Epigenetic Modifications in Breast Cancer and Their Role in Personalized Medicine
In cancer, the overall patterns of epigenetic marks are severely distorted from the corresponding normal cell type. It is now well established that these changes can contribute to cancer development through inactivation of tumor suppressor genes and, conversely, through activation of oncogenes. Rece...
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| Veröffentlicht in: | The American journal of pathology 2013-10, Vol.183 (4), p.1052-1063 |
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| container_title | The American journal of pathology |
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| creator | Stefansson, Olafur A Esteller, Manel |
| description | In cancer, the overall patterns of epigenetic marks are severely distorted from the corresponding normal cell type. It is now well established that these changes can contribute to cancer development through inactivation of tumor suppressor genes and, conversely, through activation of oncogenes. Recent technological advances have enabled epigenome-wide analyses of cancers that are yielding unexpected findings. The study of cancer epigenetics holds great promise for expanding the range of therapeutic opportunities for personalized medicine. Here, we focus on DNA methylation in breast cancer and the potential implications for clinical management of patients. |
| doi_str_mv | 10.1016/j.ajpath.2013.04.033 |
| format | Article |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | BRCA1 Protein - genetics Breast Neoplasms - genetics Breast Neoplasms - therapy DNA Methylation - genetics Epigenesis, Genetic Female Humans Mutation - genetics Pathology Precision Medicine |
| title | Epigenetic Modifications in Breast Cancer and Their Role in Personalized Medicine |
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