Carcinogenesis by nonmutagenic chemicals: early response of rat liver cells induced by methapyrilene

Although methapyrilene (MP) produces hepatocellular carcinomas in rats, it does not elicit many of the cellular responses induced by other hepatocarcinogens. We have investigated the early changes induced in rat liver epithelial cell cultures by MP using morphological, cytochemical, and cytofluorome...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1985-05, Vol.45 (5), p.2184-2191
Hauptverfasser:	IYPE, P. T, BUCANA, C. D, KELLEY, S. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyridines - toxicity Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Inclusion Bodies - ultrastructure Lipids - analysis Liver - drug effects Liver - ultrastructure Liver Neoplasms, Experimental - chemically induced Medical sciences Methapyrilene - toxicity Mitochondria, Liver - drug effects Rats Rats, Inbred F344 Tumors
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