs = 1.19) for having MetS than those in FPG1.
Conclusions
In conclusion, higher FPG still had higher risk of having MetS in normoglycaemic range in elderly male. More strict FPG level control may be valuable in CVD prevention and warrants further investigations.</description><identifier>ISSN: 1368-5031</identifier><identifier>EISSN: 1742-1241</identifier><identifier>DOI: 10.1111/ijcp.12166</identifier><identifier>PMID: 24073972</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Aged ; Analysis of Variance ; Blood Glucose - metabolism ; Clinical medicine ; Clinical trials ; Cross-Sectional Studies ; Diabetes ; Fasting - blood ; Humans ; Hyperglycemia - blood ; Hyperglycemia - complications ; Male ; Mens health ; Metabolic syndrome ; Metabolic Syndrome - blood ; Metabolic Syndrome - etiology ; Older people</subject><ispartof>International journal of clinical practice (Esher), 2013-10, Vol.67 (10), p.964-970</ispartof><rights>2013 John Wiley & Sons Ltd</rights><rights>2013 John Wiley & Sons Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3956-783eeb0576cbd20262cc21ab7be28ab7942115c338c0d933d407ad936680dbd63</citedby><cites>FETCH-LOGICAL-c3956-783eeb0576cbd20262cc21ab7be28ab7942115c338c0d933d407ad936680dbd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijcp.12166$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijcp.12166$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24073972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lian, W.-C.</creatorcontrib><creatorcontrib>Lin, J.-D.</creatorcontrib><creatorcontrib>Hsia, T.-L.</creatorcontrib><creatorcontrib>Hsu, C.-H.</creatorcontrib><creatorcontrib>Wu, C.-Z.</creatorcontrib><creatorcontrib>Hsieh, C.-H.</creatorcontrib><creatorcontrib>Pei, D.</creatorcontrib><creatorcontrib>Chen, Y.-L.</creatorcontrib><title>Metabolic syndrome in normoglycaemic elderly men</title><title>International journal of clinical practice (Esher)</title><addtitle>Int J Clin Pract</addtitle><description>Summary
Objective
Type‐2 diabetes is mainly the metabolic defect involving multiple organs. To conclude their intricate relationships, the term ‘ominous octet’ had been proposed to denote this phenomenon. In this study, we enrolled older men without any medications for MetS components to further elucidate the relationships between normoglycaemic state and MetS.
Methods
We enrolled male subjects with FPG less than 100 mg/dl and aged 65 and older undergoing routine health check‐ups in Taiwan. After excluding subjects taking medications that might affect the components of MetS, a total of 6679 men were eligible for the analysis. Study subjects were further grouped into FPG tertiles (< 91 mg/dl, 92–95 mg/dl and > 95 mg/dl for tertil 1, tertil 2 and tertil 3, respectively).
Results
There was a significant trend between the FPG and percentages of subjects having MetS (p = 0.009). The relationships between the MetS components were higher in FPG 2 and FPG 3 than FPG 1. In simple correlation, all of the MetS and LDL‐C were positively correlated with FPG level and multiple regression further confirmed the same result except for HDL‐C that became non‐significant. Subjects in FPG3 had significantly higher ORs (ORs = 1.19) for having MetS than those in FPG1.
