The formation of radiation-induced dna breaks: The ratio of double-strand breaks to single-strand breaks
Ionizing radiation causes the formation of strand breaks in cellular DNA, as well as other types of lesions in the chromatin of cells. Some of the earliest investigations of the molecular basis of radiation-induced damage and the implications of enzymatic repair were done by Dr. H. S. Kaplan. The in...
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| Veröffentlicht in: | Int. J. Radiat. Oncol., Biol. Phys.; (United States) Biol. Phys.; (United States), 1985-02, Vol.11 (2), p.259-265 |
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| description | Ionizing radiation causes the formation of strand breaks in cellular DNA, as well as other types of lesions in the chromatin of cells. Some of the earliest investigations of the molecular basis of radiation-induced damage and the implications of enzymatic repair were done by Dr. H. S. Kaplan. The induction frequency of DNA double-strand breaks is of special importance, and it is of interest to know the relative proportions of single-strand and double-strand breaks. This ratio changes noticeably with the radiation quality (ionization density). Because it is difficult to assay for DNA lesions in the large mammalian genome, we have developed a method of assaying for DNA double-strand breaks in the supercoiled nucleosome-complexed Simian virus 40 (SV40) genome, irradiated intracellularly. In this communication we present our measurements of the DNA double-strand breaks (DSBs) to single-strand breaks (SSBs) ratio obtained from the intracellularly irradiated SV40 genome. After cobalt gamma ray and X ray irradiations, this ratio is about
1
10
. Our methods and results are compared with pertinent data in the literature. If the DSBs/SSBs ratio of
1
10
for cellular chromatin is correct, a substantial number of DNA double-strand breaks are formed in a mammalian cell after moderate doses (1 Gy) of radiation. The implications of different types of DNA double-strand breaks are discussed. |
| doi_str_mv | 10.1016/0360-3016(85)90147-6 |
| format | Article |
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1
10
. Our methods and results are compared with pertinent data in the literature. If the DSBs/SSBs ratio of
1
10
for cellular chromatin is correct, a substantial number of DNA double-strand breaks are formed in a mammalian cell after moderate doses (1 Gy) of radiation. The implications of different types of DNA double-strand breaks are discussed.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/0360-3016(85)90147-6</identifier><identifier>PMID: 2982769</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>560111 - Radiation Effects on Biochemicals- In Vitro- (-1987) ; ANIMAL CELLS ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; COBALT 60 ; COBALT ISOTOPES ; Cobalt Radioisotopes ; DNA ; DNA - radiation effects ; DNA double-strand breaks ; DNA, Single-Stranded - radiation effects ; DNA, Viral - radiation effects ; Dose-Response Relationship, Radiation ; ELECTROMAGNETIC RADIATION ; ELECTROPHORESIS ; FLUORESCENCE ; Fundamental and applied biological sciences. Psychology ; GAMMA RADIATION ; Gamma Rays ; Genes, Viral - radiation effects ; INTERMEDIATE MASS NUCLEI ; INTERNAL CONVERSION RADIOISOTOPES ; IONIZING RADIATIONS ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; LUMINESCENCE ; MICROORGANISMS ; MINUTES LIVING RADIOISOTOPES ; Molecular and cellular biology ; MOLECULAR BIOLOGY ; Molecular genetics ; Mutagenesis. Repair ; NUCLEI ; NUCLEIC ACIDS ; ODD-ODD NUCLEI ; ORGANIC COMPOUNDS ; PARASITES ; RADIATION EFFECTS ; RADIATION QUALITY ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; Radiation-induced damage ; RADIATIONS ; RADIOINDUCTION ; RADIOISOTOPES ; SIMIAN VIRUS ; Simian virus 40 ; Simian virus 40 - genetics ; STRAND BREAKS ; VIRUSES ; X RADIATION ; X-Rays ; YEARS LIVING RADIOISOTOPES</subject><ispartof>Int. J. Radiat. Oncol., Biol. Phys.; (United States), 1985-02, Vol.11 (2), p.259-265</ispartof><rights>1985</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-3f1f731b1f808b9ebd6734b7a4f4f5cf954043cf835fe4161f03c3598a1177f73</citedby><cites>FETCH-LOGICAL-c510t-3f1f731b1f808b9ebd6734b7a4f4f5cf954043cf835fe4161f03c3598a1177f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0360301685901476$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,881,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9171760$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2982769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5520675$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Roots, R</creatorcontrib><creatorcontrib>Kraft, G</creatorcontrib><creatorcontrib>Gosschalk, E</creatorcontrib><creatorcontrib>Lawrence Berkeley Lab., CA</creatorcontrib><title>The formation of radiation-induced dna breaks: The ratio of double-strand breaks to single-strand breaks</title><title>Int. J. Radiat. Oncol., Biol. Phys.; (United States)</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Ionizing radiation causes the formation of strand breaks in cellular DNA, as well as other types of lesions in the chromatin of cells. Some of the earliest investigations of the molecular basis of radiation-induced damage and the implications of enzymatic repair were done by Dr. H. S. Kaplan. The induction frequency of DNA double-strand breaks is of special importance, and it is of interest to know the relative proportions of single-strand and double-strand breaks. This ratio changes noticeably with the radiation quality (ionization density). Because it is difficult to assay for DNA lesions in the large mammalian genome, we have developed a method of assaying for DNA double-strand breaks in the supercoiled nucleosome-complexed Simian virus 40 (SV40) genome, irradiated intracellularly. In this communication we present our measurements of the DNA double-strand breaks (DSBs) to single-strand breaks (SSBs) ratio obtained from the intracellularly irradiated SV40 genome. After cobalt gamma ray and X ray irradiations, this ratio is about
1
10
. Our methods and results are compared with pertinent data in the literature. If the DSBs/SSBs ratio of
1
10
for cellular chromatin is correct, a substantial number of DNA double-strand breaks are formed in a mammalian cell after moderate doses (1 Gy) of radiation. The implications of different types of DNA double-strand breaks are discussed.</description><subject>560111 - Radiation Effects on Biochemicals- In Vitro- (-1987)</subject><subject>ANIMAL CELLS</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>COBALT 60</subject><subject>COBALT ISOTOPES</subject><subject>Cobalt Radioisotopes</subject><subject>DNA</subject><subject>DNA - radiation effects</subject><subject>DNA double-strand breaks</subject><subject>DNA, Single-Stranded - radiation effects</subject><subject>DNA, Viral - radiation effects</subject><subject>Dose-Response Relationship, Radiation</subject><subject>ELECTROMAGNETIC RADIATION</subject><subject>ELECTROPHORESIS</subject><subject>FLUORESCENCE</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GAMMA RADIATION</subject><subject>Gamma Rays</subject><subject>Genes, Viral - radiation effects</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>INTERNAL CONVERSION RADIOISOTOPES</subject><subject>IONIZING RADIATIONS</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>LUMINESCENCE</subject><subject>MICROORGANISMS</subject><subject>MINUTES LIVING RADIOISOTOPES</subject><subject>Molecular and cellular biology</subject><subject>MOLECULAR BIOLOGY</subject><subject>Molecular