Cloning, Characterization, and Inhibition Studies of a β‑Carbonic Anhydrase from Leishmania donovani chagasi, the Protozoan Parasite Responsible for Leishmaniasis

Leishmaniasis is an infection provoked by protozoans belonging to the genus Leishmania. Among the many species and subsepecies of such protozoa, Leishmania donovani chagasi causes visceral leishmaniasis. A β-carbonic anhydrase (CA, EC 4.2.1.1) was cloned and characterized from this organism, denomin...

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Veröffentlicht in:	Journal of medicinal chemistry 2013-09, Vol.56 (18), p.7372-7381
Hauptverfasser:	Syrjänen, Leo, Vermelho, Alane Beatriz, de Almeida Rodrigues, Igor, Corte-Real, Suzana, Salonen, Terhi, Pan, Peiwen, Vullo, Daniela, Parkkila, Seppo, Capasso, Clemente, Supuran, Claudiu T
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antiprotozoal Agents - pharmacology Biocatalysis Carbonic Anhydrase Inhibitors - pharmacology Carbonic Anhydrases - chemistry Carbonic Anhydrases - genetics Carbonic Anhydrases - metabolism Cloning, Molecular Leishmania infantum - drug effects Leishmania infantum - enzymology Leishmania infantum - physiology Leishmaniasis - parasitology Molecular Sequence Data
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