Conclusions
In conclusion, higher FPG still had higher risk of having MetS in normoglycaemic range in elderly male. More strict FPG level control may be valuable in CVD prevention and warrants further investigations.</description><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Blood Glucose - metabolism</subject><subject>Clinical medicine</subject><subject>Clinical trials</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Fasting - blood</subject><subject>Humans</subject><subject>Hyperglycemia - blood</subject><subject>Hyperglycemia - complications</subject><subject>Male</subject><subject>Mens health</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - etiology</subject><subject>Older people</subject><issn>1368-5031</issn><issn>1742-1241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRrFYv_gAJeBEhdT-S3eQoRWtLq5Yqgpcl2UwldZPU3QbNv3dr2h48OJcZmGcehhehM4J7xNV1vlDLHqGE8z10RERAfUIDsu9mxiM_xIx00LG1C4xpGEb4EHVogAWLBT1CeAKrJK10rjzblJmpCvDy0isrU1TvulEJFG4FOgOjG6-A8gQdzBNt4XTTu-jl7va5f--PHwfD_s3YVywOuS8iBpDiUHCVZhRTTpWiJElFCjRyLQ4oIaFiLFI4ixnL3EeJGziPcJZmnHXRZetdmuqzBruSRW4VaJ2UUNVWkoBFoXAS5tCLP-iiqk3pvltTjokZEY66aillKmsNzOXS5EViGkmwXOco1znK3xwdfL5R1mkB2Q7dBucA0gJfuYbmH5UcjvpPW6nf3uR2Bd-7m8R8SC6YCOXrw0DO3maT6VSM5IT9ADAhink</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Lian, W.-C.</creator><creator>Lin, J.-D.</creator><creator>Hsia, T.-L.</creator><creator>Hsu, C.-H.</creator><creator>Wu, C.-Z.</creator><creator>Hsieh, C.-H.</creator><creator>Pei, D.</creator><creator>Chen, Y.-L.</creator><general>Blackwell Publishing Ltd</general><general>Hindawi Limited</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201310</creationdate><title>Metabolic syndrome in normoglycaemic elderly men</title><author>Lian, W.-C. ; Lin, J.-D. ; Hsia, T.-L. ; Hsu, C.-H. ; Wu, C.-Z. ; Hsieh, C.-H. ; Pei, D. ; Chen, Y.-L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3956-783eeb0576cbd20262cc21ab7be28ab7942115c338c0d933d407ad936680dbd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Blood Glucose - metabolism</topic><topic>Clinical medicine</topic><topic>Clinical trials</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Fasting - blood</topic><topic>Humans</topic><topic>Hyperglycemia - blood</topic><topic>Hyperglycemia - complications</topic><topic>Male</topic><topic>Mens health</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - etiology</topic><topic>Older people</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lian, W.-C.</creatorcontrib><creatorcontrib>Lin, J.-D.</creatorcontrib><creatorcontrib>Hsia, T.-L.</creatorcontrib><creatorcontrib>Hsu, C.-H.</creatorcontrib><creatorcontrib>Wu, C.-Z.</creatorcontrib><creatorcontrib>Hsieh, C.-H.</creatorcontrib><creatorcontrib>Pei, D.</creatorcontrib><creatorcontrib>Chen, Y.-L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical practice (Esher)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lian, W.-C.</au><au>Lin, J.-D.</au><au>Hsia, T.-L.</au><au>Hsu, C.-H.</au><au>Wu, C.-Z.</au><au>Hsieh, C.-H.</au><au>Pei, D.</au><au>Chen, Y.-L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic syndrome in normoglycaemic elderly men</atitle><jtitle>International journal of clinical practice (Esher)</jtitle><addtitle>Int J Clin Pract</addtitle><date>2013-10</date><risdate>2013</risdate><volume>67</volume><issue>10</issue><spage>964</spage><epage>970</epage><pages>964-970</pages><issn>1368-5031</issn><eissn>1742-1241</eissn><abstract>Summary
Objective
Type‐2 diabetes is mainly the metabolic defect involving multiple organs. To conclude their intricate relationships, the term ‘ominous octet’ had been proposed to denote this phenomenon. In this study, we enrolled older men without any medications for MetS components to further elucidate the relationships between normoglycaemic state and MetS.
Methods
We enrolled male subjects with FPG less than 100 mg/dl and aged 65 and older undergoing routine health check‐ups in Taiwan. After excluding subjects taking medications that might affect the components of MetS, a total of 6679 men were eligible for the analysis. Study subjects were further grouped into FPG tertiles (< 91 mg/dl, 92–95 mg/dl and > 95 mg/dl for tertil 1, tertil 2 and tertil 3, respectively).
Results
There was a significant trend between the FPG and percentages of subjects having MetS (p = 0.009). The relationships between the MetS components were higher in FPG 2 and FPG 3 than FPG 1. In simple correlation, all of the MetS and LDL‐C were positively correlated with FPG level and multiple regression further confirmed the same result except for HDL‐C that became non‐significant. Subjects in FPG3 had significantly higher ORs (ORs = 1.19) for having MetS than those in FPG1.
Conclusions
In conclusion, higher FPG still had higher risk of having MetS in normoglycaemic range in elderly male. More strict FPG level control may be valuable in CVD prevention and warrants further investigations.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24073972</pmid><doi>10.1111/ijcp.12166</doi><tpages>7</tpages></addata></record> |
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| ispartof | International journal of clinical practice (Esher), 2013-10, Vol.67 (10), p.964-970 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Analysis of Variance Blood Glucose - metabolism Clinical medicine Clinical trials Cross-Sectional Studies Diabetes Fasting - blood Humans Hyperglycemia - blood Hyperglycemia - complications Male Mens health Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - etiology Older people |
| title | Metabolic syndrome in normoglycaemic elderly men |
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