genetics</subject><subject>Mutagenesis. Repair</subject><subject>NUCLEI</subject><subject>NUCLEIC ACIDS</subject><subject>ODD-ODD NUCLEI</subject><subject>ORGANIC COMPOUNDS</subject><subject>PARASITES</subject><subject>RADIATION EFFECTS</subject><subject>RADIATION QUALITY</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>Radiation-induced damage</subject><subject>RADIATIONS</subject><subject>RADIOINDUCTION</subject><subject>RADIOISOTOPES</subject><subject>SIMIAN VIRUS</subject><subject>Simian virus 40</subject><subject>Simian virus 40 - genetics</subject><subject>STRAND BREAKS</subject><subject>VIRUSES</subject><subject>X RADIATION</subject><subject>X-Rays</subject><subject>YEARS LIVING RADIOISOTOPES</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctrFTEUxoMo7e3jP1AYREQXU3NunuNCkFJtoeCmQnchk4c37dykJjOF_vdmeoe76MJVHuf3Hc75PoTeAj4DDPwLJhy3pN4-Sfa5w0BFy1-hFUjRtYSx29dotUcO0VEpdxhjAEEP0MG6k2vBuxXa3Gxc41Pe6jGk2CTfZG3D86MN0U7G2cZG3fTZ6fvytZnxPJdn1KapH1xbxqyjXZBmTE0J8c_L_xP0xuuhuNPlPEa_f1zcnF-2179-Xp1_v24NAzy2xIMXBHrwEsu-c73lgtBeaOqpZ8Z3jGJKjJeEeUeBg8fEENZJXTcTVXqM3u_6pjIGVUwYndmYFKMzo2JsjblgFfq4gx5y-ju5MqptKMYNg44uTUUBJRJzIBWkO9DkVEp2Xj3ksNX5SQFWcwpqtljNFivJ1HMKilfZu6X_1G-d3YsW22v9w1LXxejBV59MKHusAwGC44p922GuGvYYXJ73cbFmEvK8jk3h_3P8A5zhoow</recordid><startdate>198502</startdate><enddate>198502</enddate><creator>Roots, R</creator><creator>Kraft, G</creator><creator>Gosschalk, E</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7U7</scope><scope>C1K</scope><scope>OTOTI</scope></search><sort><creationdate>198502</creationdate><title>The formation of radiation-induced dna breaks: The ratio of double-strand breaks to single-strand breaks</title><author>Roots, R ; Kraft, G ; Gosschalk, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-3f1f731b1f808b9ebd6734b7a4f4f5cf954043cf835fe4161f03c3598a1177f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>560111 - Radiation Effects on Biochemicals- In Vitro- (-1987)</topic><topic>ANIMAL CELLS</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>COBALT 60</topic><topic>COBALT ISOTOPES</topic><topic>Cobalt Radioisotopes</topic><topic>DNA</topic><topic>DNA - radiation effects</topic><topic>DNA double-strand breaks</topic><topic>DNA, Single-Stranded - radiation effects</topic><topic>DNA, Viral - radiation effects</topic><topic>Dose-Response Relationship, Radiation</topic><topic>ELECTROMAGNETIC RADIATION</topic><topic>ELECTROPHORESIS</topic><topic>FLUORESCENCE</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GAMMA RADIATION</topic><topic>Gamma Rays</topic><topic>Genes, Viral - radiation effects</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>INTERNAL CONVERSION RADIOISOTOPES</topic><topic>IONIZING RADIATIONS</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPES</topic><topic>LUMINESCENCE</topic><topic>MICROORGANISMS</topic><topic>MINUTES LIVING RADIOISOTOPES</topic><topic>Molecular and cellular biology</topic><topic>MOLECULAR BIOLOGY</topic><topic>Molecular genetics</topic><topic>Mutagenesis. Repair</topic><topic>NUCLEI</topic><topic>NUCLEIC ACIDS</topic><topic>ODD-ODD NUCLEI</topic><topic>ORGANIC COMPOUNDS</topic><topic>PARASITES</topic><topic>RADIATION EFFECTS</topic><topic>RADIATION QUALITY</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>Radiation-induced damage</topic><topic>RADIATIONS</topic><topic>RADIOINDUCTION</topic><topic>RADIOISOTOPES</topic><topic>SIMIAN VIRUS</topic><topic>Simian virus 40</topic><topic>Simian virus 40 - genetics</topic><topic>STRAND BREAKS</topic><topic>VIRUSES</topic><topic>X RADIATION</topic><topic>X-Rays</topic><topic>YEARS LIVING RADIOISOTOPES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roots, R</creatorcontrib><creatorcontrib>Kraft, G</creatorcontrib><creatorcontrib>Gosschalk, E</creatorcontrib><creatorcontrib>Lawrence Berkeley Lab., CA</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>OSTI.GOV</collection><jtitle>Int. J. Radiat. Oncol., Biol. Phys.