Multiple Mass Analysis Using an Ion Trap Array (ITA) Mass Analyzer
A novel ion trap array (ITA) mass analyzer with six ion trapping and analyzing channels was investigated. It is capable of analyzing multiple samples simultaneously. The ITA was built with several planar electrodes made of stainless steel and 12 identical parallel zirconia ceramic substrates plated...
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| Veröffentlicht in: | Journal of the American Society for Mass Spectrometry 2013-09, Vol.24 (9), p.1420-1427 |
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| container_title | Journal of the American Society for Mass Spectrometry |
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| creator | Xiao, Yu Chu, Yanqiu Ling, Xing Ding, Zhengzhi Xu, Chongsheng Ding, Li Ding, Chuan-Fan |
| description | A novel ion trap array (ITA) mass analyzer with six ion trapping and analyzing channels was investigated. It is capable of analyzing multiple samples simultaneously. The ITA was built with several planar electrodes made of stainless steel and 12 identical parallel zirconia ceramic substrates plated with conductive metal layers. Each two of the opposing ceramic electrode plates formed a boundary of an ion trap channel and six identical ion trapping and analyzing channels were placed in parallel without physical electrode between any two adjacent channels. The electric field distribution inside each channel was studied with simulation. The new design took the advantage of high precision machining attributable to the rigidity of ceramic, and the convenience of surface patterning technique. The ITA system was tested by using a two-channel electrospray ionization source, a multichannel simultaneous quadruple ion guide, and two detectors. The simultaneous analysis of two different samples with two adjacent ITA channels was achieved and independent mass spectra were obtained. For each channel, the mass resolution was tested. Additional ion trap functions such as mass-selected ion isolation and collision-induced dissociation (CID) were also tested. The results show that one ITA is well suited for multiple simultaneous mass analyses. |
| doi_str_mv | 10.1007/s13361-013-0679-9 |
| format | Article |
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It is capable of analyzing multiple samples simultaneously. The ITA was built with several planar electrodes made of stainless steel and 12 identical parallel zirconia ceramic substrates plated with conductive metal layers. Each two of the opposing ceramic electrode plates formed a boundary of an ion trap channel and six identical ion trapping and analyzing channels were placed in parallel without physical electrode between any two adjacent channels. The electric field distribution inside each channel was studied with simulation. The new design took the advantage of high precision machining attributable to the rigidity of ceramic, and the convenience of surface patterning technique. The ITA system was tested by using a two-channel electrospray ionization source, a multichannel simultaneous quadruple ion guide, and two detectors. The simultaneous analysis of two different samples with two adjacent ITA channels was achieved and independent mass spectra were obtained. For each channel, the mass resolution was tested. Additional ion trap functions such as mass-selected ion isolation and collision-induced dissociation (CID) were also tested. The results show that one ITA is well suited for multiple simultaneous mass analyses.</description><identifier>ISSN: 1044-0305</identifier><identifier>EISSN: 1879-1123</identifier><identifier>DOI: 10.1007/s13361-013-0679-9</identifier><identifier>PMID: 23797864</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Analytical Chemistry ; Bioinformatics ; Biotechnology ; Ceramics ; Channels ; Chemistry ; Chemistry and Materials Science ; Collision dynamics ; Electric power distribution ; Electrodes ; Ionization ; Ions ; Machining ; Mass spectra ; Mass spectrometry ; Organic Chemistry ; Precision machining ; Proteomics ; Research Article ; Substrates ; Trapping ; Zirconium dioxide</subject><ispartof>Journal of the American Society for Mass Spectrometry, 2013-09, Vol.24 (9), p.1420-1427</ispartof><rights>American Society for Mass Spectrometry 2013</rights><rights>Journal of The American Society for Mass Spectrometry is a copyright of Springer, 2013.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-e3e6845dc37a5c28b920552e208145f40cced96454ea8b3c53e92909baf62e763</citedby><cites>FETCH-LOGICAL-c372t-e3e6845dc37a5c28b920552e208145f40cced96454ea8b3c53e92909baf62e763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13361-013-0679-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13361-013-0679-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23797864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiao, Yu</creatorcontrib><creatorcontrib>Chu, Yanqiu</creatorcontrib><creatorcontrib>Ling, Xing</creatorcontrib><creatorcontrib>Ding, Zhengzhi</creatorcontrib><creatorcontrib>Xu, Chongsheng</creatorcontrib><creatorcontrib>Ding, Li</creatorcontrib><creatorcontrib>Ding, Chuan-Fan</creatorcontrib><title>Multiple Mass Analysis Using an Ion Trap Array (ITA) Mass Analyzer</title><title>Journal of the American Society for Mass Spectrometry</title><addtitle>J. Am. Soc. Mass Spectrom</addtitle><addtitle>J Am Soc Mass Spectrom</addtitle><description>A novel ion trap array (ITA) mass analyzer with six ion trapping and analyzing channels was investigated. It is capable of analyzing multiple samples simultaneously. The ITA was built with several planar electrodes made of stainless steel and 12 identical parallel zirconia ceramic substrates plated with conductive metal layers. Each two of the opposing ceramic electrode plates formed a boundary of an ion trap channel and six identical ion trapping and analyzing channels were placed in parallel without physical electrode between any two adjacent channels. The electric field distribution inside each channel was studied with simulation. The new design took the advantage of high precision machining attributable to the rigidity of ceramic, and the convenience of surface patterning technique. The ITA system was tested by using a two-channel electrospray ionization source, a multichannel simultaneous quadruple ion guide, and two detectors. The simultaneous analysis of two different samples with two adjacent ITA channels was achieved and independent mass spectra were obtained. For each channel, the mass resolution was tested. Additional ion trap functions such as mass-selected ion isolation and collision-induced dissociation (CID) were also tested. 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Am. Soc. Mass Spectrom</stitle><addtitle>J Am Soc Mass Spectrom</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>24</volume><issue>9</issue><spage>1420</spage><epage>1427</epage><pages>1420-1427</pages><issn>1044-0305</issn><eissn>1879-1123</eissn><abstract>A novel ion trap array (ITA) mass analyzer with six ion trapping and analyzing channels was investigated. It is capable of analyzing multiple samples simultaneously. The ITA was built with several planar electrodes made of stainless steel and 12 identical parallel zirconia ceramic substrates plated with conductive metal layers. Each two of the opposing ceramic electrode plates formed a boundary of an ion trap channel and six identical ion trapping and analyzing channels were placed in parallel without physical electrode between any two adjacent channels. The electric field distribution inside each channel was studied with simulation. The new design took the advantage of high precision machining attributable to the rigidity of ceramic, and the convenience of surface patterning technique. The ITA system was tested by using a two-channel electrospray ionization source, a multichannel simultaneous quadruple ion guide, and two detectors. The simultaneous analysis of two different samples with two adjacent ITA channels was achieved and independent mass spectra were obtained. For each channel, the mass resolution was tested. Additional ion trap functions such as mass-selected ion isolation and collision-induced dissociation (CID) were also tested. The results show that one ITA is well suited for multiple simultaneous mass analyses.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23797864</pmid><doi>10.1007/s13361-013-0679-9</doi><tpages>8</tpages></addata></record> |
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| subjects | Analytical Chemistry Bioinformatics Biotechnology Ceramics Channels Chemistry Chemistry and Materials Science Collision dynamics Electric power distribution Electrodes Ionization Ions Machining Mass spectra Mass spectrometry Organic Chemistry Precision machining Proteomics Research Article Substrates Trapping Zirconium dioxide |
| title | Multiple Mass Analysis Using an Ion Trap Array (ITA) Mass Analyzer |
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