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roots, R</au><au>Kraft, G</au><au>Gosschalk, E</au><aucorp>Lawrence Berkeley Lab., CA</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The formation of radiation-induced dna breaks: The ratio of double-strand breaks to single-strand breaks</atitle><jtitle>Int. J. Radiat. Oncol., Biol. Phys.; (United States)</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>1985-02</date><risdate>1985</risdate><volume>11</volume><issue>2</issue><spage>259</spage><epage>265</epage><pages>259-265</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>Ionizing radiation causes the formation of strand breaks in cellular DNA, as well as other types of lesions in the chromatin of cells. Some of the earliest investigations of the molecular basis of radiation-induced damage and the implications of enzymatic repair were done by Dr. H. S. Kaplan. The induction frequency of DNA double-strand breaks is of special importance, and it is of interest to know the relative proportions of single-strand and double-strand breaks. This ratio changes noticeably with the radiation quality (ionization density). Because it is difficult to assay for DNA lesions in the large mammalian genome, we have developed a method of assaying for DNA double-strand breaks in the supercoiled nucleosome-complexed Simian virus 40 (SV40) genome, irradiated intracellularly. In this communication we present our measurements of the DNA double-strand breaks (DSBs) to single-strand breaks (SSBs) ratio obtained from the intracellularly irradiated SV40 genome. After cobalt gamma ray and X ray irradiations, this ratio is about
1
10
. Our methods and results are compared with pertinent data in the literature. If the DSBs/SSBs ratio of
1
10
for cellular chromatin is correct, a substantial number of DNA double-strand breaks are formed in a mammalian cell after moderate doses (1 Gy) of radiation. The implications of different types of DNA double-strand breaks are discussed.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2982769</pmid><doi>10.1016/0360-3016(85)90147-6</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Int. J. Radiat. Oncol., Biol. Phys.; (United States), 1985-02, Vol.11 (2), p.259-265 |
| issn | 0360-3016 1879-355X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14380613 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 560111 - Radiation Effects on Biochemicals- In Vitro- (-1987) ANIMAL CELLS BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS COBALT 60 COBALT ISOTOPES Cobalt Radioisotopes DNA DNA - radiation effects DNA double-strand breaks DNA, Single-Stranded - radiation effects DNA, Viral - radiation effects Dose-Response Relationship, Radiation ELECTROMAGNETIC RADIATION ELECTROPHORESIS FLUORESCENCE Fundamental and applied biological sciences. Psychology GAMMA RADIATION Gamma Rays Genes, Viral - radiation effects INTERMEDIATE MASS NUCLEI INTERNAL CONVERSION RADIOISOTOPES IONIZING RADIATIONS ISOMERIC TRANSITION ISOTOPES ISOTOPES LUMINESCENCE MICROORGANISMS MINUTES LIVING RADIOISOTOPES Molecular and cellular biology MOLECULAR BIOLOGY Molecular genetics Mutagenesis. Repair NUCLEI NUCLEIC ACIDS ODD-ODD NUCLEI ORGANIC COMPOUNDS PARASITES RADIATION EFFECTS RADIATION QUALITY RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Radiation-induced damage RADIATIONS RADIOINDUCTION RADIOISOTOPES SIMIAN VIRUS Simian virus 40 Simian virus 40 - genetics STRAND BREAKS VIRUSES X RADIATION X-Rays YEARS LIVING RADIOISOTOPES |
| title | The formation of radiation-induced dna breaks: The ratio of double-strand breaks to single-strand breaks |
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